For Preclinical Drug Developers

 

Preclinical and Drug Discovery CRO

REPROCELL Biopta’s human tissue technology predicts clinical success by using the closest possible model of drug behavior in humans.

Human tissue testing is a translational approach to drug discovery that bridges the gap between animal studies and clinical trials — increasing clinical success rates and adding commercial value to preclinical drug assets through proof of concept in patient-derived living tissues.

Which drug discovery challenges do you face?

Are you seeking proof of concept for your novel drug therapy?

Demonstrate human efficacy and safety in human living tissues, capturing real-world patient data.

Explore our range of human fresh tissue assays.

Are you managing a discovery pipeline in biotech or pharma?

Generate commercial value and de-risk your preclinical assets through human data.

View our case studies on human fresh tissue assays.

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Troubleshooting clinical safety

REPROCELL has expertise in human fresh tissue safety pharmacology and cross-species comparative studies – to GLP if required.

We can help by generating data in human functional tissues.

Types of human tissue assay

This invaluable information allows you to make ‘go’ or ‘no-go’ decisions with greater confidence, based on human data generated in fresh biospecimens sourced from the target patient population or in bioengineered human tissues. Find out more about our human tissue assays.

Assay Catalog screen-capture January 2025

Drug discovery assay catalog

REPROCELL Biopta is home to the world’s first and largest human fresh tissue assay catalog. In this digital platform, you can filter our assays by tissue type, endpoint, receptor, platform technology, drug type, and more.

From Target to Treatment Accelerating Drug Discovery with Human-Relevant Insights

By combining advanced in vitro systems, patient-derived tissues, and data-rich analysis at every stage, we help bridge the gap between discovery and the clinic, enabling more confident decision-making and increasing the likelihood of clinical success.

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Alvetex® bioengineered 3D tissue services

Complementing our fresh tissue assays by accurately recreating human biology in bioengineered tissues.

 Bioengineered 3D tissue models

Examples of our work

Our expertise in all areas of human tissue testing — including ethics, sourcing, handling, and fee-for-service experiments in human fresh tissue — allows us to act as your human tissue research department. See all our case studies.

IPM Case Study

Lindsey and Amna at microscopes

Achieve regulatory approval

When IPM approached the regulators for approval of their HIV prevention ring, they requested additional data on uterine contractility. Find out how our studies in fresh human uterine tissue helped IPM gain approval.

Amgen Case Study

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Avoid species differences

Read our case study on Amgen's publication, which highlights the useful comparisons that can be made between matched tissues from preclinical species and humans.

Roche Case Study

Pipetting at wire myographs

Eliminate clinical adverse effects

Adverse effects may go undetected during preclinical safety assessments and only become apparent during clinical trials. In most cases, such adverse effects in humans were not observed in animal models.

Bionorica Case Study

Michael at wire myographs

Evaluating spasmolytic effects of BNO 1095

REPROCELL supported Bionorica in advancing BNO 1095, a plant-based treatment for primary dysmenorrhea, through human tissue studies demonstrating its spasmolytic effects.

Why use human tissue in drug discovery? 

Managing risks and saving money

Human fresh tissue can be used to manage risk and save money across the entire drug discovery pipeline.

How we use human tissue in drug discovery

The Use of Human Fresh Tissues in the Drug Discovery Pipeline

Demonstrating efficacy and safety

Human fresh tissue can be used in all phases of drug discovery programs, from target validation to clinical trouble shooting.

Drug discovery phases

Drug Discovery Phases

Our human tissue platform technologies

At REPROCELL, we offer a unique range of experimental techniques for translating data from preclinical species to humans. Explore our platform technologies.

Michael at wire myographs

Tissue Baths and Wire Myographs

Explore nerve-muscle interactions and the contractility of smooth, cardiac, or skeletal muscles.

Ussing chamber setup

Ussing Chambers

Investigate the electrochemical properties of membranes and epithelia.

Pipetting media in safety cabinet

Ex vivo Tissue Culture

Measure a range of functional endpoints including cytokine production and gene expression.

Alvetex 12 well plate

Bioengineered 3D Tissue Models

Interrogate the mechanisms of action of your compound in three dimensions with confidence.

Join our human tissue supplier network

We are investing in our tissue network to meet the growing safety and efficacy requirements of drug development programs and medicine regulators around the globe.

Help us bring new medicines to the clinic

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Clinical Laboratory Services and Precision Medicine

Laboratory services specialising in human biospecimens and AI-driven data analysis.

Clinical Laboratory Services

We coordinate, process, test, and analyze a range of fresh human biospecimens to meet the demands of your clinical research.

See our range of GCLP services

REPROCELL Sara in stem cell clinical lab

Pharmacology-AI

Machine learning platform for rapid identification of the features driving variation in patient outcomes — streamlining the development of effective patient stratification strategies.

Learn how AI can reveal new insights from your data

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Contact our experts