Gastrointestinal Permeability Assays

Our permeability studies use human gastrointestinal (GI) tissues which have a phenotypically accurate balance of drug-metabolizing enzymes and transporters. A typical experiment involves the application of a drug to the apical surface of the tissue, followed by periodic sampling of the Ussing chambers to measure the passage of drugs and any metabolites.

  • Between 6-12 biopsies available per donor
  • Healthy and diseased (inflammatory bowel disease) tissues can be used
  • Three reference control compounds compared to test article
  • Provides the closest method to testing your drug in the clinic
  • Option to conduct studies in accordance with GLP

Ussing chamber close up
Close-up of one of our scientists operating an Ussing chamber in our Glasgow laboratory.

 

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IBD permeability model

This model uses gut biopsies from IBD donors to assess the gastrointestinal permeability of your test articles.

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Heathy GI permeability model

This model uses gut biopsies from healthy donors to assess the gastrointestinal permeability of your test articles.