- Preclinical & Drug Discovery CRO
- Drug Discovery Assay Catalog
Drug Discovery Assay Catalog
REPROCELL has investigated the safety and efficacy of thousands of compounds for its Pharma clients since 2002.
This human tissue assay catalog contains only a small number of our experimental endpoints, that we can list as a public example of our work. Here you can browse some of our real examples of ex vivo pharmacological data – with over 100 drug targets, tissue types, and compounds.
REPROCELL Biopta™ – the human tissue experts
If you have any inquiries about our drug discovery assays, or to discuss your particular contract reasearch project needs, please contact us.
Total assays available:
Vasoconstriction in Human Coronary Arteries (5-HT Receptor – 5-HT)
Reference number: B003
| Assay type: | Blood Vessels |
| Tissue: | Human Coronary Artery (Healthy) |
| Target: | 5-HT receptor |
| Control Compound: | 5-HT |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasoconstriction |
Vasoconstriction in Human Coronary Arteries (Opioid and Opioid-Like Receptors)
Reference number: B004
| Assay type: | Blood Vessels |
| Tissue: | Human Coronary Artery (Healthy) |
| Target: | Opioid & opioid-like receptors |
| Control Compound: | Mephedrone |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasoconstriction |
Vasoconstriction in Human Coronary Arteries (Angiotensin Receptor)
Reference number: B007
| Assay type: | Blood Vessels |
| Tissue: | Human Coronary Artery (Healthy) |
| Target: | Angiotensin receptor |
| Control Compound: | Angiotensin II |
| Study Type: | Organ bath |
| Functional Endpoint: | Vasoconstriction |
Vasoconstriction in Human Coronary Arteries (Vasopressin & Oxytocin Receptors)
Reference number: B008
| Assay type: | Blood Vessels |
| Tissue: | Human Coronary Artery (Healthy) |
| Target: | Vasopressin & oxytocin receptors |
| Control Compound: | 8-arginine vasopressin |
| Study Type: | Organ bath |
| Functional Endpoint: | Vasoconstriction |
Vasodilatation in Human Chorionic Plate Arteries (PDE5)
Reference number: B009
| Assay type: | Blood Vessels |
| Tissue: | Human Chorionic Plate Arteries (Pre-Eclamptic) |
| Target: | PDE5 |
| Control Compound: | Sildenafil |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in Human Chorionic Plate Arteries (Bradykinin receptor)
Reference number: B010
| Assay type: | Blood Vessels |
| Tissue: | Human Chorionic Plate Arteries (Healthy) |
| Target: | Bradykinin receptor |
| Control Compound: | Bradykinin |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in Human Pre-Eclamptic Chorionic Plate Arteries (PDE5)
Reference number: B011
| Assay type: | Blood Vessels |
| Tissue: | Human Chorionic Plate Arteries (Pre-Eclamptic) |
| Target: | PDE5 |
| Control Compound: | Sildenafil |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in Human Pre-Eclamptic Chorionic Plate Arteries (Bradykinin Receptor)
Reference number: B012
| Assay type: | Blood Vessels |
| Tissue: | Human Chorionic Plate Arteries (Pre-Eclamptic) |
| Target: | Bradykinin receptor |
| Control Compound: | Bradykinin |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in Human Subcutaneous Resistance Arteries (Acetylcholine Receptor)
Reference number: B016
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | Acetylcholine receptor |
| Control Compound: | Acetylcholine |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in Human Subcutaneous Resistance Arteries (Vasopressin & Oxytocin Receptors)
Reference number: B017
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | Vasopressin & oxytocin receptors |
| Control Compound: | Desmopressin |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in Human Subcutaneous Resistance Arteries (Nitric Oxide Donor)
Reference number: B019
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | Nitric oxide donor |
| Control Compound: | SNP |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasoconstriction in Human Subcutaneous Resistance Arteries (Adrenoceptor)
Reference number: B020
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Phenylephrine |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasoconstriction in Human Subcutaneous Resistance Arteries (Prostanoid Receptor)
Reference number: B021
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | Prostanoid receptor |
| Control Compound: | U46619 |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasoconstriction |
Vasodilatation in Ischaemic Human Subcutaneous Resistance Arteries (Bradykinin Receptor)
Reference number: B022
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Ischaemic) |
| Target: | Bradykinin receptor |
| Control Compound: | Bradykinin |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasoconstriction in Human Saphenous Vein (5-HT Receptor)
Reference number: B023
| Assay type: | Blood Vessels |
| Tissue: | Human Saphenous Vein (Healthy) |
| Target: | 5-HT receptor |
| Control Compound: | Sumatriptan |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasoconstriction |
Vasoconstriction in Human Coronary Arteries (5-HT Receptor – Sumatriptan)
Reference number: B028
| Assay type: | Blood Vessels |
| Tissue: | Human Coronary Artery (Healthy) |
| Target: | 5-HT receptor |
| Control Compound: | Sumatriptan |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasoconstriction |
Vasoconstriction in Denuded Human Coronary Arteries (5-HT Receptor)
Reference number: B030
| Assay type: | Blood Vessels |
| Tissue: | Human Coronary Artery (Healthy – Denuded) |
| Target: | 5-HT receptor |
| Control Compound: | 5-HT |
| Study Type: | Organ bath |
| Functional Endpoint: | Vasoconstriction |
Vasodilatation in Human Subcutaneous Resistance Arteries (PDE3 Receptor)
Reference number: B034
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | PDE3 |
| Control Compound: | Milrinone |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in Human Subcutaneous Resistance Arteries (Bradykinin Receptor)
Reference number: B035
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | Bradykinin receptor |
| Control Compound: | Bradykinin |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasoconstriction in Atherosclerotic Human Subcutaneous Resistance Arteries (Angiotensin Receptor)
Reference number: B037
| Assay type: | Blood Vessels |
| Tissue: | Human Resistance Artery (Atherosclerotic) |
| Target: | Angiotensin receptor |
| Control Compound: | PDA-angiotensin 1 |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasoconstriction |
Vasodilatation in Ischaemic Human Subcutaneous Resistance Arteries (Nitric Oxide Donor)
Reference number: B038
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Ischaemic) |
| Target: | Nitric oxide donor |
| Control Compound: | SNP |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in Human Skeletal Muscle Arteries (Acetycholine Receptor)
Reference number: B039
| Assay type: | Blood Vessels |
| Tissue: | Human Skeletal Muscle Artery (Healthy) |
| Target: | Acetylcholine receptor |
| Control Compound: | Acetylcholine |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in Human Skeletal Muscle Arteries (Nitric Oxide Donor)
Reference number: B040
| Assay type: | Blood Vessels |
| Tissue: | Human Skeletal Muscle Artery (Healthy) |
| Target: | Nitric oxide donor |
| Control Compound: | SNP |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Contractile Force in Electrically Stimulated Human Atrial Pectinate Muscle (Adrenoceptors – Isoprenaline)
Reference number: B043
| Assay type: | Cardiac Muscle |
| Tissue: | Human Atrial Pectinate Muscle (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Isoprenaline |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractility |
Contractile Force in Electrically Stimulated Human Ventricular Trabeculae Muscle (5-HT Receptor)
Reference number: B047
| Assay type: | Cardiac Muscle |
| Tissue: | Human Ventricular Trabeculae Muscle (Healthy) |
| Target: | 5-HT receptor |
| Control Compound: | 5-HT |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractility |
Contractile Force in Electrically Stimulated Human Atrial Pectinate Muscle (5-HT Receptor)
Reference number: B048
| Assay type: | Cardiac Muscle |
| Tissue: | Human Atrial Pectinate Muscle (Healthy) |
| Target: | 5-HT receptor |
| Control Compound: | 5-HT |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractility |
Contractile Force in Electrically Stimulated Human Atrial Pectinate Muscle (Adrenoceptors – Salbutamol)
Reference number: B049
| Assay type: | Cardiac Muscle |
| Tissue: | Human Atrial Pectinate Muscle (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Salbutamol |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractility |
Contractile Force in Electrically Stimulated Human Atrial Pectinate Muscle (PDE3 Receptor)
Reference number: B050
| Assay type: | Cardiac Muscle |
| Tissue: | Human Atrial Pectinate Muscle (Healthy) |
| Target: | PDE3 |
| Control Compound: | Milrinone |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractility |
Bronchodilatation in Secondary Healthy Human Airways (Adrenoceptor – Isoprenaline)
Reference number: B052
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Isoprenaline |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchoconstriction in Secondary Asthmatic Human Airways (Acetylcholine Receptor)
Reference number: B053
| Assay type: | Respiratory |
| Tissue: | Human Secondary Airways (Asthmatic) |
| Target: | Acetylcholine receptor |
| Control Compound: | Carbachol |
| Study Type: | Organ bath |
| Functional Endpoint: | Bronchoconstriction |
Bronchodilatation in Secondary Asthmatic Human Airways (Adrenoceptor)
Reference number: B054
| Assay type: | Respiratory |
| Tissue: | Human Secondary Airways (Asthmatic) |
| Target: | Adrenoceptor |
| Control Compound: | Salbutamol |
| Study Type: | Organ bath |
| Functional Endpoint: | Bronchodilatation |
Bronchoconstriction in Tertiary or Lower Healthy Human Airways (Prostanoid Receptor)
Reference number: B055
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Healthy) |
| Target: | Prostanoid receptor |
| Control Compound: | U46619 |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchoconstriction |
Bronchodilatation in Tertiary or Lower Healthy Human Airways (Adrenoceptor – Salbutamol)
Reference number: B056
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Salbutamol |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchoconstriction in Tertiary or Lower Healthy Human Airways (Acetylcholine Receptor)
Reference number: B057
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Healthy) |
| Target: | Acetylcholine receptor |
| Control Compound: | Acetylcholine |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchoconstriction |
Bronchodilatation in Tertiary or Lower Healthy Human Airways (Adrenoceptor – Isoprenaline)
Reference number: B058
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Isoprenaline |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchodilatation in Tertiary or Lower Airways COPD (Adrenoceptor)
Reference number: B059
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (COPD) |
| Target: | Adrenoceptor |
| Control Compound: | Isoprenaline |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchoconstriction in Denuded Secondary Healthy Human Airways (Acetylcholine Receptor)
Reference number: B060
| Assay type: | Respiratory |
| Tissue: | Human Secondary Airways (Healthy – Denuded) |
| Target: | Acetylcholine receptor |
| Control Compound: | Carbachol |
| Study Type: | Organ bath |
| Functional Endpoint: | Bronchoconstriction |
Bronchoconstriction in Denuded Secondary Healthy Human Airways (Histamine Receptor)
Reference number: B061
| Assay type: | Respiratory |
| Tissue: | Human Secondary Airways (Healthy – Denuded) |
| Target: | Histamine receptor |
| Control Compound: | Histamine |
| Study Type: | Organ bath |
| Functional Endpoint: | Bronchoconstriction |
Bronchodilatation in Tertiary or Lower Human Airways (Adrenoceptors – Formoterol)
Reference number: B065
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Formoterol |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchodilatation in Tertiary or Lower Human Airways (Adrenoceptors – Salbutamol)
Reference number: B066
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Healthy) |
| Target: | |
| Control Compound: | Salbutamol |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchodilatation in Tertiary or Lower Asthmatic Human Airways (Adrenoceptor – Formoterol)
Reference number: B067
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Asthmatic) |
| Target: | Adrenoceptor |
| Control Compound: | Formoterol |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchodilatation in Tertiary or Lower Asthmatic Human Airways (Adrenoceptor – Salbutamol)
Reference number: B068
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Asthmatic) |
| Target: | Adrenoceptor |
| Control Compound: | Salbutamol |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchodilatation in Tertiary or Lower Asthmatic Human Airways (Adrenoceptor – Salmeterol)
Reference number: B069
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Asthmatic) |
| Target: | Adrenoceptor |
| Control Compound: | Salmeterol |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Relaxation in Human Bladder (Adrenoceptor – Isoproterenol)
Reference number: B070
| Assay type: | GU |
| Tissue: | Human Bladder (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Isoproterenol |
| Study Type: | Organ bath |
| Functional Endpoint: | Relaxation |
Relaxation in Human Ureter (Adrenoceptor – Isoprenaline)
Reference number: B071
| Assay type: | GU |
| Tissue: | Human Ureter (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Isoprenaline |
| Study Type: | Organ bath |
| Functional Endpoint: | Relaxation |
Contraction in Human Urethra (Adrenoceptor – Phenylephrine)
Reference number: B072
| Assay type: | GU |
| Tissue: | Human Urethra (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Phenylephrine |
| Study Type: | Organ bath |
| Functional Endpoint: | Contractility |
Contraction in Human Uterus (Vasopressin & Oxytocin Receptor – Oxytocin)
Reference number: B078
| Assay type: | GU |
| Tissue: | Human Uterus (Healthy) |
| Target: | Vasopressin & oxytocin receptors |
| Control Compound: | Oxytocin |
| Study Type: | Organ bath |
| Functional Endpoint: | Contractility |
Contraction in Human Uterus (Vasopressin & Oxytocin Receptor – Vasopressin)
Reference number: B079
| Assay type: | GU |
| Tissue: | Human Uterus (Healthy) |
| Target: | Vasopressin & oxytocin receptors |
| Control Compound: | Vasopressin |
| Study Type: | Organ bath |
| Functional Endpoint: | Contractility |
Relaxation in Human Uterus (Nitric Oxide Donor)
Reference number: B081
| Assay type: | GU |
| Tissue: | Human Uterus (Healthy) |
| Target: | Nitric oxide donor |
| Control Compound: | SNP |
| Study Type: | Organ bath |
| Functional Endpoint: | Relaxation |
Relaxation in Human Uterus (Adrenoceptor – Isoprenaline)
Reference number: B082
| Assay type: | GU |
| Tissue: | Human Uterus (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Isoprenaline |
| Study Type: | Organ bath |
| Functional Endpoint: | Relaxation |
Relaxation in Human Uterus (Calcium Channels)
Reference number: B083
| Assay type: | GU |
| Tissue: | Human Uterus (Healthy) |
| Target: | Calcium channels |
| Control Compound: | Isradipine |
| Study Type: | Organ bath |
| Functional Endpoint: | Relaxation |
Contractile Force in Electrically Stimulated Human Colon (Acetylcholine Esterase)
Reference number: B086
| Assay type: | GI Tract |
| Tissue: | Human Stomach (Healthy) |
| Target: | Acetylcholine esterase |
| Control Compound: | Galantamine |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractility |
Contractile Force in Electrically Stimulated Human Colon (Opioid & Opioid-Like Receptors)
Reference number: B087
| Assay type: | GI Tract |
| Tissue: | Human Colon |
| Target: | Opioid & opioid-like receptors |
| Control Compound: | Meptazinol |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractility |
Contractile Force in Electrically Stimulated Human Stomach (Motilin Receptor)
Reference number: B092
| Assay type: | GI Tract |
| Tissue: | Human Stomach (Healthy) |
| Target: | Motilin receptor |
| Control Compound: | Erythromycin |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractility |
Permeability in Healthy Human Gastrointestinal Mucosa
Reference number: B093
| Assay type: | GI Tract |
| Tissue: | Human Gastrointestinal Mucosa |
| Target: | N/A |
| Control Compound: | Multiple |
| Study Type: | Ussing chamber |
| Functional Endpoint: | Permeability |
Ion Channel Function in Isolated Healthy Human Gastrointestinal Mucosa (Chloride Channels)
Reference number: B094
| Assay type: | GI Tract |
| Tissue: | Human Gastrointestinal Mucosa (Healthy) |
| Target: | Chloride channels |
| Control Compound: | Cholera toxin |
| Study Type: | Ussing chamber |
| Functional Endpoint: | Ion channel function |
Contractile Force in Electrically Stimulated Human Ventricular Trabeculae Muscle (Adrenoceptor)
Reference number: B095
| Assay type: | Cardiac Muscle |
| Tissue: | Human Ventricular Trabeculae Muscle (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Isoprenaline |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractility |
Contractile Force in Eletrically Stimulated Human Ventricular Trabeculae Muscle (Acetylcholine Receptor)
Reference number: B096
| Assay type: | Cardiac Muscle |
| Tissue: | Human Ventricular Trabeculae Muscle (Healthy) |
| Target: | Acetylcholine receptor |
| Control Compound: | Acetylcholine |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractility |
Vasoconstriction in Human Subcutaneous Resistance Arteries (5-HT Receptor)
Reference number: B097
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | 5-HT receptor |
| Control Compound: | 5-HT |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasoconstriction |
Bronchodilatation in Healthy Human Secondary Airways (VIP & PACAP Receptors)
Reference number: B098
| Assay type: | Respiratory |
| Tissue: | Human Secondary Airways (Healthy) |
| Target: | VIP & PACAP |
| Control Compound: | Vasoactive Intestinal Polypeptide (VIP) |
| Study Type: | Organ bath |
| Functional Endpoint: | Bronchodilatation |
Bronchoconstriction in Healthy Human Tertiary or Lower Airways (Lopoxin, Oxoeiconsanoid and Resolvin E1)
Reference number: B099
| Assay type: | Respiratory |
| Tissue: | Human Secondary Airways (Healthy) |
| Target: | VIP & PACAP |
| Control Compound: | Vasoactive Intestinal Polypeptide (VIP) |
| Study Type: | Organ bath |
| Functional Endpoint: | Bronchodilatation |
IBD Culture Study Crohn’s or Ulcerative Colitis (UC)
Reference number: B106
| Tissue: | Human GI Mucosal Explants (IBD) |
| Target: | p38 MAP Kinase |
| Control Compound: | BIRB796 |
| Study Type: | Ex vivo Cultures |
| Functional Endpoint: | Inflammation |
Contraction in Human Bladder (Muscarinic – Carbachol)
Reference number: B107
| Assay type: | GU |
| Tissue: | Human Bladder (Healthy) |
| Target: | Muscarinic receptors |
| Control Compound: | Carbachol |
| Study Type: | Organ bath |
| Functional Endpoint: | Contractility |
Contraction, Relaxation in Human Bladder Electrically Stimulated
Reference number: B108
| Assay type: | GU |
| Tissue: | Human Bladder (Healthy) |
| Target: | Muscarinic/ beta-adrenergic receptors/ ion channels |
| Control Compound: | Carbachol/ isoproterenol/ retigabine |
| Study Type: | Organ bath |
| Functional Endpoint: | Modulation of EFS-induced contractions |
Permeability in IBD Human Gastrointestinal Mucosa
Reference number: B109
| Assay type: | GI Tract |
| Tissue: | Human Diseased (IBD) Gastrointestinal Mucosa |
| Target: | N/A |
| Control Compound: | Multiple |
| Study Type: | Ussing chamber |
| Functional Endpoint: | Permeability |
Pulmonary Artery Tone
Reference number: B110
| Assay type: | GU / Blood Vessels |
| Tissue: | Human Pulmonary Artery (Healthy) / Human Pulmonary Artery (Healthy – Denuded) |
| Target: | Muscarinic Receptors/ Angiotensin receptor/ Nitric oxide donor/ Endothelin receptor/ Prostacyclin receptor/ Prostaglandin EP2 receptor/ Prostaglandin EP4 receptor/ Beta adrenergic receptor |
| Control Compound: | Acetylcholine/ Angiotensin II/ Sildenafil/ U46619/ Endothelin-1/ Iloprost/ Bosentan/ Wire Myography |
| Study Type: | Organ bath |
| Functional Endpoint: | Contractile force/ Contraction/ Relaxation/ Vasoconstriction/ Vasodilatation |
Skin Inflammation LPS (Acne) (Systemic/Topical)
Reference number: B111
| Assay type: | Skin |
| Tissue: | Human Skin Biopsies (Healthy) |
| Target: | TLR4/TLR2 Pathway/ Glucocorticoid receptors/ NLRP3 Inflammasome |
| Control Compound: | Betnovate/ Nitric Oxide |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Cytokine release |
Lung PCLS Culture
Reference number: B112
| Assay type: | Respiratory |
| Tissue: | Human Precision Cut Lung Slice (PCLS) |
| Target: | TLR4/TLR2 Pathway/ Glucocorticoid receptors/ NLRP3 Inflammasome |
| Control Compound: | Fluticasone/ Roflumilast |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Cytokine release |
Skin Culture Induced Psoriasis Model (Systemic/Topical)
Reference number: B113
| Assay type: | Skin |
| Tissue: | Human Skin Biopsies (Healthy) |
| Target: |
Glucocorticoid receptors/ Retinoid receptors/ Th17 Pathway |
| Control Compound: | Retigabine/ Betnovate/ Calcipotriol/ ROR gamma antagonist GSK2981278/ Dovonex (topical calcipotriol)/ Dovobet (topical calcipotriol plus Betamethasone)/ Zorac/ Dermovate/ Phase1/Phase 2 metabolic enzymes |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Cytokine release/ Gene Expression |
Relaxation in Human LES
Reference number: B114
| Assay type: | Gastrointestinal (GI) Tract |
| Tissue: | Human Lower esophageal sphincter |
| Target: | TGR5 receptor |
| Control Compound: | Carbachol/ Isoprenaline |
| Study Type: | Organ bath |
| Functional Endpoint: | Contractile force/ Relaxation |
Contraction in Human LES
Reference number: B115
| Assay type: | Gastrointestinal (GI) Tract |
| Tissue: | Human Lower esophageal sphincter |
| Target: | TGR5 receptor |
| Control Compound: | Carbachol/ Isoprenaline |
| Study Type: | Organ bath |
| Functional Endpoint: | Contractile force/Contraction |
GI Metabolism
Reference number: B116
| Assay type: | Gastrointestinal (GI) Tract |
| Tissue: | Human Colon/ Human Gastrointestinal Mucosa (Healthy) |
| Target: | Phase1/Phase 2 metabolic enzymes |
| Control Compound: | Phase1/Phase 2 metabolic enzymes |
| Study Type: | Ussing chamber |
| Functional Endpoint: | Metabolism |
Healthy Skin Culture
Reference number: B117
| Assay type: | Skin |
| Tissue: | Human Skin Biopsies (Healthy) |
| Target: | Study Dependant |
| Control Compound: | LPS |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Inflammation |
Skin Biopsies Atopic Dermatitis (Systemic/Topical)
Reference number: B118
| Assay type: | Skin |
| Tissue: | Skin Disease Biopsies |
| Target: | Study Dependant |
| Control Compound: | Betamethasone |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Inflammation |
Skin Biopsies Atopic Psoraisis (Systemic/Topical)
Reference number: B119
| Assay type: | Skin |
| Tissue: | Skin Disease Biopsies |
| Target: | Study Dependant |
| Control Compound: | Betamethasone |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Inflammation |
Skin Inflammation PHA (Systemic/Topical)
Reference number: B120
| Assay type: | Skin |
| Tissue: | Human Skin Biopsies (Healthy) |
| Target: | Study Dependant |
| Control Compound: | Betamethasone |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Inflammation |
Skin Culture Induced Atopic Dermatitis Model (Systemic/Topical)
Reference number: B121
| Assay type: | Skin |
| Tissue: | Human Skin Biopsies (Healthy) |
| Target: | TH2 Pathway |
| Control Compound: | Betamethasone |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Inflammation |
Mouse IBD Model – Crohn’s or Ulcerative Colitis (UC)
Reference number: B122
| Tissue: | Murine GI mucosal explants (IBD) |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Inflammation |
Contractility of Rat Uterus (Vasopressin & Oxytocin Receptor)
Reference number: B123
| Assay type: | Genitourinary (GU) |
| Tissue: | Rat uterus (healthy) |
| Target: | Vasopressin & oxytocin receptors |
| Control Compound: | Oxytocin |
| Study Type: | Organ bath |
| Functional Endpoint: | Contractility |
Ex Vivo Skin Explants and Bioengineered 3D Human Skin In Vitro Models
Reference number: B124
| Assay type: | Skin |
| Tissue: | Human Skin Disease Biopsies, Human Skin (Surgical) |
| Target: | Study dependant |
| Control Compound: | Study dependant |
| Study Type: | 3D Cell Culture |
| Functional Endpoint: | Study dependant |
3D Bioengineered Model for Inflammatory Bowel Disease
Reference number: B125
| Assay type: | Inflammatory Bowel Disease |
| Tissue: | Bioengineered human IBD tissue |
| Target: | Study dependant |
| Control Compound: | BIRB796, 5-ASA, Prednisolone, Tofacitinib |
| Study Type: | 3D Cell Culture |
| Functional Endpoint: | Inflammation, Fibrosis/Remodelling, Cytokine release, Gene expression |
Transport Studies in 3D Bioengineered IBD Model
Reference number: B126
| Assay type: | Inflammatory Bowel Disease |
| Tissue: | Bioengineered human IBD tissue |
| Target: | N/A |
| Control Compound: | BIRB796, 5-ASA, Prednisolone, Tofacitinib |
| Study Type: | 3D Cell Culture |
| Functional Endpoint: | Ion channel function, Permeability, Metabolism |
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