Scientific Publications

Recent Publications by REPROCELL Scientists

Alvetex

Engineering a Pigmented Skin Equivalent That Is Responsive to External Stimuli

Paola De Los Santos Gomez, Kirsty Goncalves, Victoria Maltman, Lucy Smith & Stefan Przyborski
Skin Tissue Engineering
11 April 2025
DOI: 10.1007/978-1-0716-4510-9_9

Alvetex

Engineering a Multilayered Skin Equivalent: The Importance of Endogenous Extracellular Matrix and Model Flexibility for Nuanced and Accurate Skin Studies

Lucy Smith, Victoria Maltman, Paola De Los Santos Gomez, Kirsty Goncalves & Stefan Przyborski
Skin Tissue Engineering
11 April 2025
DOI: 10.1007/978-1-0716-4510-9_12

Alvetex

Disruption of epithelial barrier integrity via altered GILZ/c-Rel/RACK1 signaling in inflammatory bowel disease (IBD)

Erica Buoso, Mirco Masi, Roberta Valeria Limosani, Francesca Fagiani, Chiara Oliviero, Giorgia Colombo, Luigi Cari, Marco Gentili, Eleonora Lusenti, Lucrezia Rosati, Federica Pisati, Alessandra Pasini, Marco Vincenzo Lenti, Antonio Di Sabatino, Claire Louise Mobbs, Stefan Przyborski, Simona Ronchetti, Cristina Travelli, Marco Racchi
Journal of Crohn's and Colitis, 18 Dec 2024
DOI: 10.1002/btm2.10738

Alvetex

Assessing the impact of airborne particulate pollution on human skin utilizing a novel human skin equivalent containing MUTZ-3-derived Langerhans cells

Matthew Freer, Jim Cooper, Kirsty Goncalves, and Stefan Przyborski
Bioengineering and Translational Medicine, 13 Dec 2024
DOI: 10.1002/btm2.10738

Alvetex

Bioengineering the Human Intestinal Mucosa and the Importance of Stromal Support for Pharmacological Evaluation In Vitro

Matthew Freer, Jim Cooper, Kirsty Goncalves, and Stefan Przyborski
Cells, 8 Nov 2024
DOI: 10.3390/cells13221859

Alvetex

Investigation into the significant role of dermal-epidermal interactions in skin ageing utilising a bioengineered skin construct

Lydia Costello, Kirsty Goncalves, Paola De Los Santos Gomez, Ben Hulette, Teresa Dicolandrea, Michael J. Flagler, Robert Isfort, John Oblong, Charlie Bascom, Stefan Przyborski
Journal of Cellular Physiology, 8 Oct 2024
DOI: 10.1002/jcp.31463

Genomics & molecular services

Mutational landscape of BRCA gene mutations in Indian breast cancer patients: retrospective insights from a diagnostic lab

Rosy Chikkala, Deepak Bhayal, Nikki Rani, Rama Modali, Kishor Bhatia & Bhawna Dubey
Egyptian Journal of Medical Human Genetics, 5 September 2024
DOI: 10.1186/s43042-024-00567-6

Alvetex

Modulation of the Nogo signaling pathway to overcome amyloid-β-mediated neurite inhibition in human pluripotent stem cell-derived neurites

Kirsty Goncalves, Stefan Przyborski
Neural Regeneration Research, 29 July 2024
DOI: 10.4103/NRR.NRR-D-23-01628

Alvetex

Cell Senescence-Independent Changes of Human Skin Fibroblasts with Age

Nicola Fullard, James Wordsworth, Ciaran Welsh, Victoria Maltman, Charlie Bascom, Ryan Tasseff, Robert Isfort, Lydia Costello, Rebekah-Louise Scanlan, Stefan Przyborski, and Daryl Shanley
Cells, 9 April 2024
DOI: 10.3390/cells13080659

iPSCs

Characterization of human iPSC-derived sensory neurons and their functional assessment using multi electrode array

Minami Hiranuma, Yuichi Okuda, Yuuka Fujii, Jean-Philippe Richard & Tomohisa Watanabe
Scientific Reports, 12 March 2024
DOI: 10.1038/s41598-024-55602-8

Alvetex

An in vitro model to study immune activation, epithelial disruption and stromal remodelling in inflammatory bowel disease and fistulising Crohn’s disease

Claire L. Mobbs, Nicole J. Darling and Stefan Przyborski
Frontiers in Immunology, 12 February 2024
DOI: 10.3389/fimmu.2024.1357690

ec23

Regulation of epidermal proliferation and hair follicle cycling by synthetic photostable retinoid EC23

Arto Määttä, Rebecca Nixon, Neil Robinson, Carrie A Ambler, Kirsty Goncalves, Victoria Maltman, Stefan Przyborski
J Cosmet Dermatol, 03 January 2023
DOI: 10.1111/jocd.15629

Alvetex

Development of a mammalian neurosensory full-thickness skin equivalent and its application to screen sensitizing stimuli
Freer M, Darling N, Goncalves K, Mills KJ, Przyborski S.
Bioeng Transl Med, January 2023
DOI: 10.1002/btm2.10484

Alvetex

Application of biomimetic surfaces and 3D culture technology to study the role of extracellular matrix interactions in neurite outgrowth and inhibition

K.E.Goncalves, S.Phillips, D.S.H.Shah, D.Athey, S.A.Przyborski
Biomaterials Advances, 23 November 2022
DOI: 10.1016/j.bioadv.2022.213204

Alvetex

Investigation into the effect of skin tone modulators and exogenous stress on skin pigmentation utilizing a novel bioengineered skin equivalent

Kirsty Goncalves, Paola De Los Santos Gomez, Lydia Costello, Lucy Smith, Hugh Mead, Amy Simpson, Stefan Przyborski
Bioengineering and Translational Medicine, 26 September 2022
DOI: 10.1002/btm2.10415

Alvetex

Recreating Tissue Structures Representative of Teratomas In Vitro Using a Combination of 3D Cell Culture Technology and Human Embryonic Stem Cells

Alejandro Hidalgo Aguilar, Lucy Smith, Dominic Owens, Rebecca Quelch, and Stefan Przyborski
Bioengineering 2022, 9(5), 185, 22 April 2022
DOI: 10.3390/bioengineering9050185

iPSCs

Clinically compatible advances in blood-derived endothelial progenitor cell isolation and reprogramming for translational applications

Sarah Eminli, Baraa Kwieder, Kevin Yi, Christopher JZ Huang, Jung-Il Moon, C-Hong Chang, Fedir N Kiskin, Nicholas W Morrell, Brad Hamilton, Amer A Rana
New Biotechnology, 25 July 2021
DOI: 10.1016/j.nbt.2021.02.001

Alvetex

Using Advanced Cell Culture Techniques to Differentiate Pluripotent Stem Cells and Recreate Tissue Structures Representative of Teratoma Xenografts

L A Smith, A Hidalgo Aguilar, D D G Owens, R H Quelch, E Knight and S A Przyborski
Frontiers in Cell Development and Biology, 06 May 2021
DOI: 10.3389/fcell.2021.667246

Alvetex

Use of Porous Polystyrene Scaffolds to Bioengineer Human Epithelial Tissues In Vitro

Costello L, Darling N, Freer M, Bradbury S, Mobbs C, Przyborski S
Methods in Molecular Biology (Clifton, N.J.), 1 January 2021
DOI: 10.1007/978-1-0716-1246-0_20

iPSCs

Protocol: Generation of Human iPSCs by Reprogramming with the Unmodified Synthetic mRNA
Robert R Annand, 24 November 2020

Part of the book series: Methods in Molecular Biology (MIMB), volume 2239

Alvetex

Bioengineering Novel in vitro Co-culture Models That Represent the Human Intestinal Mucosa With Improved Caco-2 Structure and Barrier Function

Nicole J Darling, Claire L Mobbs, Ariana L González-Hau, Matthew Freer and Stefan Przyborski
Frontiers in Bioengineering and Biotechnology, 31 August 2020
DOI: 10.3389/fbioe.2020.00992

Alvetex

Applications of novel bioreactor technology to enhance the viability and function of cultured cells and tissues

H W Hoyle, L A Smith, R J Williams and S A Przyborski
The Royal Society — Interface Focus, 14 February 2020
DOI: 10.1098/rsfs.2019.0090

Alvetex

Dataset supporting “Multiple scattering in scanning helium microscopy”

University of Cambridge, Apollo Repository, 31 January 2020
DOI: 10.17863/CAM.48316