Our permeability studies use human gastrointestinal (GI) tissues which have a phenotypically accurate balance of drug-metabolizing enzymes and transporters. A typical experiment involves the application of a drug to the apical surface of the tissue, followed by periodic sampling of the Ussing chambers to measure the passage of drugs and any metabolites.
Between 6-12 biopsies available per donor
Healthy and diseased (inflammatory bowel disease) tissues can be used
Three reference control compounds compared to test article
Provides the closest method to testing your drug in the clinic
Option to conduct studies in accordance with GLP
Close-up of one of our scientists operating an Ussing chamber in our Glasgow laboratory.
IBD permeability model This model uses gut biopsies from IBD donors to assess the gastrointestinal permeability of your test articles.
Heathy GI permeability model This model uses gut biopsies from healthy donors to assess the gastrointestinal permeability of your test articles.
