We provide a unique combination of services and products to power your translational research
With scientists and laboratories on three continents, REPROCELL has the scientific and clinical expertise to better translate your discoveries into therapies.
REPROCELL’s portfolio includes an extensive product catalog to support stem cell research and 3D bioengineered tissues, a commercial biorepository of ethically-sourced human tissues, extensive clinical networks across the US and Europe that enable our contract research services in human ex vivo living tissues, and our capability to supply induced pluripotent stem cells (iPSCs) for both research and clinical applications
REPROCELL is also developing novel regenerative medicine therapies to treat neurodegenerative disease, based on its expertise in pluripotent stem cells and mesenchymal stem cells, and is currently conducting clinical trials in Japan for the treatment of spinocerebellar ataxia. Its diagnostic services and clinical research services are offered across labs in Japan, the US, UK, and India.
REPROCELL’s expertise in patient recruitment, the logistics, and ethics of accessing human biospecimens and diagnostics is driving the development of new technologies to support biomarker research and precision medicine. Combined with our clinical laboratory facilities, these resources and know-how have positioned REPROCELL as a fully integrated partner for the life sciences industry, with clients across the globe.
Few companies can claim to have such broad business activities and capabilities as REPROCELL, making us a unique partner for you. We can provide the services and materials you need to navigate the complex world of drug discovery and regenerative medicine.
Services and Products
REPROCELL proudly employs over 100 scientists across the USA, UK, and Japan. Every member of our team is recruited for their expertise and interest in stem cells and human tissue research. You can find out a bit more about some of our researchers and their publications below.
Ejaz Ansari, Laboratory Manager and Study Director
Ejaz is one of REPROCELL’s resident experts in human fresh tissue research. As a leading authority in Organ bath and Ussing studies, Ejaz Ansari is Laboratory Manager at our Center for Predictive Drug Discovery.
Bob Annand, Senior Technical Product Manager
Bob has a PhD in biochemistry and over a decade of experience in drug development. He helped to establish and market several of our stem cell products – including the StemRNA 3rd Gen Reprogramming Kit.
Graeme Macluskie, Precision Medicine Director
Since 2011, Graeme has been designing and delivering preclinical research projects globally. With more than two decades of experience in the industry, he leads an R&D team responsible for tissue-based assays.
It is at the core of all we do. Investments in people and infrastructure drive quality thinking, quality products and services, and quality customer and patient experiences.
Technical advancement requires that we remain flexible and agile. We are forward-thinking and embody the process of continuous improvement. We are dedicated to cultivating and commercializing cutting-edge research and advanced medical technologies to improve human health.
As skilled experts, we are trusted partners in our customer’s success. We seek to build and maintain their trust through honest effort, communication, and transparency.
We add value by providing tools and services that de-risk, enable and accelerate customer research workflows and medical healthcare applications.
We help solve critical challenges and provide customized results by listening, designing, and implementing solutions to address the unique needs of our clients
Established in 2003 by preeminent Japanese university researchers, REPROCELL quickly became the leading stem cell research company in Japan. Soon thereafter, REPROCELL products were employed by Professor Shinya Yamanaka during his pioneering research on iPSC technologies at Kyoto University. We were the first company to offer iPSC-derived human cardiomyocytes, hepatocytes, and neuronal cells for research applications and were listed on the Japan JASDAQ / Growth stock market in 2013.
In recent years, REPROCELL has expanded through a series of acquisitions. This expansion has created a workflow – including human tissue acquisition (Bioserve®), RNA reprogramming (Stemgent®), 3D technologies (Reinnervate® – the original manufacturer of Alvetex™), and drug discovery (Biopta®) – in addition to our core capabilities. These acquisitions have been consolidated to regional offices, and the names converted to daughter brands. In the stem cell and drug discovery “market-space”, no other company has such a broad combination of expertise that can be applied to drug discovery and regenerative medicine.
To find out more about REPROCELL’s capabilities, download our Corporate Capabilities Guide (PDF).
2021 – present
May 2021: Completion of administration of Stemchymal to all enrolled patients in phase II clinical trial in Japan.
Apr 2021: Launch of New Testing Service of Identification for Covid-19 Variants.
Mar 2021: Bioserve Biotechnologies India Pvt. Ltd. launches NIPT clinical services in India.
Mar 2021: Launch of PCR Testing Service for COVID-19.
Feb 2021: Patient registration for phase II clinical trial of regenerative therapeutic Stemchymal®.
2011 – 2020
Jul 2020: Launch of Personal iPS Service in Japan
Feb 2020: Phase II clinical trial of regenerative medicine product Stemchymal® - Recruitment of first patient
May 2019: Launch of cGMP suite in Kawasaki to Accelerate Development of iPSC-derived Glial Progenitors for treatment of CNS disorders.
Mar 2019: REPROCELL join Medicines Discovery Catapult’s Virtual R&D network to accelerate drug development.
Feb 2019: Joint venture formed with Fox Chase Cancer Center to begin operations on biosample repositories.
Apr 2018: Acquired BioServe Biotechnologies India Pvt. Ltd.
Oct 2018: Launch of cutting-edge iPS cell genome editing service utilizing next-generation CRISPR/Cas9 technology: CRISP-SNIPER.
Nov 2017: REPROCELL Announces Research Collaboration with Q Therapeutics and Dr Mahendra Rao.
Aug 2017: Official opening of the "Centre for Predictive Drug Discovery" laboratories in Glasgow, Scotland.
May 2017: Alliance is formed with Fox Chase Medical Center (Philadelphia, U.S.A.) to accelerate biomarker and genetic discovery.
Nov 2016: Agreement is signed with Steminent Biopharmaceuticals (Taiwan) for Stemchymal cell therapy technology; REPROCELL Medical business unit is created.
Nov 2016: REPROCELL Europe founded with full-trading offices located at the Biopta site in Glasgow, Scotland (U.K.); Dr. David Bunton named CEO.
Aug 2016:REPROCELL USA founded with full-trading offices located at the BioServe site in Beltsville, MD (U.S.A.); Dr. Rama Modali named CEO.
Nov 2015: Acquired Biopta (Glasgow, Scotland, U.K.)
Oct 2014: REPROCELL USA, the Company’s affiliate in the U.S.A., acquired the business of iPS cell business department of Stemgent (U.S.A.), and changed its name to Stemgent.
Sep 2014: Acquired BioServe (Beltsville, MD, U.S.A.)
Jul 2014: Acquired Reinnervate (County Durham, England, U.K.)
Feb 2014: Consignment and entrustment agreement with Japan Blood Products Organization for the clinical laboratory measurement work.
Feb 2014: Establishment of RC Partners, Inc., which is the Company’s affiliate to invest in a general partner of the venture capital fund called “Cell Innovation Partners, L.P.” that focuses on the creation of next-generation pharmaceutical and medical businesses.
Nov 2013: Launch of custom-made disease model cells in collaboration with Takara Bio, Inc. (Cell products).
Oct 2013: Shin-Yokohama District (REPROCELL, Inc) was chosen as the Life Innovation Comprehensive Special Zones for International Competitiveness Development.
Jun 2013: Listed on the Osaka Securities Exchange JASDAQ Growth Market.
Dec 2012: Establishment of the sales office of REPROCELL USA Inc. in Boston.
Oct 2012: Professor Shinya Yamanaka of Kyoto University received the Nobel Prize in Physiology or Medicine.
Aug 2012: Establishment of the agreement for sales collaboration concerning human iPS cells model for Alzheimer’s disease with PerkinElmer Japan Co., Ltd.
Jun 2012: Launch of human iPSC-derived neuron model cells for Alzheimer’s disease.
May 2012: Human iPSC-derived hepatocytes (ReproHepato) launch.
Oct 2011: A new version of human iPSC-derived cardiomyocytes (ReproCardio2, frozen) launch.
Apr 2011: A new feeder-free culture medium ReproFF2 launched.
Apr 2011: REPROCELL USA, Ltd. established
2003 – 2010
Oct 2010: Human iPSC-derived DA neuron (ReproNeuro DA) launch.
Jan 2010: The headquarters and laboratory have moved to Yokohama.
Apr 2009: Human iPSC-derived cardiomyocytes (ReproCardio) and the assay service using it (QTempo) launch.
Aug 2008: Cardiotoxicity testing (QTempo) using monkey ES cell-derived cardiomyocytes launch.
Jul 2005: National granted project with Kyoto University and pharmaceutical companies “Drug screening and toxicity technology using human ES cells” (2005 to 2010).
Jun 2005: Laboratory installed in Tokyo.
Apr 2005: Launch of research reagent business: Primate ES cell medium.
Aug 2004: Start commercializing Nanog antibodies (human, mouse).
Jun 2003: Joint research agreement with Kyoto University.
May 2003: Joint research agreement with Tokyo University.
Feb 2003: REPROCELL Inc. Established.
Message from our CEO
REPROCELL is going to continue challenging the new horizon of the ES/iPS cell business as a pioneering company.
REPROCELL is a biotech company that was established in 2003 on the basis of technologies developed by Professor Nakatsuji (who had established the first human ES cells in Japan in that year) at Kyoto University and Professor Nakauchi at Tokyo University. The first human ES cells were established at Wisconsin University in 1998, and the first human iPS cells were established at Kyoto University in 2007. Human ES/iPS cell research is still in its early stages, but it is expected to lead to the next generation of life science businesses such as regenerative medicine, tailor-made medicine, and drug development support.
REPROCELL has been playing a pivotal and pioneering role in the ES/iPS cell business by starting to commercialize culture media for human ES/iPS cells in 2005, the world’s first cardiomyocytes derived from human iPS cells in 2009, and the world’s first neurons derived from human iPS cells in 2010. We will continue expanding our business in the field, including the development of culture reagents, stem cell-based drug development support technologies, and tailor-made medicine.
REPROCELL’s company policies are “customer centeredness,” “faith and trust,” and “a frontier spirit.” We believe that the company can exist only by providing value to customers and contributing to society. Toward this purpose, REPROCELL places emphasis on faithfully and bravely taking up new challenges. Through our business, we will contribute to the health and happiness of people worldwide.
Chief Executive Officer
Chikafumi Yokoyama, Ph.D.
Chief Executive Officer
Dr. Yokoyama joined REPROCELL Inc. in 2004 as a general manager of business development, a year after the formation of the company. Since 2005 he has been the Chief Executive Officer during which time he raised investment funds, arranged the initial public offering, and managed several global corporate acquisitions. Prior to REPROCELL, Dr. Yokoyama worked as an RandD Leader for Sumitomo 3M, a subsidiary of 3M Corporation. And earlier, for a period of nearly 8 years, he was employed in McKinsey and Company Inc. as a management consultant. Dr. Yokoyama received his Ph.D. in chemistry from Tokyo University in 1996.
Chief Operating Officer
Mr. Daisuke Usui has global experience in key business position of medical and biotech companies in mature and emerging markets. His diverse background includes various roles managing finance, sales and marketing, supply chain, and launching new products. Prior to joining REPROCELL, Daisuke was responsible for sales and commercial activities in Asia Pacific with HOYA Surgical Optics, in addition to being an executive manager for its subsidiary in India. Daisuke holds a bachelor of arts (International Studies) from Tsukuba University (Japan).
Chief Financial Officer
Mr. Shigetomo Akano has 16 years of financial and accounting experience in Japanese Manufacturing company and BIG4 accounting firm before joining REPROCELL. He worked at Panasonic for 7 years. Meanwhile, he got certifications of Japan and US CPA. Thereafter, he worked at PwC as a manager for 9 years. He has extensive experience in accounting such as Treasury Management, Cost Accounting, Business Plan, Consolidated Accounting and Tax Return, Audit and Accounting advisory regarding cross-border M&A transaction and capital markets. Shigetomo holds a Bachelor of Arts in Policy Management, Keio University (Japan) in 2005.
Mr. Yamakawa has been a non-executive director of REPROCELL since 2008. He is the CEO of HIBIKI Partners, a consulting company, and a BOD member of some listed companies. Having graduated from Waseda University in economics, he started his career as a venture capitalist at Nippon Life Insurance. After experiencing directorship of corporate planning at Innotech Corporation, Mr. Yamakawa joined Sosei Co. Ltd. in 2001 and succeeded in its IPO and MandA as a representative executive officer and CFO.
CEO, REPROCELL USA
CEO, Bioserve Biotechnologies India
Rama Modali is currently the Chief Executive Officer of REPROCELL USA, Ltd. He was the original founder and former President of Bioserve USA, which was acquired by REPROCELL in 2014. Rama has been contributing to the improvement of human health for almost 30 years by providing researchers around the world with access to human tissue samples from diseased donors, clinical collections, and molecular biology services. With a vast international clinical network to leverage, he continues to drive the company’s successful growth under the REPROCELL umbrella through international expansion and the provision of cutting-edge scientific applications to support biomedical research.
Prior to founding Bioserve, Rama was employed at the National Institutes of Health and National Cancer Institute. He has over 32 peer-reviewed research publications.
David Bunton, Ph.D.
CEO, REPROCELL Europe
Dr. David Bunton is CEO of REPROCELL Europe, a life sciences company based in Glasgow, UK, and a subsidiary of REPROCELL Inc. Having founded a human tissue assay service company (Biopta Ltd.) in 2002, Dr. Bunton later took over as the CEO of the conjoint REPROCELL Europe business after the acquisition of Biopta by REPROCELL. The company remains focused on the use of human fresh tissues, 3D models and the use of iPSCs to better characterize drug efficacy and inter-patient variability in drug responses.
Previously a Lecturer at Glasgow Caledonian University, David has numerous publications in physiology and pharmacology to his name and is a respected opinion leader in the use of human tissue for drug discovery. He chairs the Scottish Lifesciences Association’s special interest group in precision medicine, is a member of the NC3Rs/MHRA working party on human tissues in safety pharmacology and is an advocate for the wider global use of human cells and tissues in drug development.
Founders and Advisers
Norio Nakatsuji, Ph.D.
Director, Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University
- Founding director and professor of Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS)
- Director and professor at Institute for Frontier Medical Sciences at Kyoto University
- Professor at National Institute of Genetics
- Principal investigator at the Meiji Institute of Health Science
- Postdoctoral training at Umea University in Sweden, Massachusetts Institute of Technology and George Washington University in the USA, and MRC Mammalian Development Unit in UK.
- Ph.D. from Graduate School of Science, Kyoto University
Hiromitsu Nakauchi, M.D., Ph.D.
Professor and Director, Center for Stem Cell and Regenerative Medicine, Institute of Medical Science, The University of Tokyo
Professor, Department of Genetics, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Professor, Institute of Medical Science, The University of Tokyo
- Professor, Institute of Basic Medical Sciences, University of Tsukuba
- Team leader, Tsukuba Life Science Center, RIKEN
- Assistant professor, Juntendo University School of Medicine
- Post-doctoral research fellow, Stanford University School of Medicine
- Ph.D. from Graduate School of Medicine, The University of Tokyo
- M.D. from Yokohama City University School of Medicine
Hiroyuki Mizuguchi, Ph.D.
Professor, Graduate School of Pharmaceutical Sciences, Osaka University.
- Professor at Graduate School of Pharmaceutical Sciences, Osaka University
- Project Leader at National Institute of Biomedical Innovation
National Institute of Health Sciences
University of Washington
- Ph.D. from Graduate School of Pharmaceutical Sciences, Osaka University
Wado Akamatsu, M.D., Ph.D.
Project Professor, Center for Genomic and Regenerative Medicine, Juntendo University
- Project Professor, Center for Genomic and Regenerative Medicine, Juntendo University
- Assistant Professor, Research Associate, Department of Physiology, Keio University School of Medicine
- Post-Doctoral Fellow, University of Toronto, Medical Genetics and Microbiology
- Research Fellow, Japan Science and Technology Agency
- Research Fellow, Osaka University Hospital
- M.D. and Ph.D. from Graduate School of Medicine, Keio University
Taeko Naruse, Ph.D.
Assistant Professor, Medical Research Institute, Tokyo Medical and Dental University
- Assistant Professor at Medical Research Institute, Tokyo Medical and Dental University
- Research Fellow at Faculty of Medicine, Tokai University
- Research Fellow at Graduate School of Medicine, Osaka City University
- Ph.D. from Graduate School of Medicine, Osaka City University
Hiroshi Yagi, Ph.D.
Lecturer, surgery (general, gastroenterology), Keio University School of Medicine
In charge of hepatobiliary and pancreatic transplantation
- Graduated from Keio University School of Medicine
- Kyoto University Transplant Surgery Medical Associate
- Keio University School of Medicine Surgery (General and Gastroenterology)
- Chief Resident Surgeon of Hino City Hospital
- Doctor of Medicine (Keio University)
- Massachusetts General Hospital Postdoctoral Research Fellow
- Lecturer, Surgery (General and Gastroenterology), Keio University School of Medicine
Over the last decade, REPROCELL has evolved its global infrastructure, corporate organization, and strategy. By leveraging our knowledge base of stem cell technologies, REPROCELL has planned a future that directly involves the pursuit of regenerative medicine market opportunities. This evolution has compelled us to restructure, modify, and define our future vision.
Find out more about the history, philosophy, and business structure of REPROCELL.
Find out more about the services and products we offer to better translate your discoveries into therapies.