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Gastrointestinal Metabolism Assays

In addition to our permeability model, we can also estimate gastrointestinal metabolism in our Ussing chamber system. By choosing to predict drug metabolism in living human tissues you can negate the metabolic and species differences presented by Caco-2 and animal models.

  • Up to 12 isolated tissue preparations per donor
  • Metabolism due to both Phase 1 and Phase 2 enzymes can be measured
  • Multiple drugs can be investigated in each experiment
  • Provides the closest method to testing your drug in the clinic

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Image: One of our scientists operating an Ussing chamber in our Glasgow laboratory.

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Healthy GI metabolism model

This assay uses gastrointestinal biopsies to investigate the effects of your test article on Phase1 and Phase 2 metabolic enzymes.