Intestinal Motility Assays

Changes in intestinal motility can lead to irritable bowel syndrome, diarrhea, and Ulcerative Colitis. In our electrical field stimulated organ bath model, we can measure changes in gastrointestinal motility in response to your test compound. The specific results that will be provided are the effects of increasing concentrations of test articles on the contractile state of isolated human intestinal tissue.

  • Galantamine and Meptazinol are available as reference compounds
  • Suggested testing on your compound is in duplicate at 6 concentrations
  • Responses shall be expressed as % change from baseline EFS response

100_1122-1

Image: An example of healthy intestinal tissue used in our gut motility studies.

icon-pdd-cro
Gut motility (ACh esterase) model

This model uses electrically stimulated tissues to assess whether your test article affects GI motility compared with Galantamine.

icon-pdd-cro
Gut motility (opioid receptor) model

This model uses electrically stimulated tissues to assess whether your test article affects small or large intestine motility.