Gastrointestinal Permeability Assays

Our permeability studies use human gastrointestinal (GI) tissues which have a phenotypically accurate balance of drug-metabolizing enzymes and transporters. A typical experiment involves the application of a drug to the apical surface of the tissue, followed by periodic sampling of the Ussing chambers to measure the passage of drugs and any metabolites.

  • Between 6-12 biopsies available per donor
  • Healthy and diseased (inflammatory bowel disease) tissues can be used
  • Three reference control compounds compared to test article
  • Provides the closest method to testing your drug in the clinic
  • Option to conduct studies in accordance with GLP

Ussing chamber close up
Close-up of one of our scientists operating an Ussing chamber in our Glasgow laboratory.

IBD permeability model
This model uses gut biopsies from IBD donors to assess the gastrointestinal permeability of your test articles.

Heathy GI permeability model
This model uses gut biopsies from healthy donors to assess the gastrointestinal permeability of your test articles.