Species Comparison – Respiratory Assays
Approximately one-third of all respiratory abnormalities during human clinical trials can be attributed to unforeseen drug-mediated changes in airway resistance. Even guinea pigs, the most commonly used animal model of respiratory function, fail to replicate all human drug responses.
Taken together, these findings suggest that the prediction of human bronchoconstriction could be vastly improved by performing an early species comparison study to explore the relevance of the animal model to humans. At REPROCELL, our scientists can compare the effects of your test compounds on the constriction or relaxation of animal and human airways (bronchi). We can also assess species differences in airway inflammation, using our ex vivo precision-cut lung slice (PCLS) and parenchymal explant models.
|Species||pD2 acetylcholine||pD2 histamine|
|Human||4.56||5.31 ± 0.27|
|Guinea pig||5.89||5.31 ± 0.72|