Bladder Contraction and Relaxation

The primary function of the bladder is to store urine before micturition. Alterations to the contraction and relaxation of the bladder can affect filling and emptying, causing disorders such as incontinence and bladder hypertrophy. We can assess the effect of your test article on bladder smooth muscle tone using fresh functional bladder tissues.

  • Both EC/IC50 and pA2 can be determined
  • Electrical field stimulation (EFS) can be used to activate nerves that cause bladder contraction
  • Reference compounds available include carbachol, isoproterenol, and retigabine

Bladder tissue 2

Image: Example of fresh bladder tissue used in our bladder contractility studies.

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Isoproterenol model

Discover whether your test article affects bladder relaxation via adrenoceptors, with isoproterenol as a reference compound.

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Carbachol model

Discover whether your test article affects bladder contraction via muscarinic receptors, with carbachol as a reference compound.

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Muscarinic and β-adrenergic receptor model

Discover whether your test article affects bladder contraction induced by electrical field stimulation.