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Featured Posts

REPROCELL’s Stemgent Brings mRNA Reprogramming to the Clinical Sector

Discover how REPROCELL has employed its StemRNA™ 4th Generation Reprogramming Technology to bring the power of mRNA reprogramming to the clinical sector.

How human fresh tissue models are helping RCD405 achieve regulatory approval

Discover how Arcede Pharma recently used human tissue testing to generate preclinical efficacy data for their compound RCD405.

How to isolate PBMCs from whole blood using density gradient centrifugation

Find out how to isolate PBMCs from whole blood samples using density gradient centrifugation a.k.a. the Ficoll Overlay method.

Clinical Trials: An Evolutionary Perspective

Find out how clinical trial systems and processes have developed and evolved during human history.

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Documentation

Scientific Publications

Recent Papers by REPROCELL Scientists


Alvetex

Disruption of epithelial barrier integrity via altered GILZ/c-Rel/RACK1 signaling in inflammatory bowel disease (IBD)
Erica Buoso, Mirco Masi, Roberta Valeria Limosani, Francesca Fagiani, Chiara Oliviero, Giorgia Colombo, Luigi Cari, Marco Gentili, Eleonora Lusenti, Lucrezia Rosati, Federica Pisati, Alessandra Pasini, Marco Vincenzo Lenti, Antonio Di Sabatino, Claire Louise Mobbs, Stefan Przyborski, Simona Ronchetti, Cristina Travelli, Marco Racchi
Journal of Crohn's and Colitis, 18 Dec 2024


Alvetex

Assessing the impact of airborne particulate pollution on human skin utilizing a novel human skin equivalent containing MUTZ-3-derived Langerhans cells
Matthew Freer, Jim Cooper, Kirsty Goncalves, and Stefan Przyborski
Bioengineering and Translational Medicine, 13 Dec 2024


Alvetex

Bioengineering the Human Intestinal Mucosa and the Importance of Stromal Support for Pharmacological Evaluation In Vitro
Matthew Freer, Jim Cooper, Kirsty Goncalves, and Stefan Przyborski
Cells, 8 Nov 2024


Alvetex

Investigation into the significant role of dermal-epidermal interactions in skin ageing utilising a bioengineered skin construct
Lydia Costello, Kirsty Goncalves, Paola De Los Santos Gomez, Ben Hulette, Teresa Dicolandrea, Michael J. Flagler, Robert Isfort, John Oblong, Charlie Bascom, Stefan Przyborski
Journal of Cellular Physiology, 8 Oct 2024


Genomics & molecular services

Mutational landscape of BRCA gene mutations in Indian breast cancer patients: retrospective insights from a diagnostic lab
Rosy Chikkala, Deepak Bhayal, Nikki Rani, Rama Modali, Kishor Bhatia & Bhawna Dubey
Egyptian Journal of Medical Human Genetics


Alvetex

Modulation of the Nogo signaling pathway to overcome amyloid-β-mediated neurite inhibition in human pluripotent stem cell-derived neurites
Kirsty Goncalves, Stefan Przyborski
Neural Regeneration Research


iPSCs

Characterization of human iPSC-derived sensory neurons and their functional assessment using multi electrode array
Minami Hiranuma, Yuichi Okuda, Yuuka Fujii, Jean-Philippe Richard & Tomohisa Watanabe
Scientific Reports


iPSCs

Clinically compatible advances in blood-derived endothelial progenitor cell isolation and reprogramming for translational applications
Sarah Eminli, Baraa Kwieder, Kevin Yi, Christopher JZ Huang, Jung-Il Moon, C-Hong Chang, Fedir N Kiskin, Nicholas W Morrell, Brad Hamilton, Amer A Rana
New Biotechnology


Alvetex

Using Advanced Cell Culture Techniques to Differentiate Pluripotent Stem Cells and Recreate Tissue Structures Representative of Teratoma Xenografts
L A Smith, A Hidalgo Aguilar, D D G Owens, R H Quelch, E Knight and S A Przyborski
Frontiers in Cell Development and Biology


iPSCs

Wnt inhibition facilitates RNA-mediated reprogramming of human somatic cells to naive pluripotency
Nicholas Bredenkamp, Jian Yang, James Clarke, Giuliano Giuseppe Stirparo, Ferdinand von Meyenn, Sabine Dietmann, Duncan Baker, Rosalind Drummond, Yongming Ren, Dongwei Li, Chuman Wu, Maria Rostovskaya, Sarah Eminli-Meissner, Austin Smith, Ge Guo
Stem Cell Reports


Alvetex

Engineering a Multilayered Skin Equivalent: The Importance of Endogenous Extracellular Matrix Maturation to Provide Robustness and Reproducibility
Lydia Costello, Nicola Fullard, Mathilde Roger, Steven Bradbury, Teresa Dicolandrea, Robert Isfort, Charles Bascom, Stefan Przyborski
Skin Tissue Engineering


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