The REPROCELL Blog: research, reports and resources

Why mRNA Reprogramming Is the Key to Safer and Faster iPSC Generation?

10 June 2025

Discover how mRNA reprogramming enhances the safety, efficiency, and scalability of iPSC generation for therapeutic applications. Explore REPROCELL's innovative technologies and services.

New Therapeutic Targets: The Role of IL17-Related Genes in Precision Medicine

09 June 2025

Discover how IL-17 related genes could revolutionize psoriasis treatment, offering new therapeutic targets and paving the way for precision medicine advancements.

Balancing Efficacy and Cognitive Health In Bladder Assays

23 May 2025

New approaches in OAB treatment focus on balancing efficacy and cognitive health, using alternatives to anticholinergics and personalized medicine to improve patient outcomes.

Breaking Barriers in Women’s Health: The World’s First Live Birth Using Fertilo

21 May 2025

Discover how Gameto achieved the world’s first live birth using Fertilo, a revolutionary in vitro oocyte maturation technology. Learn about its stem cell-driven innovation and how it's transforming fertility care for women worldwide.

Key Strategies Central Labs Use to Fast-Track Time to Market

21 May 2025

Learn how central labs use automation, outsourcing, and AI to accelerate drug development, reduce costs, and improve clinical trial accuracy and efficiency.

Key Challenges in Clinical iPSC Applications: How REPROCELL Helps You Succeed

12 May 2025

Overcome key challenges in clinical iPSC applications with REPROCELL's ethical sourcing, advanced reprogramming, and tailored solutions for reliable, scalable therapies.

Epigenetic Modifications: Their Role in iPSC Reprogramming and Differentiation

02 May 2025

Explore the critical role of epigenetic mechanisms like DNA methylation and histone modifications in iPSC reprogramming and differentiation. Learn how optimizing epigenetic stability enhances reprogramming efficiency, reduces variability, and ensures safer, more reliable iPSC applications for research and therapy.

REPROCELL Connects with Maryland Governor Moore During His Japan Visit

22 April 2025

Maryland Governor Moore strengthens biotech ties with Japan, highlighting REPROCELL's pivotal role in the Maryland-Kanagawa partnership during his trade mission.

Exosomes from Stem Cells: iPSC vs. MSC-Derived Exosomes for Aesthetic and Regenerative Medicine

14 April 2025

Discover how iPSC and MSC-derived exosomes revolutionize skin rejuvenation and anti-aging treatments in aesthetic medicine. Main Point Summary: The blog explores the potential of exosomes derived from induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) for skin rejuvenation and anti-aging treatments in aesthetic medicine, comparing their effectiveness, mechanisms, and applications.

Can Stem Cells Revolutionize Sustainable Food Production?

31 March 2025

Discover how stem cell technology is transforming sustainable food production, offering ethical and scalable alternatives to conventional meat, dairy, and seafood.

Advancing Clinical Research Through Patient Engagement: The Impact of Tissue Biopsy Donation

19 March 2025

Discover how patient engagement and tissue biopsy donation are revolutionizing clinical research, enhancing personalized medicine, and fostering deeper collaboration between researchers and patients.

Qkineʼs Animal-Free Growth Factors and Cytokines are ideal for Stem Cell Culture

07 March 2025

Qkine's growth factors and cytokines are of exceptional bioactivity and purity - essential for maintaining and differentiating stem cell cultures.

Prince George’s County Economic Development Corporation Visits REPROCELL USA

03 March 2025

REPROCELL USA hosts Prince George's County Economic Development Corporation, showcasing their biotech services and highlighting the benefits of operating in PG County.

The Therapeutic Advantage of Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells (iMSCs)

24 February 2025

Discover the clinical benefits and advancements of using induced pluripotent stem cells-derived mesenchymal stem cells (iMSCs) in regenerative medicine and therapeutic applications.

REPROCELL Makes its First Appearance at Japan-Maryland Night

18 February 2025

REPROCELL made its debut at Japan-Maryland Night, fostering connections with political and scientific communities to further its mission and showcase its genomic services.

How Biomarkers Are Shaping the Future of Skin Disease Treatment

04 February 2025

Discover how biomarkers are revolutionizing the treatment of skin diseases by enabling more precise and effective therapies.

Redefining Success in IBD Drug Discovery with Human Tissue Models

11 December 2024

Redefining IBD drug discovery with a dual-pronged approach through human bioengineered and fresh tissue.

Pharma AI is Changing Clinical Trials by Optimizing Patient Selection

27 November 2024

AI is revolutionizing clinical trials by optimizing patient selection, improving trial outcomes, and accelerating the development of new drugs.

REPROCELL's Advanced Skin Tissue Engineering

31 October 2024

Discover REPROCELL's pioneering 3D skin tissue engineering, enhancing drug development and skincare research with accurate and robust human skin models.

Plasma or Serum? – You Decide

17 October 2024

Discover the key differences between plasma and serum, their collection methods, and their impact on clinical and experimental outcomes.

From Fibroblasts to Cancer-Attacking Cells: Insights from Recent Research on Natural Killer Cells Derived from Clinical Grade iPSCs

16 October 2024

Discover the differentiation potential of induced pluripotent stem cells (iPSC) to cytotoxic NK cells, including recent advancements in research and therapy.

The Power of Human Tissue Models in Preclinical Research

03 October 2024

Discover how human tissue models are transforming drug safety assessments and improving outcomes in preclinical research through real-world case studies.

What you should know about the FDA’s Biological License Application Process

19 September 2024

Learn about the FDA's Biological License Application process, including submission requirements, review phases, and expedited pathways for biologics approvals.

High Prevalence of BRCA Mutations in Indian Breast Cancer Patients: Insights from a Diagnostic Lab

09 September 2024

High prevalence of BRCA mutations in Indian breast cancer patients underscores the need for tailored genetic testing and early detection strategies.

Understanding Safety Pharmacology in Human Tissues

26 August 2024

Explore the role of safety pharmacology in drug discovery, and the importance of human tissue studies for predicting and mitigating potential effects.

Breaking Ground in Alzheimer’s Research: A New Path to Drug Discovery and Personalized Medicine

22 August 2024

Breaking new ground in Alzheimer's research, a study by Durham University uncovers potential therapeutic targets using advanced stem cell technology.

Nucleic Acid Extraction in Clinical Research

08 August 2024

REPROCELL is revolutionizing drug discovery in clinical research through nucleic acid extraction.

Embracing Every Career Pathway with #NoWrongPath

06 August 2024

This year, we took part in the social media movement #NoWrongPath. Discover our colleagues inspiring story about how he got to where he is today!

Need To Conduct a Multi-Variable Study? REPROCELL Can Help with That!

18 July 2024

Conducting a multi-variable study on cancer risk and family history? Discover how our biorepository and custom collections can assist in your research.

AI in Drug Discovery: The Role of SHAP in Pharmacology

11 July 2024

Learn how Explainable AI, like SHAP, is transforming drug discovery by providing transparency and clarity in machine learning models.

Custom Oligosynthesis: Tailoring Solutions for Specific Research Needs

27 June 2024

Custom oligosynthesis offers tailored solutions for specific research needs, enhancing genetic research, diagnostics, and therapeutics.

Engineered Pigmented Skin Equivalents Reveal UV Protection Mechanisms

18 June 2024

Discover how engineered pigmented skin equivalents reveal UV protection mechanisms and offer insights into skin health at a molecular level.

Harnessing Functional Genomics to Revolutionize Inflammatory Bowel Disease Treatment

07 June 2024

Discover how functional genomics is transforming IBD treatment with groundbreaking research on ETS2's role in inflammation.

REPROCELL USA Inaugurates New GMP Laboratory

07 June 2024

May 15, 2024: REPROCELL USA inaugurated its new GMP BioManufacturing Lab. The facility enables hiPSC and hMSC generation in a contaminant-free environment.

Harnessing the Power of Mesenchymal Stem Cells

27 May 2024

Discover the groundbreaking potential of Mesenchymal Stem Cells (MSCs) in biomedical research and therapeutic development.

What to consider when selecting a central laboratory services provider

07 May 2024

There are a lot of factors to take into consideration when choosing a central laboratory service. Let's walk through them together.

Leveraging Human Tissue Models with Preclinical and Drug Discovery CRO

05 April 2024

Our Preclinical and Drug Discovery CRO is transforming the landscape of drug development with new technologies and ethically sourced human tissue models.

ec23: A Promising ATRA Alternative for Advancing Stem Cell Research

13 December 2023

Learn how ec23 acts as a improved alternative to ATRA.

Quality Control: What is really in your hiPSC culture?

11 December 2023

Whatever the goals of your project, a robust QC testing protocol assessing sterility, pluripotency, and genetic abnormalities, while maintaining sample identity, is critical.

Exploring CHIR99021: The Key to Stem Cell Research and Beyond

20 November 2023

CHIR 99021 effects on Wnt/β-catenin pathway

Data Privacy and Protection in AI for Precision Medicine

31 October 2023

Discover how AI is revolutionizing data protection and security in precision medicine.

Bias in AI for precision medicine

02 October 2023

Without proper and due consideration in the design and delivery of new therapies and diagnostics, there is a risk that biased datasets will skew outcomes towards certain groups.

Outsourcing AI-assisted clinical trial analytics software: what to consider

29 August 2023

Outsourcing clinical trial analytics? Choose a vendor that prioritizes security, data quality, and model explainability.

Editing B2M and CIITA to Create Hypoimmune Cell Lines for Cell Therapy

29 August 2023

Gene editing is a viable approach for reducing immunogenicity of iPSC-derived therapeutic cells. The B2M and CIITA HLA-regulatory genes are good targets.

Clinical trial analytics using AI: everything you need to know

14 August 2023

Explore the power of clinical trial analytics in shaping healthcare. Learn about data insights, machine learning, bias, and ethical considerations

Why do patients respond differently to drugs? AI may provide an answer

05 May 2023

Learn how artificial intelligence combined with human tissue testing could help us understand why patients respond to drugs differently.

Wire myography: the ultimate guide (protocol included)

25 April 2023

Learn how to measure the reactivity and functional response of arteries in the wire myograph system in our wire myograph protocol.

Alternative testing methods covered by the FDA Modernization Act 2.0

06 March 2023

Discover whether the FDA Modernization Act 2.0. will increase the use of non-animal, alternative testing methods in drug development.

Everything you need to know about the motilin receptor

21 February 2023

Explore the function, physiology, & pharmacology of the motilin receptor. Discover what models can be used to investigate motilin mimetics preclinically.

Make a Difference with Fresh Residual Human Tissue Donation for Research – How to Get Involved!

31 January 2023

Discover the importance of fresh human tissue to healthcare development. Explore some of the options to donate residual tissue to pharmaceutical research.

Clinical Trials: An Evolutionary Perspective

18 January 2023

Find out how clinical trial systems and processes have developed and evolved during human history.

From rat aorta to resistance arteries: measuring vascular contractility

16 January 2023

Explore how isolated blood vessels can be used to determine drug behavior and discover translational alternatives to measuring vascular tone in rat aorta.

Recombinant Human Laminins and their Use in Cell Culture

05 January 2023

Discover the biological processes that laminin regulates. Learn more about the use of laminin in stem cell research and culture.

Everything we know about resistance arteries

21 November 2022

Learn about the physiology of resistance arteries in health and disease. Discover why they are important for controlling blood flow to vital organs.

Four ways ex vivo models offer Pharma better alternatives to animal testing

01 November 2022

Learn more about ex vivo models, and how these under-appreciated systems are helping Pharma reduce animal testing.

How to isolate PBMCs from whole blood using density gradient centrifugation

19 October 2022

Find out how to isolate PBMCs from whole blood samples using density gradient centrifugation a.k.a. the Ficoll Overlay method.

REPROCELL’s Stemgent Brings mRNA Reprogramming to the Clinical Sector

14 October 2022

Discover how REPROCELL has employed its StemRNA™ 4th Generation Reprogramming Technology to bring the power of mRNA reprogramming to the clinical sector.

Everything we know about the human relaxin peptide family

28 September 2022

Discover the physiology and pharmacology of the human relaxin peptide family and their analogs. Learn about the role of human tissue in ex vivo research.

Endogenous and exogenous affectors of uterine contractility

27 September 2022

Discover everything you need to know about ex vivo uterine contractility models. Learn about the use of uterine tissue in drug development and research.

How human fresh tissue models are helping RCD405 achieve regulatory approval

17 August 2022

Discover how Arcede Pharma recently used human tissue testing to generate preclinical efficacy data for their compound RCD405.

What are PBMCs? Everything you need to know about Peripheral Blood Mononuclear Cells

10 August 2022

PBMC is short for Peripheral Blood Mononuclear Cell, or any blood cell with a single nucleus. Many of our immune cells are PBMCs, including lymphocytes.

Protocol for buffy coat preparation from whole blood

09 August 2022

Read our simple, three-step protocol for buffy coat preparation from whole blood. Learn how you can isolate the buffy-coat from whole blood samples.

Protocol for PBMC isolation from buffy coat samples

09 August 2022

Learn how to isolate Peripheral Blood Mononuclear Cells (PBMCs) from buffy coat samples. Discover a protocol for the isolation and counting of PBMCs.

REPROCELL: What makes our human tissue biorepository stand out?

04 August 2022

Disocver REPROCELL, a leader in its industry located in Maryland that is home to over 600,000 biospecimens collected from approximately 120,000 donors.

The ultimate guide to non-animal cardiovascular safety pharmacology

03 August 2022

Discover examples of receptors that are flagged during receptor binding studies and which can then be explored through functional assays.

Everything you need to know about the 5-HT2B receptor

01 July 2022

Explore the key physiological and pharmacological features of the 5-HT2B receptor plus its long and complicated relationship with cardiotoxicity.

Limitations of the isolated perfused heart and alternative models

24 May 2022

Discover the various limitations of the isolated perfused heart model, and human, ex vivo alternatives you can incorporate into your research instead.

Everything we know about the 5-HT2A (serotonin) receptor

04 May 2022

Read our ultimate guide to the 5-HT2A serotonin receptor. Discover the pharmacology and physiology of 5-HT2A in the nervous and cardiovascular systems.

Everything we know about the 5-HT1B receptor

21 April 2022

Discover everything scientists know, so far, about the pharmacology, molecular structure, and function of the human 5HT1B and 5HT1D receptor.

Skin biopsy and ex vivo culture methods

29 March 2022

Looking for skin biopsy and ex vivo culture methods to use in your research? Discover a range of ex vivo and in vitro skin models outlined in this article.

The influence of the microbiome on inflammatory bowel disease

18 March 2022

Learn about the the influence of the gut microbiome on inflammatory bowel disease (IBD) and how precision medicine may change the way we treat IBD.

What is Human Tissue Testing?

14 March 2022

Discover the definition of human tissue testing and how it can enhance your drug discovery research on the REPROCELL blog.

REPROCELL Solutions for Skin Disease Researchers

04 March 2022

Looking to outsource your skin disease research? Discover REPROCELL's range of solutions for skin disease researchers today.

Predicting Psoriasis Drug Efficacy in Human Skin [Infographic]

03 March 2022

View our infographic and discover how REPROCELL scientists helped Pharma to predicting psoriasis drug efficacy in human skin biopsies.

Inserts or plates for your 3D cell culture?

28 February 2022

Struggling to decide between inserts or plates for your 3D cell culture? Visit our blog and discover how to choose the best 3D system for your research.

How to improve your 3D Cell Culture using Small-scale Perfusion Systems

15 February 2022

Discover how to improve your 3D cell culture using small-scale perfusion systems on the REPROCELL blog.

Enhance your epithelial barriers assay using Alvetex®

07 February 2022

Looking to improve the translatability of your epithelial models? Find out how to enhance your epithelial barriers assay using Alvetex.

Everything you need to know about the REPROCELL iPSC Biobank

30 November 2021

Interested in learning about our off-the-shelf iPSCs? Read our blog article and discover everything you need to know about the REPROCELL iPSC Biobank.

How we established an in vitro Parkinson’s Disease model

24 November 2021

Discover how to establish an in vitro Parkinson’s Disease model using iPSC-derived neurons - from patient screening to neuronal maturation.

How digital droplet PCR can improve CRISPR gene editing (with examples)

05 October 2021

Looking to understand how digital PCR can improve your genome editing projects? Learn how digital PCR can improve your CRISPR gene editing (with examples).

What is digital droplet PCR and how can it improve stem cell therapies?

13 September 2021

Discover the definition of digital droplet PCR and how can it improve the safety of your stem cell therapies.

The ultimate guide to REPROCELL’s GMP iPSC manufacturing service

09 September 2021

Find out everything you need to know about REPROCELL's clinical stem cell services in our ultimate guide to REPROCELL’s GMP iPSC manufacturing service.

The ultimate guide to REPROCELL’s stem cell research services

16 August 2021

Looking to outsource your stem cell research project? Discover everything you need to know in our ultimate guide to REPROCELL’s stem cell research services

Will mRNA change medicine for good?

12 August 2021

Find out if mRNA will change medicine for good. Read about the molecules rise to fame in 2020 and how it could be used to treat diseases such as cancer.

Our top 10 stem cell culture products

02 July 2021

Read our countdown of the op 10 stem cell culture products sold by REPROCELL as chosen by our customers.

Human tissue testing and precision medicine

08 June 2021

Find out how a recent nature article has sparked interest in the use of human tissue testing for precision medicine.

The ultimate guide to Alvetex

31 May 2021

Find out everything you need to know about Alvetex technology in our ultimate guide to Alvetex.

How to bioengineer epithelial tissues in vitro

25 May 2021

Looking to bioengineer epithelial tissues in vitro? Find out how Alvetex can be used to create full-thickness epithelial tissues on the REPROCELL blog.

Improving precision medicine strategies with human tissue testing

29 April 2021

Discover how you can improve your precision medicine strategies with human tissue testing.

Precision medicine for the COVID-19 pandemic

03 February 2021

Learn how precision medicine could help to end the COVID-19 pandemic by accelerating the processes of understanding and treating disease.

Protocol for immunocytochemistry of stem cells

29 January 2021

Read our tried-and-tested protocol for immunocytochemistry of stem cells and optimize your antibody concentrations.

Five reasons to choose StemRNA 3rd Gen Reprogramming Technology

04 December 2020

Looking for a more efficient iPSC reprogramming kit? Discover five reasons you should choose StemRNA 3rd Gen Reprogramming Technology for iPSC generation.

What is Translational Science?

11 September 2020

Discover the definition of translational research and how it can improve drug discovery and development programs.

This light-activated treatment could help patients with peripheral artery disease [Interview]

01 September 2020

Discover how this light-activated treatment could help patients with peripheral artery disease in this interview with the researchers.

Four Examples of human models of respiratory diseases

03 August 2020

Looking for human models of respiratory diseases? Find 4 examples of translational respiratory disease models on the REPROCELL blog.

Using 3D culture to improve Caco-2 permeability assays

14 July 2020

Looking to elevate your permeability projects? Find out how you can use 3D culture to improve your Caco-2 permeability assays from REPROCELL.

CRISPR-Cas9: Big Data, Precision Medicine and Universal Cell Therapy

13 April 2020

Find out how CRISPR-Cas9 can enhance big data, precision medicine, and universal cell therapy on the REPROCELL blog.

How to Characterize the Barrier Properties of Alvetex®-Based Mucosal Models

06 April 2020

Find out how to Characterize the Barrier Properties of your Alvetex®-Based Mucosal Models on the REPROCELL blog.

How CRISPR-SNIPER compares to other gene editing techniques

01 April 2020

Want to find out how CRISPR-SNIPER compares to other gene editing techniques? Discover the benefits of this advanced editing system on the REPROCELL blog.

A Visual Guide to CRISPR-SNIPER Gene Editing [Infographic]

30 March 2020

Discover the benefits of our advanced genome editing system in this visual guide to CRISPR-SNIPER gene editing [INFOGRAPHIC].

How is Stemchymal® performing in Clinical Trials? [Infographic]

16 March 2020

Wondering how is Stemchymal® performing in Clinical Trials? Discover the main findings from Stemchymal's clinical trials in our infographic.

Three challenges facing the introduction of iPSC-derived therapies

12 February 2020

Discover three of the main challenges facing the introduction of iPSC-derived therapies on the REPROCELL blog.

Four ways stem cells can be used in medical treatments

12 February 2020

Looking to find out how stem cells be used in medical treatments? Find 4 ways stem cells can be used therapeutically on the REPROCELL blog.

Five Benefits of Precision Medicine

07 February 2020

Find out the top 5 benefits of precision medicine, to drug developers to patients, on the REPROCELL blog.

Four reasons human tissues should be used to predict drug bioavailability

29 January 2020

Find out why human tissues should be used to predict drug bioavailability and permeability on the REPROCELL blog.

How to estimate drug permeability using the Ussing Chamber technique

22 January 2020

Looking to estimate drug permeability using the Ussing Chamber technique? Find out how on the REPROCELL blog.

Cost Effective, Lab-scale Spheroid Culture of iPSCs

21 January 2020

Looking for cost effective, lab-scale, spheroid culture of iPSCs? Discover how the ABLE Bioreactor enables smarter cell production - no experience needed.

4 TED Talks discussing the future of regenerative medicine

19 December 2019

Learn about the current limitations facing the future of regenerative medicine through these four TED Talks.

Stem cells offer hope for sufferers of Spinocerebellar Ataxia

08 November 2019

Discover how stem cell treatments can offer hope for sufferers of Spinocerebellar Ataxia (SCA).

How to mass culture induced pluripotent stem cells (iPSCs) using the ABLE Bioreactor System

30 October 2019

Discover how to mass culture induced pluripotent stem cells (iPSCs) in spheroids using the ABLE Bioreactor System.

Improve Gene-Editing Success with CRISPR-SNIPER Technology

29 October 2019

The Ultimate Guide to CRISPR-SNIPER technology: a gene-editing system that overcomes the limitations of conventional CRISPR systems.

What are the advantages of an internship to employers?

23 October 2019

Find out the advantages of an internship to employers on the REPROCELL blog. Discover how hiring an intern can benefit your company and employees.

Which stem cell reprogramming technology should I use?

17 October 2019

Wondering which stem cell reprogramming technology you should use for your iPSC project? Discover the pros and cons of RNA Reprogramming from REPROCELL.

IBDiscovery: Combining patient and drug discovery data to transform healthcare

16 September 2019

Learn how REPROCELL's IBDisocvery project is combining patient and drug discovery data to transform healthcare.

What is CRISPR-SNIPER Gene Editing?

02 September 2019

Discover the definition of CRISPR-SNIPER and how this advanced gene editing system can improve your edits.

Machine Learning and Big Data in Precision Medicine

08 August 2019

Discover how machine learning and big data can be used in precision medicine to cut costs, reduce errors and gain faster drug approvals.

Pluripotent Potential for Clinical Application

25 July 2019

Discover the potential of induced pluripotent stem cells (iPSCs) for clinical application on the REPROCELL blog.

An Improved Model for IBD Drug Discovery

11 July 2019

Looking to find an improved model for IBD drug discovery? Find out the benefits of human tissue testing on the REPROCELL blog.

Advances in diagnostics, treatments, and frontiers of research in IBD

13 June 2019

Find out the latest advances in diagnostics, treatments, and frontiers of research in IBD on the REPROCELL blog.

How Human Organoculture can Improve Precision Medicine Strategies

05 June 2019

Discover how human organoculture can be used to improve precision medicine strategies on the REPROCELL blog.

Will The Microbiome Become The Next Hot Topic For Cancer Research?

16 May 2019

Discover whether the microbiome will become the next hot topic for cancer research on the REPROCELL blog.

REPROCELL Solutions for Respiratory Disease Researchers

29 April 2019

Looking to outsource your respiratory disease research? Find out more about REPROCELL's solutions for respiratory disease researchers.

Stem Cells for Autism

03 April 2019

Visit the REPROCELL blog and find out how stem cells could be used to treat autism in the future.

Neurite Outgrowth Assays using StemRNA Neuro

20 March 2019

Find out more about REPROCELL's neurite outgrowth assay that uses StemRNA Neuro cells.

Using human iPSCs as an in vitro model for regenerative medicine and disease modelling

22 February 2019

The conventional drug discovery pathway is a very inefficient process with the majority of candidate drugs not reaching the market due to safety and/or efficacy issues. But the use of iPSCs allows high throughput screening of therapies and disease-specific treatment using patient-specific models.

The gut microbiome in health and disease: the future for diagnosis and treatment of IBD and IBS?

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