Species Comparison – Cardiovascular Assays
Many drugs have been shown to have a direct effect on cardiac function, but cardiac safety data generated in animals do not always mimic the human drug response. Our scientists can provide species comparison assays to determine whether your cardiac safety data will translate to humans. Several of our clients have used these studies to troubleshoot clinical adverse effects. For example, Amgen compared the vasodilation effects of their test article in canine and human blood vessels after clinical trial participants started experiencing headaches. They found that the drug caused significant vasodilation ex vivo, which they were able to reverse using an adenosine receptor agonist.
The 5-HT (serotonin) pathway is more prominent in the coronary artery function of humans than in canine tissues.