Drug Discovery Assay Catalog
REPROCELL Biopta is home to the world's first and largest human fresh tissue assay catalog. In this digital platform, you can filter our assays by tissue type, endpoint, receptor, platform technology, drug type, and more.
IBD assays
Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn’s disease, have become a key focus for Pharma in recent years. Our scientists have extensive experience with efficacy, contractility, safety, ex vivo cultures, and ADME assays using intestinal tissue. We can access tissues from patients suffering from IBD, including Crohn’s disease and ulcerative colitis to investigate drug effects on intestinal permeability and inflammation.
Skin disease assays
Skin diseases represent a major health concern in the world today. Psoriasis affects more than 100 million people worldwide and is responsible for twice the disability burden caused by acute hepatitis C. We provide translational products and services to develop new therapies for serious skin diseases, including psoriasis, acne, and atopic dermatitis. Several inflammatory skin disease models are available to suit your research needs and budget, including patient biopsies, induced models, and 3D models.
Respiratory assays
Respiratory diseases are some of the most common medical conditions in the world. Chronic obstructive pulmonary disease (COPD) accounts for 5% of global deaths annually, while asthma is the most common non-communicable disease in children. We offer an extensive range of assays in fresh human lung tissue from non-transplantable lungs or surgical residual tissues, including precision-cut lung slices (PCLS), pulmonary arteries, airway contractility, and lung parenchymal culture.
Cardiovascular assays
As a leading cause of death in the developed world, Cardiovascular disease (CVD) continues to be a major focus of drug development. However, even if you are not a CVD researcher, you may be interested in negating any off-target cardiovascular effects of your test articles. We offer assays in numerous cardiovascular tissues including cardiac muscle, arteries, and veins.
Species comparison assays
If you want to translate your data from animal models, we can directly compare human and animal data in our ex vivo models. Our species comparison assays provide an improved understanding of species differences in response to your test article and are commonly used to troubleshoot clinical adverse effects in respiratory, cardiovascular, genitourinary, and ADME/DMPK studies.
Genitourinary assays
Genitourinary disorders include congenital anomalies, infectious diseases, trauma, or conditions that involve the urinary structure or function. Our scientists have extensive experience assessing contractile and relaxation responses in these tissues, including the uterus, ureter, urethra, prostate, and bladder.
Gastrointestinal motility assays
A change in gastrointestinal (GI) motility can result in a spectrum of symptoms, including heartburn, diarrhea, and gastroparesis. We can investigate the effect of your article on GI motility in a range of human tissues, including the stomach, intestines and lower esophageal sphincter. Determine the therapeutic potential of your compound, or investigate adverse clinical effects using our fresh ex vivo assays.
ADME/DMPK assays
Accurately predicting the oral bioavailability of your test articles is key to clinical success. Our ADME studies use human tissues to estimate drug permeability, metabolism, or ion channel function ex vivo — giving you the most accurate prediction of oral bioavailability before clinical trial. With our Ussing chamber system, we can measure the effects of your test article on gastrointestinal permeability, gastrointestinal metabolism, and ion channel function.
Alvetex® bioengineered 3D tissue services
REPROCELL's 3D bioengineered human tissues, produced using Alvetex®, complement our fresh tissue assays by accurately recapitulating human biology in longer duration experiments, allowing investigations into mechanisms that are key to many drug targets including fibrosis, wound healing and epithelial barrier disruption.
Our human tissue models are also useful for testing other substances including chemicals, consumer products, cosmetics and pollutants.
