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Cellular Services

Expert Cell Isolation and Primary Cell Derivation from Human Biospecimens

REPROCELL provides specialised cellular services, including cell isolation, enrichment, and primary cell derivation from a wide range of human biospecimens. These services support translational research, drug discovery, and clinical research studies by delivering high-quality, physiologically relevant cell populations for downstream applications.

With more than 20 years of experience and 24/7 GCLP-compliant laboratory operations, we deliver reliable, consistent processing for even the most time-critical clinical projects.

Cell Isolation and Enrichment

Efficient cell isolation and enrichment are essential steps in many clinical sample processing workflows. Selecting the best approach is critical to maintaining the purity, viability, and functionality of target cell populations for downstream applications.

We provide flexible solutions designed around your sample type, study objectives, and clinical research requirements.

Magnetic Cell Isolation

Our magnetic bead-based cell isolation platforms enable precise enrichment or depletion of immune cell populations using specific cell surface markers (T cells, B cell, NK cells, monocytes, macrophages).

Capabilities include:

  • Positive selection for target cell capture
  • Negative selection for untouched cell populations
  • High purity and viability for downstream applications

Non-Magnetic Cell Selection

Our immunodensity approach is applied directly to fresh whole blood samples to isolate immune cell subsets of interest.  The approach is based on the following:

  • Negative selection
  • Antibody labelling and red blood cell rosetting
  • Integration with a density gradient centrifugation protocol

These approaches are widely used across immunology, cell-based assays, translational research, human tissue models, and disease relevant functional studies.

Clinical Drug Discovery - the process of magnetic cell isolation

Figure 1: An infographic showing the process of magnetic cell isolation.

Clinical Drug Discovery - nonmagnetic cell isolation

Figure 2: An infographic showing the process of nonmagnetic cell isolation.

Primary Cell Derivation

We provide robust and reliable primary cell derivation services, generating high-quality cell populations direct from fresh human biospecimens.

Our expertise enables the isolation and delivery of low-passage, non-modified primary cells from both healthy and diseased donors, helping to preserve physiological relevance and enhance the predictive value of translational and clinical research.

Each primary cell isolation workflow is tailored to the biospecimen type and specific study objectives. By combining established protocols with optimised methodologies, we maximise cell yield, viability, and purity while ensuring the recovery of high-quality cell populations suitable for a wide range of downstream applications.

Density Gradient Centrifugation

Density gradient centrifugation is a widely used and reliable method for isolating mononuclear cells from blood-derived samples.

Key benefits include:

  • Efficient isolation of PBMCs
  • Compatible with a broad range of sample volumes
  • Rapid processing times
  • High cell viability and recovery rates
Density gradient centrifugation of whole blood

Tissue Dissociation and Cell Culture

For solid tissue specimens such as skin, we employ enzymatic and chemical dissociation protocols to isolate and recover key primary cell populations, including:

  • Keratinocytes
  • Melanocytes
  • Dermal fibroblasts

Following isolation, cells are:

  • Expanded under controlled culture conditions
  • Cryopreserved at low passage numbers to preserve physiological relevance
  • Available for a wide range of downstream applications, including both 2D and advanced 3D tissue models
Sara B-M in Safety Cabinet

Flexible, High-Quality Cellular Solutions

We understand that every clinical project has unique scientific and operational requirements. Our cellular services are designed to be flexible and scalable, whether you require standalone cell isolation or fully integrated support through our central laboratory and clinical trial laboratory services.

To further support your clinical research objectives, we offer a range of downstream capabilities, including biomarker discovery and validation, helping maximise the value and insight obtained from every sample.

Support Your Research with Human-Relevant Cells

By combining expert cell isolation, enrichment, and primary cell derivation, REPROCELL enables researchers to generate reliable, high-quality translational data from human tissues

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