Lower Esophageal Sphincter Motility Assays 

The primary function of the lower esophageal sphincter (LES) is to allow food transit from the esophagus into the stomach. An incompetent LES can lead to Gastroesophageal reflux disease, increasing the risk for metaplasia and esophageal adenocarcinoma.

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Relaxation in Human Lower Esophageal Sphincter

This assay determines whether test articles affect the function of the lower esophageal sphincter (LES) muscle strips precontracted with Carbachol and using Isoprenaline to produce maximum relaxation.

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Contraction in human Lower Esophageal Sphincter

This assay determines whether test articles affect the function of the lower esophageal sphincter (LES) muscle strips with the TGR5 receptor as the target.