Meet us next:   BIO-EUROPE 2025 – 3-5 November  ●  ISSCR International Symposium (Boston) 2025 – 11-12 December  ●  more on our events calendar
Double Staining 2_110SBMC5 A1 NANOG TRA160 5percent X10 DAPI GFP
 

Stemgent™

Well known in the global stem cell research community, the Stemgent brand stands for performance-qualified reagents and innovation.

Products for Stem Cell Research

In 2010, Stemgent was the first company to commercialize mRNA reprogramming. Today, our broad range of products and services for stem cell scientists are used by leading pharmaceutical and biotechnology companies as well as top academic and government research institutions all around the globe.

Background image: induced pluripotent stem cells (iPSCs) stained for Tra-160 and NANOG (pluripotency markers), and with DAPI (nuclear stain).

Clinical Stem Cell Services

Developing cellular therapies requires strict adherence to manufacturing and regulatory standards that are different for each national regulatory agency. REPROCELL can help you through all stages of your regenerative medicine project.

Clinical iPSC Production Service

REPROCELL can provide you with clinical iPSCs for your therapeutic project, created with our state-of-the-art RNA reprogramming technology. You can test our clonal lines for suitability before scaling up to a GMP Master Cell Bank.

 Discover more

TC flask and pipette - 4x3

Clinical iMSC & MSC Production Service

Whatever the source of MSCs or derivatives thereof you need, REPROCELL can help you drive your next clinical MSC project to success and ensure compliancy with regulatory agencies.

 Discover more

Histocell lab

Clinical Stem Cell Services

Research Stem Cell Services

Footprint-free iPSC reprogramming and differentiation.

Donor recruitment

Donor Recruitment

With over 25 years of experience in the biobank sector, REPROCELL operates an extensive human tissue network. Through our clinical partnerships, we can access a diverse range of fresh clinical material from donors with a full medical and drug history.

Discover more

Target cell isolation

Target Cell Isolation

REPROCELL can recruit donors from a range of patient populations, collect viable biospecimens, and then prepare primary cell lines for you — e.g., Endothelial Progenitor Cells (EPCs), adult dermal and neonatal fibroblasts, and Urine-derived Progenitor Cells (UPCs).

Discover more

iPSC reprogramming

iPSC Reprogramming

At REPROCELL, you can gain access to the most rapid integration-free reprogramming method on the market: StemRNA™ 3rd Gen reprogramming technology. StemRNA™ is up to 50 times more efficient than any other non-integrative methodology on the market, allowing you to access the highest quality iPSCs for your research. 

Discover more

Expansion & characterization

Expansion & Characterization

REPROCELL has developed and characterized over 100 iPSC lines from a variety of human clinical samples, including both normal and diseased tissue. Our experience ensures that you will receive the best quality cell line and full information disclosure about its features and expected performance.

Discover more

Neuronal differentiation

Neuronal Differentiation

We launched our first commercial neurons, ReproNeuro, in 2012, and are now in possession of a wide range of iPSC differentiation capabilities. Currently, REPROCELL is using ReproNeuro technology to expand our range of capabilities even further — our most recent development being the introduction of dopaminergic and sensory neurons.

Discover more

Genome editing

StemEdit Gene Editing

At REPROCELL, we have collaborated with GenAhead Bio to provide StemEdit gene editing services. This novel approach to genome modification makes it possible to achieve otherwise challenging mutations.

Discover more

Research Stem Cell Services

REPROCELL Stemgent’s 3rd Generation RNA Reprogramming Technology

Our latest reprogramming technology, StemRNA™ 3rd Gen, provides the highest efficiency footprint-free reprogramming available to generate high-quality ready-to-use iPSCs.

Besides being available in kit form for stem cell scientists (the StemRNA™ 3rd Gen Reprogramming Kit, product #00-0076), this same proprietary reprogramming technology forms the basis of REPROCELL's global iPSC reprogramming service.

When combined with comprehensive REPROCELL know-how from our stem cell labs on four continents, StemRNA 3rd Gen RNA reprogramming technology provides our clients with a full range of iPSC services including:

StemRNA 3rd Gen Kit 00-0076 aspect-ratio-16x9

StemRNA™ 3rd Gen Reprogramming Kit (00-0076)

Our customers include pharmaceutical and biotechnology companies, as well as top academic and government research institutions from around the globe.

StemRNA 3rd Gen RNA reprogramming technology and iPSC usage can also be made available for various commercial applications with licenses available through REPROCELL Inc.

Stemgent Product Sub-Brands

Stemgent branded products available in the REPROCELL product catalog online.

mRNA Reprogramming Technology

StemRNA is a brand of Stemgent for our mRNA-based reprogramming technology and kits, and the cells derived from iPS cells generated using this technology. StemRNA reprogramming technology offers vector-free, rapid, high-efficiency reprogramming of fibroblasts and blood and urine cells to generate clinically relevant iPS cells ready for differentiation.

Small Molecules

Stemolecule is a brand of Stemgent for a series of small molecules that are reagents useful for stem cell reprogramming, maintenance, or differentiation. Most Stemolecules, such as Y27632 and CHIR99021, are enzyme inhibitors. Stemolecules are high-quality reagents sourced from suppliers that have been validated by REPROCELL for superior performance in stem cell applications.

Antibodies for Cell-Specific Pluripotency Markers

StemAB is a brand of Stemgent for our portfolio of antibodies targeted against stem cell-specific pluripotency markers. StemAB antibodies are validated for use in a variety of applications, including FACS and immunofluorescence microscopy staining. StemAB antibodies are useful for monitoring the quality of iPS cells and ES Cells after reprogramming or isolation.

Growth Factors & Cytokines

Stemfactor is a brand of Stemgent for a series of growth factors, cytokines, and other purified proteins that are reagents useful for stem cell reprogramming, maintenance, or differentiation. Stemfactors are high-quality reagents that have been validated by REPROCELL for superior performance in stem cell applications.

 REPROCELL Product Catalog

Gallery

Anti-TRA-1-60 staining of iPSCs

Anti-TRA-1-60 staining of iPSCs.

StemAb Nanog antibody

Anti-nanog staining of fibroblast derived iPSCs.

Tyrosine Hydroxylase/βIII-Tubulin staining of iPSC-derived dopaminergic neurons

iPSCs generated from urine-derived cells,  βIII-Tubulin/Nesting staining

The history of Stemgent

The Stemgent brand of REPROCELL has it origins in 2008 when the company was founded with offices in Cambridge, MA and San Diego, CA. The corporate business model was to commercialize research tools for induced pluripotent stem cell (iPSC) research, including reprogramming technologies and stem cell reagents. In 2014, Stemgent was acquired by REPROCELL, and in 2017, Stemgent moved to Beltsville, MD.

Stemgent’s reputation was built on cutting-edge mRNA-based iPSC reprogramming technology and a portfolio of stem cell–qualified reagents including small molecules (Stemolecule™) and protein factors (StemFactor™) to facilitate reprogramming and stem cell growth and maintenance.

Timeline

2024 – REPROCELL Stemgent launches iMSC iPSC-derived Mesenchymal Stem Cells.
2018 – REPROCELL Stemgent launches clinical iPSC services bring the power of the StemRNA technology to therapeutic applications.
2016 – Stemgent merges operations with Bioserve (Beltsville, MD) to become part of REPROCELL USA Inc.
2015 –  Stemgent introduces the StemRNA 3rd Gen Reprogramming Kit, the leading RNA technology for reprograming multiple cell types, such as fibroblasts and blood and urine derived cells.
2014 – Stemgent iPS cell business unit is acquired by REPROCELL company (Japan).
2010 – Stemgent held the first commercially available iPS training course at the National Institute of Health facility.
2009 – Stemgent is voted as one of the Top 25 up-and-coming biotechnology companies by a prominent global publishing organization.
2008 – Stemgent is founded, offering the first set of research tools focused on cellular reprogramming.

Speak to our experts
On the REPROCELL blog

Latest in Stem Cells

Current Landscape of FDA Stem Cell Approvals and Trials 2023-2025

Current Landscape of FDA Stem Cell Approvals and Trials 2023-2025

Discover the latest advancements and FDA approvals in stem cell therapies, including iPSC and MSC treatments, reshaping the 2023-2025 clinical landscape.

02 September 2025

Why Early Genetic Variant Detection in iPSC Cultures Is Critical for Safe and Regulatory-Compliant Cell Therapies

Why Early Genetic Variant Detection in iPSC Cultures Is Critical for Safe and Regulatory-Compliant Cell Therapies

Explore the crucial role of early genetic variant detection in iPSC cultures for ensuring safe, effective, and regulatory-compliant cell therapies. Learn about risk profiling and REPROCELL’s solutions.

01 August 2025

Able Biott Single-use Bioreactors Enhance the Development of Disease Models and Cell Therapy

Able Biott Single-use Bioreactors Enhance the Development of Disease Models and Cell Therapy

Discover how Able Biott single-use bioreactors enhance disease modeling and cell therapy development through scalable, efficient iPSC culture solutions.

03 July 2025

More in Stem Cells