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5-HT Assays

If you are looking to improve the translatability of your drug discovery research, human tissue testing allows you to look at human data before testing your compound in the clinic. It can even be used to compare drug responses between animals and humans to investigate off-target drug effects on cardiovascular tissues. At REPROCELL, our scientists can test the effects of your compound on human blood vessels. You can find examples of our work listed below.

Vasoconstriction in human saphenous vein (5-HT receptor)
This assay assesses whether test articles cause vasoconstriction in human saphenous vein with sumatriptan as a reference compound.

Contractile force in electrically stimulated human ventricular trabeculae muscle (5-HT receptor)
This assay assesses whether test compounds cause an increase in contractile force in electrically stimulated human ventricular muscle with 5-HT as a reference compound.

Contractile force in electrically stimulated human atrial pectinate muscle (5-HT receptor)
This assay assesses whether test compounds cause an increase in contractile force in electrically stimulated human atrial muscle with 5-HT as a reference compound.

Vasoconstriction in human subcutaneous resistance arteries (5-HT receptor)
This assay assesses whether test articles cause vasoconstriction in human subcutaneous resistance arteries, with 5-HT as a reference compound.

Vasoconstriction in human coronary arteries (5-HT receptor – 5-HT)
This assay assesses whether test articles cause vasoconstriction in human coronary arteries with 5-HT as a reference compound. Coronary arteries supply blood to the myocardium.

Vasoconstriction in human coronary arteries (5-HT receptor – Sumatriptan)
This assay assesses whether test articles cause vasoconstriction in human coronary arteries with sumatriptan as a reference compound.

Vasoconstriction in denuded human coronary arteries (5-HT receptor)
This assay assesses whether test articles cause vasoconstriction in denuded human coronary arteries with 5-HT as a reference compound.