Whole Blood Processing and PBMC Isolation

Expert Whole Blood Processing for High-Quality Biospecimens in Clinical Research

REPROCELL provides comprehensive whole blood processing services to support translational and clinical research. Our expertise includes the isolation of peripheral blood mononuclear cells (PBMCs), plasma, and serum, to deliver high-quality biological materials for a wide range of downstream applications.

Peripheral blood processing is a vital first step in many clinical research workflows, enabling the downstream investigation of immune responses, disease-associated biomarkers, and underlying cellular mechanisms. Using robust, standardised procedures, we help ensure sample integrity from collection through processing, supporting the generation of reliable, reproducible clinical data.

Our core clinical and central laboratory services are designed to integrate seamlessly with clinical trial programmes, providing researchers and sponsors with consistent, high-quality starting material to accelerate discovery and improve clinical study outcomes.

Our Capabilities

We provide end-to-end whole blood processing solutions, transforming clinical blood samples into high-quality, application-ready biological materials for basic research, translational, and clinical studies.

Key capabilities include:

Processing of whole blood samples (peripheral and cord)
Isolation of PBMCs, plasma, serum, and other blood derived fractions
Optimised density gradient centrifugation and cellular separation workflows
Immunomagnetic isolation for targeted immune cell subsets
Controlled-rate cryopreservation and secure sample storage
Flexible support for both sponsor-specific and internally validated SOPs

All clinical sample processing is conducted within GCLP-compliant, BSL2 laboratory facilities, by highly trained and experienced scientific personnel. Our controlled workflows ensure sample integrity, reproducibility, and consistency across specimens and studies.

Reliable PBMC Isolation for Translational Research

High quality PBMC isolation is fully integrated within our whole blood processing workflows.

Using optimised density gradient methods, we deliver high-viability, high-purity peripheral mononuclear cells (PBMCs) from anticoagulated peripheral and cord blood samples – supporting reliable downstream biomarker analysis, immunology, and cell-based research applications.

Our PBMC isolation capabilitiesinclude:

Ficoll-Paque™ density gradient isolation
Vacutainer® CPT mononuclear cell preparation tubes
Accuspin™ and SepMate™ PBMC isolation systems
Controlled-rate viable PBMC freezing
Cryostorage and clinical sample management

Our PBMC isolation workflows support:

Recovery of immune cell populations. Our processes enable efficient recovery of key mononuclear cell subsets, including
- T cells
- B cells
- NK cells
- Monocytes
- Dendritic cells
Advanced downstream applications. Our PBMC isolation workflows are designed to support a wide range of applications, including
- Immunology and inflammation studies
- Cell-based functional assays
- Biomarker discovery programmes
- Genomic and translational research

Quality, Speed, and Flexibility

Maintaining biospecimen quality is critical to generating reliable reproducible data. Our blood processing workflows are designed to minimise pre-analytical variability, protect sample integrity, and support confidence in downstream analytical results.

We provide:

Rapid sample processing to minimise sample degradation
Expertise across multiple blood collection tube types and anticoagulants
24/7 laboratory operations for time-sensitive clinical studies
Experienced scientific personnel and validated SOP-driven workflows
Controlled handling procedures to maximise consistency across clinical studies

Our approach ensures maximal sample yield, high cell viability, and improved analytical consistency across all clinical research studies.

Downstream Applications and Analytical Integration

REPROCELL combines high-quality biospecimen processing with downstream analytical capabilities, enabling greater insight and value from every sample.

We provide a range of capabilities, including:

Nucleic acid extraction (DNA and RNA)
Gene expression and genomic analysis (qPCR, RNASeq, genotyping)
Multiplex cytokine and biomarker profiling
Primary cell derivation from blood-derived populations

This comprehensive approach supports the full spectrum of clinical research and clinical trial service requirements while enhancing data quality, consistency, and reproducibility across studies.

A Flexible Partner for Clinical Research

We understand that every study has unique requirements. Our team works closely with you to design customised blood processing and PBMC workflows aligned to your:

Study design and timelines
Target indications
Downstream assays and endpoints

Whether you require standalone blood processing or fully integrated central laboratory services, REPROCELL delivers scalable solutions to support your research.

Maximise the Value of Your Blood Samples

By combining whole blood processing, PBMC isolation, and downstream analytical expertise, REPROCELL helps you generate high-quality, human-relevant data from every sample.

Why partner with us for your PBMC isolation needs?