Phenotypic Skin Disease Models
For these models, a disease-like phenotype is simulated in healthy human skin biopsies sourced from cosmetic surgery procedures. Proprietary cocktails are used to stimulate disease pathways in these tissue samples, resulting in the upregulation of disease-relevant inflammatory mediators, such as Th17/IL-17 or IL-23 pathways. Once the disease phenotype has been achieved, your test compounds are added followed by an assessment of their anti-inflammatory effects.