Human Tissue Pharmacology

Preclinical and Drug Discovery CRO

REPROCELL Biopta’s human tissue technology predicts clinical success by using the closest possible model of drug behavior in humans.

Human tissue testing is a translational approach to drug discovery that bridges the gap between animal studies and clinical trials — increasing clinical success rates and adding commercial value to preclinical drug assets through proof of concept in patient-derived living tissues.

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Types of human tissue assay

This invaluable information allows you to make ‘go’ or ‘no-go’ decisions with greater confidence, based on human data generated in fresh biospecimens sourced from the target patient population or in bioengineered human tissues. Find out more about our human tissue assays.

Inflammatory Bowel Disease

Our IBD culture model assesses the anti-inflammatory properties of your lead compounds in explants from patients with ulcerative colitis or Crohn's disease.

Skin

Pro or anti-inflammatory properties of your test compound can be tested ex vivo using human intact fresh functional health or diseased skin.

Respiratory

Our respiratory assays allow the safety or efficacy of your test drug to be determined in human fresh intact lung tissues from healthy or diseased lungs.

Cardiovascular

Customized protocols that answer your specific questions about the effects of test drugs on human cardiac or vascular function using fresh intact blood vessels or cardiac muscle.

Species Comparison

Highlight potential species differences early in the drug development process and provide a bridge between animal and human datasets.

Genitourinary

An extensive range of assays in human genitourinary tissues including uterus, bladder, prostate, ureter and urethra.

Gastrointestinal Motility

Our state-of-the-art organ bath model is designed to investigate the impact of test compounds on gastrointestinal (GI) motility.

ADME/DMPK

Ussing chambers allow sensitive measurements of drug absorption, metabolism or ion channel function in human gastrointestinal tissues.

Assay Catalog screen-capture January 2025

Drug discovery assay catalog

REPROCELL Biopta is home to the world’s first and largest human fresh tissue assay catalog. In this digital platform, you can filter our assays by tissue type, endpoint, receptor, platform technology, drug type, and more.

Browse our full catalog

Alvetex® bioengineered 3D tissue services

Complementing our fresh tissue assays by accurately recreating human biology in bioengineered tissues.

Bioengineered 3D tissue models

ibdiscovery ibd intestine big data organ research

IBD model

IPF model

07AUG20 full thickness skin epidermis dermis microscopy histology

Skin model

Neurite model

Examples of our work

Our expertise in all areas of human tissue testing – including ethics, sourcing, handling, and fee-for-service experiments in human fresh tissue – allows us to act as your human tissue research department. See all our case studies.

IPM Case Study

Achieve regulatory approval

When IPM approached the regulators for approval of their HIV prevention ring, they requested additional data on uterine contractility. Find out how our studies in fresh human uterine tissue helped IPM gain approval.

Amgen Case Study

Avoid species differences

Read our case study on Amgen's publication, which highlights the useful comparisons that can be made between matched tissues from preclinical species and humans.

Roche Case Study

Eliminate clinical adverse effects

Adverse effects may go undetected during preclinical safety assessments and only become apparent during clinical trials. In most cases, such adverse effects in humans were not observed in animal models.

Bionorica Case Study

Evaluating spasmolytic effects of BNO 1095

REPROCELL supported Bionorica in advancing BNO 1095, a plant-based treatment for primary dysmenorrhea, through human tissue studies demonstrating its spasmolytic effects.

Why use human tissue in drug discovery?

Managing risks and saving money

Human fresh tissue can be used to manage risk and save money across the entire drug discovery pipeline.

How we use human tissue in drug discovery

The Use of Human Fresh Tissues in the Drug Discovery Pipeline

Demonstrating efficacy and safety

Human fresh tissue can be used in all phases of drug discovery programs, from target validation to clinical trouble shooting.

Drug discovery phases

Our human tissue platform technologies

At REPROCELL, we offer a unique range of experimental techniques for translating data from preclinical species to humans. Explore our platform technologies.

Tissue Baths and Wire Myographs

Explore nerve-muscle interactions and the contractility of smooth, cardiac, or skeletal muscles.

Ussing Chambers

Investigate the electrochemical properties of membranes and epithelia.

Ex vivo Tissue Culture

Measure a range of functional endpoints including cytokine production and gene expression.

Bioengineered 3D Tissue Models

Interrogate the mechanisms of action of your compound in three dimensions with confidence.

Join our human tissue supplier network

We are investing in our tissue network to meet the growing safety and efficacy requirements of drug development programs and medicine regulators around the globe.

Help us bring new medicines to the clinic

Clinical Laboratory Services and Precision Medicine

Laboratory services specialising in human biospecimens and AI-driven data analysis.

Clinical Laboratory Services

We coordinate, process, test, and analyze a range of fresh human biospecimens to meet the demands of your clinical research.

See our range of GCLP services

REPROCELL Sara in stem cell clinical lab

Pharmacology-AI

Machine learning platform for rapid identification of the features driving variation in patient outcomes — streamlining the development of effective patient stratification strategies.

Learn how AI can reveal new insights from your data

Contact our experts

Preclinical & Drug Discovery CRO

Drug Discovery Assay Catalog

Human Tissue Assays

Inflammatory Bowel Disease
Skin Disease
Respiratory
ADME DMPK
Species Comparison
Genitourinary
Gastrointestinal Motility
Cardiovascular

Bioengineered 3D Tissue Models

IBD Model
IPF Model
Skin Model
Neurite Outgrowth Model

Platform Technologies

Tissue Baths and Wire Myographs
Ussing Chambers
Ex vivo Tissue Culture
Bioengineered 3D Tissue Models

Why Human Tissue?

The Use of Human Fresh Tissues in the Drug Discovery Pipeline
Drug Discovery Phases
Human Tissue Supplier Network

Clinical Laboratory Services

Central Laboratory Services
Biomarker Discovery and Analytical Services
Gene Editing Services
Precision Medicine Services

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