Skin Disease Assays
Our human fresh skin disease assays provide the most clinically relevant in vitro assessments of new therapies of any CRO. The pro or anti-inflammatory properties of your test compound can be tested ex vivo using human intact fresh functional skin. Skin tissues are received either as biopsies obtained from patients with psoriasis or atopic dermatitis or for our higher throughput models, using human fresh skin induced to a disease-relevant inflammatory phenotype, such as our Th17 phenotypic model.
Histological images. Left: Alvetex™ 3D human skin model. Right: real human skin.
Up to 20 test conditions can be assessed using skin from a single donor allowing for comparatively high throughput and quick turnaround, and your test article can be added to the culture media or applied topically to allow assessment of different formulations. Any resultant changes in inflammatory mediators can be measured via multiplex ELISA/Luminex or via changes in histology or gene expression, using approaches such as RT-PCR, RNA-Seq, or even single-cell RNA sequencing.