The REPROCELL Blog | Drug Discovery: research, reports and resources

More Than Half a Century of Drug Development Attrition: Why Better Human-Relevant Models Are Needed

Explore the urgent need for human-relevant models in drug development to reduce high clinical attrition rates and improve patient outcomes.

03 September 2026

The Resurgence of New Approach Methodologies (NAMs) in Drug Discovery and Safety Assessment

Explore how New Approach Methodologies are revolutionizing drug discovery and safety assessment by enhancing human-relevant research and reducing reliance on animal testing.

30 April 2026

Mapping the Competitive Landscape of Human Tissue-Based Drug Discovery

Explore how REPROCELL leads in human tissue-based drug discovery, addressing market gaps and offering innovative, disease-relevant solutions for better therapeutic outcomes.

02 April 2026

Donor Variability in Ex Vivo Human Tissue Studies: Challenge, Feature, or Translational Advantage

Explore how donor variability in ex vivo human tissue studies enhances translational research by providing insights into patient heterogeneity and improving drug discovery.

12 March 2026

Preserving the Microenvironment-Advances in Ex Vivo Colonic Tissue Culture for IBD Drug Discovery

Advances in ex vivo colonic tissue culture preserve the microenvironment, enhancing IBD drug discovery by maintaining native tissue architecture and immune complexity for more predictive research models.

26 February 2026

Modeling Fibrosis Progression Ex Vivo: Opportunities for Anti-Fibrotic Drug Screening

Explore the benefits of ex vivo human tissue models for fibrosis research and anti-fibrotic drug screening, offering a more accurate alternative to conventional preclinical methods.

15 January 2026

Enhancing Experimental Precision with the Alvetex® Advanced Culture System

Discover how Alvetex® Advanced enhances experimental precision with its flexible and functional 3D culture system for creating biologically accurate human skin models.

04 December 2025

Using Ex Vivo Skin Explants to Study Local Immune Responses in Psoriasis and Atopic Dermatitis

Explore the use of ex vivo skin explants to study local immune responses in chronic inflammatory skin diseases like psoriasis and atopic dermatitis.

17 November 2025

The Enduring Value of Organ Baths in Modern Drug Discovery

Discover the enduring value of organ baths in drug discovery and their critical role in ensuring the efficacy and safety of new therapies.

06 November 2025

How Human Tissue Testing Adds Commercial Value for Shareholders

Discover how human tissue testing enhances shareholder value, exploring its impact on drug discovery, precision medicine, and regenerative medicine within the life sciences industry.

03 September 2025

NIH Announces End to Exclusive Funding for Animal Model Research

NIH ends exclusive funding for animal model research, promoting New Approach Methodologies like organ-on-a-chip systems and human tissue testing.

18 August 2025

Subcutaneous Artery Assays Help Us to Understand Blood Pressure Regulation

Explore how subcutaneous artery assays enhance understanding of blood pressure regulation and aid in the development of safer, more effective cardiovascular drugs.

07 July 2025

New Therapeutic Targets: The Role of IL17-Related Genes in Precision Medicine

Discover how IL-17 related genes could revolutionize psoriasis treatment, offering new therapeutic targets and paving the way for precision medicine advancements.

09 June 2025

Balancing Efficacy and Cognitive Health In Bladder Assays

New approaches in OAB treatment focus on balancing efficacy and cognitive health, using alternatives to anticholinergics and personalized medicine to improve patient outcomes.

23 May 2025

Key Strategies Central Labs Use to Fast-Track Time to Market

Learn how central labs use automation, outsourcing, and AI to accelerate drug development, reduce costs, and improve clinical trial accuracy and efficiency.

21 May 2025

How Biomarkers Are Shaping the Future of Skin Disease Treatment

Discover how biomarkers are revolutionizing the treatment of skin diseases by enabling more precise and effective therapies.

04 February 2025

Redefining Success in IBD Drug Discovery with Human Tissue Models

Redefining IBD drug discovery with a dual-pronged approach through human bioengineered and fresh tissue.

11 December 2024

REPROCELL’s Advanced Skin Tissue Engineering

Discover REPROCELL's pioneering 3D skin tissue engineering, enhancing drug development and skincare research with accurate and robust human skin models.

31 October 2024

From Fibroblasts to Cancer-Attacking Cells: Insights from Recent Research on Natural Killer Cells Derived from Clinical Grade iPSCs

Discover the differentiation potential of induced pluripotent stem cells (iPSC) to cytotoxic NK cells, including recent advancements in research and therapy.

16 October 2024

The Power of Human Tissue Models in Preclinical Research

Discover how human tissue models are transforming drug safety assessments and improving outcomes in preclinical research through real-world case studies.

03 October 2024

Understanding Safety Pharmacology in Human Tissues

Explore the role of safety pharmacology in drug discovery, and the importance of human tissue studies for predicting and mitigating potential effects.

26 August 2024

Breaking Ground in Alzheimer’s Research: A New Path to Drug Discovery and Personalized Medicine

Breaking new ground in Alzheimer's research, a study by Durham University uncovers potential therapeutic targets using advanced stem cell technology.

22 August 2024

AI in Drug Discovery: The Role of SHAP in Pharmacology

Learn how Explainable AI, like SHAP, is transforming drug discovery by providing transparency and clarity in machine learning models.

11 July 2024

Harnessing Functional Genomics to Revolutionize Inflammatory Bowel Disease Treatment

Discover how functional genomics is transforming IBD treatment with groundbreaking research on ETS2's role in inflammation.

07 June 2024

Leveraging Human Tissue Models with Preclinical and Drug Discovery CRO

Our Preclinical and Drug Discovery CRO is transforming the landscape of drug development with new technologies and ethically sourced human tissue models.

05 April 2024

Data Privacy and Protection in AI for Precision Medicine

Discover how AI is revolutionizing data protection and security in precision medicine.

31 October 2023

Bias in AI for precision medicine

Without proper and due consideration in the design and delivery of new therapies and diagnostics, there is a risk that biased datasets will skew outcomes towards certain groups.

02 October 2023

Why do patients respond differently to drugs? AI may provide an answer

Learn how artificial intelligence combined with human tissue testing could help us understand why patients respond to drugs differently.

05 May 2023

Wire myography: the ultimate guide (protocol included)

Learn how to measure the reactivity and functional response of arteries in the wire myograph system in our wire myograph protocol.

25 April 2023

Alternative testing methods covered by the FDA Modernization Act 2.0

Discover whether the FDA Modernization Act 2.0. will increase the use of non-animal, alternative testing methods in drug development.

06 March 2023

Everything you need to know about the motilin receptor

Explore the function, physiology, & pharmacology of the motilin receptor. Discover what models can be used to investigate motilin mimetics preclinically.

21 February 2023

Make a Difference with Fresh Residual Human Tissue Donation for Research – How to Get Involved!

Discover the importance of fresh human tissue to healthcare development. Explore some of the options to donate residual tissue to pharmaceutical research.

31 January 2023

Clinical Trials: An Evolutionary Perspective

Find out how clinical trial systems and processes have developed and evolved during human history.

18 January 2023

From rat aorta to resistance arteries: measuring vascular contractility

Explore how isolated blood vessels can be used to determine drug behavior and discover translational alternatives to measuring vascular tone in rat aorta.

16 January 2023

Everything we know about resistance arteries

Learn about the physiology of resistance arteries in health and disease. Discover why they are important for controlling blood flow to vital organs.

21 November 2022

Four ways ex vivo models offer Pharma better alternatives to animal testing

Learn more about ex vivo models, and how these under-appreciated systems are helping Pharma reduce animal testing.

01 November 2022

How to isolate PBMCs from whole blood using density gradient centrifugation

Find out how to isolate PBMCs from whole blood samples using density gradient centrifugation a.k.a. the Ficoll Overlay method.

19 October 2022

Everything we know about the human relaxin peptide family

Discover the physiology and pharmacology of the human relaxin peptide family and their analogs. Learn about the role of human tissue in ex vivo research.

28 September 2022

Endogenous and exogenous affectors of uterine contractility

Discover everything you need to know about ex vivo uterine contractility models. Learn about the use of uterine tissue in drug development and research.

27 September 2022

How human fresh tissue models are helping RCD405 achieve regulatory approval

Discover how Arcede Pharma recently used human tissue testing to generate preclinical efficacy data for their compound RCD405.

17 August 2022

What are PBMCs? Everything you need to know about Peripheral Blood Mononuclear Cells

PBMC is short for Peripheral Blood Mononuclear Cell, or any blood cell with a single nucleus. Many of our immune cells are PBMCs, including lymphocytes.

10 August 2022

Protocol for buffy coat preparation from whole blood

Read our simple, three-step protocol for buffy coat preparation from whole blood. Learn how you can isolate the buffy-coat from whole blood samples.

09 August 2022

Protocol for PBMC isolation from buffy coat samples

Learn how to isolate Peripheral Blood Mononuclear Cells (PBMCs) from buffy coat samples. Discover a protocol for the isolation and counting of PBMCs.

09 August 2022

The ultimate guide to non-animal cardiovascular safety pharmacology

Discover examples of receptors that are flagged during receptor binding studies and which can then be explored through functional assays.

03 August 2022

Everything you need to know about the 5-HT2B receptor

Explore the key physiological and pharmacological features of the 5-HT2B receptor plus its long and complicated relationship with cardiotoxicity.

01 July 2022

Limitations of the isolated perfused heart and alternative models

Discover the various limitations of the isolated perfused heart model, and human, ex vivo alternatives you can incorporate into your research instead.

24 May 2022

Everything we know about the 5-HT2A (serotonin) receptor

Read our ultimate guide to the 5-HT2A serotonin receptor. Discover the pharmacology and physiology of 5-HT2A in the nervous and cardiovascular systems.

04 May 2022

Everything we know about the 5-HT1B receptor

Discover everything scientists know, so far, about the pharmacology, molecular structure, and function of the human 5HT1B and 5HT1D receptor.

21 April 2022

Skin biopsy and ex vivo culture methods

Looking for skin biopsy and ex vivo culture methods to use in your research? Discover a range of ex vivo and in vitro skin models outlined in this article.

29 March 2022

The influence of the microbiome on inflammatory bowel disease

Learn about the the influence of the gut microbiome on inflammatory bowel disease (IBD) and how precision medicine may change the way we treat IBD.

18 March 2022

What is Human Tissue Testing?

Discover the definition of human tissue testing and how it can enhance your drug discovery research on the REPROCELL blog.

14 March 2022

REPROCELL Solutions for Skin Disease Researchers

Looking to outsource your skin disease research? Discover REPROCELL's range of solutions for skin disease researchers today.

04 March 2022

Predicting Psoriasis Drug Efficacy in Human Skin [Infographic]

View our infographic and discover how REPROCELL scientists helped Pharma to predicting psoriasis drug efficacy in human skin biopsies.

03 March 2022

Inserts or plates for your 3D cell culture?

Struggling to decide between inserts or plates for your 3D cell culture? Visit our blog and discover how to choose the best 3D system for your research.

28 February 2022

How to improve your 3D Cell Culture using Small-scale Perfusion Systems

Discover how to improve your 3D cell culture using small-scale perfusion systems on the REPROCELL blog.

15 February 2022

Enhance your epithelial barriers assay using Alvetex®

Looking to improve the translatability of your epithelial models? Find out how to enhance your epithelial barriers assay using Alvetex.

07 February 2022

How we established an in vitro Parkinson’s Disease model

Discover how to establish an in vitro Parkinson’s Disease model using iPSC-derived neurons - from patient screening to neuronal maturation.

24 November 2021

Human tissue testing and precision medicine

Find out how a recent nature article has sparked interest in the use of human tissue testing for precision medicine.

08 June 2021

The ultimate guide to Alvetex

Find out everything you need to know about Alvetex technology in our ultimate guide to Alvetex.

31 May 2021

How to bioengineer epithelial tissues in vitro

Looking to bioengineer epithelial tissues in vitro? Find out how Alvetex can be used to create full-thickness epithelial tissues on the REPROCELL blog.

25 May 2021

Precision medicine for the COVID-19 pandemic

Learn how precision medicine could help to end the COVID-19 pandemic by accelerating the processes of understanding and treating disease.

03 February 2021

What is Translational Science?

Discover the definition of translational research and how it can improve drug discovery and development programs.

11 September 2020

This light-activated treatment could help patients with peripheral artery disease [Interview]

Discover how this light-activated treatment could help patients with peripheral artery disease in this interview with the researchers.

01 September 2020

Four Examples of human models of respiratory diseases

Looking for human models of respiratory diseases? Find 4 examples of translational respiratory disease models on the REPROCELL blog.

03 August 2020

Using 3D culture to improve Caco-2 permeability assays

Looking to elevate your permeability projects? Find out how you can use 3D culture to improve your Caco-2 permeability assays from REPROCELL.

14 July 2020

How to Characterize the Barrier Properties of Alvetex®-Based Mucosal Models

Find out how to Characterize the Barrier Properties of your Alvetex®-Based Mucosal Models on the REPROCELL blog.

06 April 2020

Four reasons human tissues should be used to predict drug bioavailability

Find out why human tissues should be used to predict drug bioavailability and permeability on the REPROCELL blog.

29 January 2020

How to estimate drug permeability using the Ussing Chamber technique

Looking to estimate drug permeability using the Ussing Chamber technique? Find out how on the REPROCELL blog.

22 January 2020

IBDiscovery: Combining patient and drug discovery data to transform healthcare

Learn how REPROCELL's IBDisocvery project is combining patient and drug discovery data to transform healthcare.

16 September 2019

An Improved Model for IBD Drug Discovery

Looking to find an improved model for IBD drug discovery? Find out the benefits of human tissue testing on the REPROCELL blog.

11 July 2019

Advances in diagnostics, treatments, and frontiers of research in IBD

Find out the latest advances in diagnostics, treatments, and frontiers of research in IBD on the REPROCELL blog.

13 June 2019

How Human Organoculture can Improve Precision Medicine Strategies

Discover how human organoculture can be used to improve precision medicine strategies on the REPROCELL blog.

05 June 2019

Will The Microbiome Become The Next Hot Topic For Cancer Research?

Discover whether the microbiome will become the next hot topic for cancer research on the REPROCELL blog.

16 May 2019

REPROCELL Solutions for Respiratory Disease Researchers

Looking to outsource your respiratory disease research? Find out more about REPROCELL's solutions for respiratory disease researchers.

29 April 2019

Using human iPSCs as an in vitro model for regenerative medicine and disease modelling

The conventional drug discovery pathway is a very inefficient process with the majority of candidate drugs not reaching the market due to safety and/or efficacy issues. But the use of iPSCs allows high throughput screening of therapies and disease-specific treatment using patient-specific models.

22 February 2019

The gut microbiome in health and disease: the future for diagnosis and treatment of IBD and IBS?

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