The REPROCELL Blog | Drug Discovery: research, reports and resources

How Biomarkers Are Shaping the Future of Skin Disease Treatment

04 February 2025

Discover how biomarkers are revolutionizing the treatment of skin diseases by enabling more precise and effective therapies.

Redefining Success in IBD Drug Discovery with Human Tissue Models

11 December 2024

Redefining IBD drug discovery with a dual-pronged approach through human bioengineered and fresh tissue.

Key Strategies Central Labs Use to Fast-Track Time to Market

18 November 2024

Learn how central labs use automation, outsourcing, and AI to accelerate drug development, reduce costs, and improve clinical trial accuracy and efficiency.

REPROCELL's Advanced Skin Tissue Engineering

31 October 2024

Discover REPROCELL's pioneering 3D skin tissue engineering, enhancing drug development and skincare research with accurate and robust human skin models.

From Fibroblasts to Cancer-Attacking Cells: Insights from Recent Research on Natural Killer Cells Derived from Clinical Grade iPSCs

16 October 2024

Discover the differentiation potential of induced pluripotent stem cells (iPSC) to cytotoxic NK cells, including recent advancements in research and therapy.

The Power of Human Tissue Models in Preclinical Research

03 October 2024

Discover how human tissue models are transforming drug safety assessments and improving outcomes in preclinical research through real-world case studies.

Understanding Safety Pharmacology in Human Tissues

26 August 2024

Explore the role of safety pharmacology in drug discovery, and the importance of human tissue studies for predicting and mitigating potential effects.

Breaking Ground in Alzheimer’s Research: A New Path to Drug Discovery and Personalized Medicine

22 August 2024

Breaking new ground in Alzheimer's research, a study by Durham University uncovers potential therapeutic targets using advanced stem cell technology.

AI in Drug Discovery: The Role of SHAP in Pharmacology

11 July 2024

Learn how Explainable AI, like SHAP, is transforming drug discovery by providing transparency and clarity in machine learning models.

Harnessing Functional Genomics to Revolutionize Inflammatory Bowel Disease Treatment

07 June 2024

Discover how functional genomics is transforming IBD treatment with groundbreaking research on ETS2's role in inflammation.

Leveraging Human Tissue Models with Preclinical and Drug Discovery CRO

05 April 2024

Our Preclinical and Drug Discovery CRO is transforming the landscape of drug development with new technologies and ethically sourced human tissue models.

Data Privacy and Protection in AI for Precision Medicine

31 October 2023

Discover how AI is revolutionizing data protection and security in precision medicine.

Bias in AI for precision medicine

02 October 2023

Without proper and due consideration in the design and delivery of new therapies and diagnostics, there is a risk that biased datasets will skew outcomes towards certain groups.

Why do patients respond differently to drugs? AI may provide an answer

05 May 2023

Learn how artificial intelligence combined with human tissue testing could help us understand why patients respond to drugs differently.

Wire myography: the ultimate guide (protocol included)

25 April 2023

Learn how to measure the reactivity and functional response of arteries in the wire myograph system in our wire myograph protocol.

Alternative testing methods covered by the FDA Modernization Act 2.0

06 March 2023

Discover whether the FDA Modernization Act 2.0. will increase the use of non-animal, alternative testing methods in drug development.

Everything you need to know about the motilin receptor

21 February 2023

Explore the function, physiology, & pharmacology of the motilin receptor. Discover what models can be used to investigate motilin mimetics preclinically.

Make a Difference with Fresh Residual Human Tissue Donation for Research – How to Get Involved!

31 January 2023

Discover the importance of fresh human tissue to healthcare development. Explore some of the options to donate residual tissue to pharmaceutical research.

Clinical Trials: An Evolutionary Perspective

18 January 2023

Find out how clinical trial systems and processes have developed and evolved during human history.

From rat aorta to resistance arteries: measuring vascular contractility

16 January 2023

Explore how isolated blood vessels can be used to determine drug behavior and discover translational alternatives to measuring vascular tone in rat aorta.

Everything we know about resistance arteries

21 November 2022

Learn about the physiology of resistance arteries in health and disease. Discover why they are important for controlling blood flow to vital organs.

4 ways ex vivo models offer Pharma better alternatives to animal testing

01 November 2022

Learn more about ex vivo models, and how these under-appreciated systems are helping Pharma reduce animal testing.

How to isolate PBMCs from whole blood using density gradient centrifugation

19 October 2022

Find out how to isolate PBMCs from whole blood samples using density gradient centrifugation a.k.a. the Ficoll Overlay method.

Everything we know about the human relaxin peptide family

28 September 2022

Discover the physiology and pharmacology of the human relaxin peptide family and their analogs. Learn about the role of human tissue in ex vivo research.

Endogenous and exogenous affectors of uterine contractility

27 September 2022

Discover everything you need to know about ex vivo uterine contractility models. Learn about the use of uterine tissue in drug development and research.

How human fresh tissue models are helping RCD405 achieve regulatory approval

17 August 2022

Discover how Arcede Pharma recently used human tissue testing to generate preclinical efficacy data for their compound RCD405.

What are PBMCs? Everything you need to know about Peripheral Blood Mononuclear Cells

10 August 2022

PBMC is short for Peripheral Blood Mononuclear Cell, or any blood cell with a single nucleus. Many of our immune cells are PBMCs, including lymphocytes.

Protocol for buffy coat preparation from whole blood

09 August 2022

Read our simple, three-step protocol for buffy coat preparation from whole blood. Learn how you can isolate the buffy-coat from whole blood samples.

Protocol for PBMC isolation from buffy coat samples

09 August 2022

Learn how to isolate Peripheral Blood Mononuclear Cells (PBMCs) from buffy coat samples. Discover a protocol for the isolation and counting of PBMCs.

Ultimate guide to nonanimal cardiovascular safety pharmacology

03 August 2022

Discover examples of receptors that are flagged during receptor binding studies and which can then be explored through functional assays.

Everything you need to know about the 5-HT2B receptor

01 July 2022

Explore the key physiological and pharmacological features of the 5-HT2B receptor plus its long and complicated relationship with cardiotoxicity.

Limitations of the isolated perfused heart and alternative models

24 May 2022

Discover the various limitations of the isolated perfused heart model, and human, ex vivo alternatives you can incorporate into your research instead.

Everything we know about the 5-HT2A (serotonin) receptor

04 May 2022

Read our ultimate guide to the 5-HT2A serotonin receptor. Discover the pharmacology and physiology of 5-HT2A in the nervous and cardiovascular systems.

Everything we know about the 5-HT1B receptor

21 April 2022

Discover everything scientists know, so far, about the pharmacology, molecular structure, and function of the human 5HT1B and 5HT1D receptor.

Skin biopsy and ex vivo culture methods

29 March 2022

Looking for skin biopsy and ex vivo culture methods to use in your research? Discover a range of ex vivo and in vitro skin models outlined in this article.

The influence of the microbiome on inflammatory bowel disease

18 March 2022

Learn about the the influence of the gut microbiome on inflammatory bowel disease (IBD) and how precision medicine may change the way we treat IBD.

What is Human Tissue Testing?

14 March 2022

Discover the definition of human tissue testing and how it can enhance your drug discovery research on the REPROCELL blog.

REPROCELL Solutions for Skin Disease Researchers

04 March 2022

Looking to outsource your skin disease research? Discover REPROCELL's range of solutions for skin disease researchers today.

Predicting Psoriasis Drug Efficacy in Human Skin [INFOGRAPHIC]

03 March 2022

View our infographic and discover how REPROCELL scientists helped Pharma to predicting psoriasis drug efficacy in human skin biopsies.

Inserts or plates for your 3D cell culture?

28 February 2022

Struggling to decide between inserts or plates for your 3D cell culture? Visit our blog and discover how to choose the best 3D system for your research.

How to improve your 3D Cell Culture using Small-scale Perfusion Systems

15 February 2022

Discover how to improve your 3D cell culture using small-scale perfusion systems on the REPROCELL blog.

Enhance your epithelial barriers assay using Alvetex®

07 February 2022

Looking to improve the translatability of your epithelial models? Find out how to enhance your epithelial barriers assay using Alvetex.

How we established an in vitro Parkinson’s Disease model

24 November 2021

Discover how to establish an in vitro Parkinson’s Disease model using iPSC-derived neurons - from patient screening to neuronal maturation.

Human tissue testing and precision medicine

08 June 2021

Find out how a recent nature article has sparked interest in the use of human tissue testing for precision medicine.

The ultimate guide to Alvetex

31 May 2021

Find out everything you need to know about Alvetex technology in our ultimate guide to Alvetex.

How to bioengineer epithelial tissues in vitro

25 May 2021

Looking to bioengineer epithelial tissues in vitro? Find out how Alvetex can be used to create full-thickness epithelial tissues on the REPROCELL blog.

Precision medicine for the COVID-19 pandemic

03 February 2021

Learn how precision medicine could help to end the COVID-19 pandemic by accelerating the processes of understanding and treating disease.

What is Translational Science?

11 September 2020

Discover the definition of translational research and how it can improve drug discovery and development programs.

This light-activated treatment could help patients with peripheral artery disease [INTERVIEW]

01 September 2020

Discover how this light-activated treatment could help patients with peripheral artery disease in this interview with the researchers.

4 Examples of human models of respiratory diseases

03 August 2020

Looking for human models of respiratory diseases? Find 4 examples of translational respiratory disease models on the REPROCELL blog.

Using 3D culture to improve Caco-2 permeability assays

14 July 2020

Looking to elevate your permeability projects? Find out how you can use 3D culture to improve your Caco-2 permeability assays from REPROCELL.

How to Characterize the Barrier Properties of Alvetex®-Based Mucosal Models

06 April 2020

Find out how to Characterize the Barrier Properties of your Alvetex®-Based Mucosal Models on the REPROCELL blog.

4 reasons human tissues should be used to predict drug bioavailability

29 January 2020

Find out why human tissues should be used to predict drug bioavailability and permeability on the REPROCELL blog.

How to estimate drug permeability using the Ussing Chamber technique

22 January 2020

Looking to estimate drug permeability using the Ussing Chamber technique? Find out how on the REPROCELL blog.

IBDiscovery: Combining patient and drug discovery data to transform healthcare

16 September 2019

Learn how REPROCELL's IBDisocvery project is combining patient and drug discovery data to transform healthcare.

An Improved Model for IBD Drug Discovery

11 July 2019

Looking to find an improved model for IBD drug discovery? Find out the benefits of human tissue testing on the REPROCELL blog.

Advances in diagnostics, treatments, and frontiers of research in IBD

13 June 2019

Find out the latest advances in diagnostics, treatments, and frontiers of research in IBD on the REPROCELL blog.

How Human Organoculture can Improve Precision Medicine Strategies

05 June 2019

Discover how human organoculture can be used to improve precision medicine strategies on the REPROCELL blog.

Will The Microbiome Become The Next Hot Topic For Cancer Research?

16 May 2019

Discover whether the microbiome will become the next hot topic for cancer research on the REPROCELL blog.

REPROCELL Solutions for Respiratory Disease Researchers

29 April 2019

Looking to outsource your respiratory disease research? Find out more about REPROCELL's solutions for respiratory disease researchers.

Using human iPSCs as an in vitro model for regenerative medicine and disease modelling

22 February 2019

The conventional drug discovery pathway is a very inefficient process with the majority of candidate drugs not reaching the market due to safety and/or efficacy issues. But the use of iPSCs allows high throughput screening of therapies and disease-specific treatment using patient-specific models.

The gut microbiome in health and disease: the future for diagnosis and treatment of IBD and IBS?

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