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Human Tissue Pharmacology

 

Preclinical and Drug Discovery CRO

REPROCELL Biopta’s human tissue technology predicts clinical success by using the closest possible model of drug behavior in humans.

Human tissue testing is a translational approach to drug discovery that bridges the gap between animal studies and clinical trials — increasing clinical success rates and adding commercial value to preclinical drug assets through proof of concept in patient-derived living tissues.

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REPROCELL Biopta® — the human tissue experts

Trusted by top Pharma

Drug discovery assay catalog

REPROCELL Biopta is home to the world’s first and largest human fresh tissue assay catalog. In this digital platform, you can filter our assays by tissue type, endpoint, receptor, platform technology, drug type, and more.

Browse our full catalog

Drug Discovery Assay Catalog
CRISPR/Cas9 gene editing DNA

Alvetex® bioengineered 3D tissue services

Complementing our fresh tissue assays by accurately recreating human biology in bioengineered tissues.

 Bioengineered 3D tissue models

Human tissue assay types

This invaluable information allows you to make ‘go’ or ‘no-go’ decisions with greater confidence, based on human data generated in fresh biospecimens sourced from the target patient population or in bioengineered human tissues.

About our human tissue assays

Examples of our work

Our expertise in all areas of human tissue testing – including ethics, sourcing, handling, and fee-for-service experiments in human fresh tissue – allows us to act as your human tissue research department.

IPM Case Study

Lindsey and Amna at microscopes

Achieve regulatory approval

When IPM approached the regulators for approval of their HIV prevention ring, they requested additional data on uterine contractility. Find out how our studies in fresh human uterine tissue helped IPM gain approval.

Amgen Case Study

skin biopsies

Avoid species differences

Read our case study on Amgen's publication, which highlights the useful comparisons that can be made between matched tissues from preclinical species and humans.

Roche Case Study

Pipetting at wire myographs

Eliminate clinical adverse effects

Adverse effects may go undetected during preclinical safety assessments and only become apparent during clinical trials. In most cases, such adverse effects in humans were not observed in animal models.

All case studies

Why use human tissue?

Managing risks and saving money in drug discovery

Human fresh tissue can be used to manage risk and save money across the entire drug discovery pipeline.

How we use human tissue in drug discovery

The Use of Human Fresh Tissues in the Drug Discovery Pipeline

Demonstrating efficacy and safety at every phase of drug discovery

Human fresh tissue can be used in all phases of drug discovery programs, from target validation to clinical trouble shooting.

Drug discovery phases

Drug Discovery Phases

Our human tissue platform technologies

At REPROCELL, we offer a unique range of experimental techniques for translating data from preclinical species to humans.

Michael at wire myographs

Tissue Baths and Wire Myographs

Explore nerve-muscle interactions and the contractility of smooth, cardiac, or skeletal muscles.

Ussing chamber setup

Ussing Chambers

Investigate the electrochemical properties of membranes and epithelia.

Pipetting media in safety cabinet

Ex vivo Tissue Culture

Measure a range of functional endpoints including cytokine production and gene expression.

Alvetex 12 well plate

Bioengineered 3D Tissue Models

Interrogate the mechanisms of action of your compound in three dimensions with confidence.

Explore our platform technologies

Join our human tissue supplier network

We are investing in our tissue network to meet the growing safety and efficacy requirements of drug development programs and medicine regulators around the globe.

Get involved

surgery-stitching

Contact our experts