Urethra Contraction

The urethra plays a crucial role in the excretion of urine and semen. Any alterations in its structure or function, such as those caused by prostate hypertrophy, can significantly affect this process. At REPROCELL, we offer a comprehensive range of human-based services to evaluate the effects of your test compound on the contraction or relaxation of the human urethra. 

Our specialized assays allow for the assessment of urethral function through protocols such as passive tension experiments, relaxation of pre-contracted muscle strips, and nerve activation using electrical field stimulation (EFS). We utilize precisely isolated circular urethral tissue samples, fully separated from prostate tissue, which are attached to highly sensitive transducers to measure changes in muscle tension. This enables us to conduct functional tests to determine the contractile responses of the urethra, bladder, and prostate to test drugs. 

Our advanced techniques include the use of tissue baths for measuring the force of urethral contractions in isolated urethral rings. These methods ensure accurate, detailed insights into the pharmacological effects of your test compound on urethral smooth muscle function. 

All tissue samples are ethically sourced through transplant networks or obtained as surgical residual material, ensuring high-quality biological specimens for every study.