Cellular Services
Expert Cell Isolation and Primary Cell Derivation from Human Biospecimens
REPROCELL provides specialised cellular services, including cell isolation, enrichment, and primary cell derivation from a wide range of human biospecimens. These services support translational research, drug discovery, and clinical research studies by delivering high-quality, physiologically relevant cell populations for downstream applications.
With more than 20 years of experience and 24/7 GCLP-compliant laboratory operations, we deliver reliable, consistent processing for even the most time-critical clinical projects.
Cell Isolation and Enrichment
Efficient cell isolation and enrichment are essential steps in many clinical sample processing workflows. Selecting the appropriate approach is critical to maintaining the purity, viability, and functionality of target cell populations for downstream applications.
We provide flexible solutions designed around your sample type, study objectives, and clinical research requirements, including:
- Isolation of specific immune cell subtypes:
- T cells, B cells, NK cells
- Monocytes and macrophages
- Enrichment of haematopoietic stem and progenitor cells
- Processing of heterogeneous cell populations from blood and tissue samples
Magnetic Cell Isolation
Our magnetic bead-based cell isolation platforms enable precise enrichment or depletion of target cell populations using specific cell surface markers.
Capabilities include:
- Positive selection for target cell capture
- Negative selection for untouched cell populations
- High purity and viability for downstream applications
These approaches are widely used across immunology, cell-based assays, translational research, human tissue models, and disease relevant functional studies.
Figure 1: An infographic showing the process of magnetic cell isolation.
Figure 2: An infographic showing the process of nonmagnetic cell isolation.
Primary Cell Derivation
We provide robust and reliable primary cell derivation services, generating high-quality cell populations directly from fresh human biospecimens.
Primary cells more closely reflect native human biology than immortalised cell lines, making them highly valuable for applications such as:
- Disease modelling
- Drug discovery and drug screening
- Multi-omic profiling and biomarker analysis
Our scientists have experience working with a variety of starting materials, including:
- Whole blood
- Skin tissue
- Urine and other human biospecimens
We deliver low-passage, non-modified primary cells from both healthy and diseased donors, helping to preserve physiological relevance and support translational and clinical research outcomes.
Cell Derivation Methods
Our primary cell isolation workflows are tailored to the biospecimen type and specific research objectives, using established and optimised methodologies to ensure high-quality cell recovery.
Density Gradient Centrifugation
Density gradient centrifugation is a widely used and reliable method for isolating mononuclear cells from blood-derived samples.
Key benefits include:
- Efficient isolation of PBMCs and CBMCs
- Compatible with a broad range of sample volumes
- Rapid processing times, typically within 2–4 hours
- High cell viability and recovery rates
Tissue Dissociation and Cell Culture
For solid tissues such as skin tissue, we apply enzymatic and chemical dissociation techniques to isolate key cell types, including:
- Keratinocytes
- Melanocytes
- Dermal fibroblasts
Following isolation:
- Cells are expanded in controlled culture systems
- Cryopreserved at low passage numbers
- Available for downstream applications, including 2D and 3D models
Flexible, High-Quality Cellular Solutions
We understand that every clinical project has unique scientific and operational requirements. Our cellular services are designed to be flexible and scalable, whether you require standalone cell isolation or fully integrated support through our central laboratory and clinical trial laboratory services.
To further support your clinical research objectives, we offer a range of downstream capabilities, including biomarker discovery and validation, helping maximise the value and insight obtained from every sample.
Support Your Research with Human-Relevant Cells
By combining expert cell isolation, enrichment, and primary cell derivation, REPROCELL enables researchers to generate reliable, high-quality translational data from human-derived cell populations.