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Drug Discovery Assay Catalog

REPROCELL has investigated the safety and efficacy of thousands of compounds for its Pharma clients since 2002.

This human tissue assay catalog contains only a small number of our experimental endpoints, that we can list as a public example of our work. Here you can browse some of our real examples of ex vivo pharmacological data – with over 100 drug targets, tissue types, and compounds.

REPROCELL Biopta™ – the human tissue experts

If you have any inquiries about our drug discovery assays, or to discuss your particular contract reasearch project needs, please contact us.

Search assays by:

Assay type Tissue Target Control compound Study type Functional endpoint

Total assays available:

Vasoconstriction in Human Coronary Arteries (5-HT Receptor – 5-HT)

Reference number: B003

Assay type:	Blood Vessels
Tissue:	Human Coronary Artery (Healthy)
Target:	5-HT receptor
Control Compound:	5-HT
Study Type:	Wire Myography
Functional Endpoint:	Vasoconstriction

Vasoconstriction in Human Coronary Arteries (Opioid and Opioid-Like Receptors)

Reference number: B004

Assay type:	Blood Vessels
Tissue:	Human Coronary Artery (Healthy)
Target:	Opioid & opioid-like receptors
Control Compound:	Mephedrone
Study Type:	Wire Myography
Functional Endpoint:	Vasoconstriction

Vasoconstriction in Human Coronary Arteries (Angiotensin Receptor)

Reference number: B007

Assay type:	Blood Vessels
Tissue:	Human Coronary Artery (Healthy)
Target:	Angiotensin receptor
Control Compound:	Angiotensin II
Study Type:	Organ bath
Functional Endpoint:	Vasoconstriction

Vasoconstriction in Human Coronary Arteries (Vasopressin & Oxytocin Receptors)

Reference number: B008

Assay type:	Blood Vessels
Tissue:	Human Coronary Artery (Healthy)
Target:	Vasopressin & oxytocin receptors
Control Compound:	8-arginine vasopressin
Study Type:	Organ bath
Functional Endpoint:	Vasoconstriction

Vasodilatation in Human Subcutaneous Resistance Arteries (Acetylcholine Receptor)

Reference number: B016

Assay type:	Blood Vessels
Tissue:	Human Subcutaneous Resistance Artery (Healthy)
Target:	Acetylcholine receptor
Control Compound:	Acetylcholine
Study Type:	Wire Myography
Functional Endpoint:	Vasodilatation

Vasodilatation in Human Subcutaneous Resistance Arteries (Vasopressin & Oxytocin Receptors)

Reference number: B017

Assay type:	Blood Vessels
Tissue:	Human Subcutaneous Resistance Artery (Healthy)
Target:	Vasopressin & oxytocin receptors
Control Compound:	Desmopressin
Study Type:	Wire Myography
Functional Endpoint:	Vasodilatation

Vasodilatation in Human Subcutaneous Resistance Arteries (Nitric Oxide Donor)

Reference number: B019

Assay type:	Blood Vessels
Tissue:	Human Subcutaneous Resistance Artery (Healthy)
Target:	Nitric oxide donor
Control Compound:	SNP
Study Type:	Wire Myography
Functional Endpoint:	Vasodilatation

Vasoconstriction in Human Subcutaneous Resistance Arteries (Adrenoceptor)

Reference number: B020

Assay type:	Blood Vessels
Tissue:	Human Subcutaneous Resistance Artery (Healthy)
Target:	Adrenoceptor
Control Compound:	Phenylephrine
Study Type:	Wire Myography
Functional Endpoint:	Vasodilatation

Vasoconstriction in Human Subcutaneous Resistance Arteries (Prostanoid Receptor)

Reference number: B021

Assay type:	Blood Vessels
Tissue:	Human Subcutaneous Resistance Artery (Healthy)
Target:	Prostanoid receptor
Control Compound:	U46619
Study Type:	Wire Myography
Functional Endpoint:	Vasoconstriction

Vasodilatation in Ischaemic Human Subcutaneous Resistance Arteries (Bradykinin Receptor)

Reference number: B022

Assay type:	Blood Vessels
Tissue:	Human Subcutaneous Resistance Artery (Ischaemic)
Target:	Bradykinin receptor
Control Compound:	Bradykinin
Study Type:	Wire Myography
Functional Endpoint:	Vasodilatation

Vasoconstriction in Human Coronary Arteries (5-HT Receptor – Sumatriptan)

Reference number: B028

Assay type:	Blood Vessels
Tissue:	Human Coronary Artery (Healthy)
Target:	5-HT receptor
Control Compound:	Sumatriptan
Study Type:	Wire Myography
Functional Endpoint:	Vasoconstriction

Vasoconstriction in Denuded Human Coronary Arteries (5-HT Receptor)

Reference number: B030

Assay type:	Blood Vessels
Tissue:	Human Coronary Artery (Healthy – Denuded)
Target:	5-HT receptor
Control Compound:	5-HT
Study Type:	Organ bath
Functional Endpoint:	Vasoconstriction

Vasodilatation in Human Subcutaneous Resistance Arteries (PDE3 Receptor)

Reference number: B034

Assay type:	Blood Vessels
Tissue:	Human Subcutaneous Resistance Artery (Healthy)
Target:	PDE3
Control Compound:	Milrinone
Study Type:	Wire Myography
Functional Endpoint:	Vasodilatation

Vasodilatation in Human Subcutaneous Resistance Arteries (Bradykinin Receptor)

Reference number: B035

Assay type:	Blood Vessels
Tissue:	Human Subcutaneous Resistance Artery (Healthy)
Target:	Bradykinin receptor
Control Compound:	Bradykinin
Study Type:	Wire Myography
Functional Endpoint:	Vasodilatation

Vasoconstriction in Atherosclerotic Human Subcutaneous Resistance Arteries (Angiotensin Receptor)

Reference number: B037

Assay type:	Blood Vessels
Tissue:	Human Resistance Artery (Atherosclerotic)
Target:	Angiotensin receptor
Control Compound:	PDA-angiotensin 1
Study Type:	Wire Myography
Functional Endpoint:	Vasoconstriction

Vasodilatation in Ischaemic Human Subcutaneous Resistance Arteries (Nitric Oxide Donor)

Reference number: B038

Assay type:	Blood Vessels
Tissue:	Human Subcutaneous Resistance Artery (Ischaemic)
Target:	Nitric oxide donor
Control Compound:	SNP
Study Type:	Wire Myography
Functional Endpoint:	Vasodilatation

Vasodilatation in Human Skeletal Muscle Arteries (Acetycholine Receptor)

Reference number: B039

Assay type:	Blood Vessels
Tissue:	Human Skeletal Muscle Artery (Healthy)
Target:	Acetylcholine receptor
Control Compound:	Acetylcholine
Study Type:	Wire Myography
Functional Endpoint:	Vasodilatation

Vasodilatation in Human Skeletal Muscle Arteries (Nitric Oxide Donor)

Reference number: B040

Assay type:	Blood Vessels
Tissue:	Human Skeletal Muscle Artery (Healthy)
Target:	Nitric oxide donor
Control Compound:	SNP
Study Type:	Wire Myography
Functional Endpoint:	Vasodilatation

Contractile Force in Electrically Stimulated Human Atrial Pectinate Muscle (Adrenoceptors – Isoprenaline)

Reference number: B043

Assay type:	Cardiac Muscle
Tissue:	Human Atrial Pectinate Muscle (Healthy)
Target:	Adrenoceptor
Control Compound:	Isoprenaline
Study Type:	EFS organ bath
Functional Endpoint:	Contractility

Contractile Force in Electrically Stimulated Human Ventricular Trabeculae Muscle (5-HT Receptor)

Reference number: B047

Assay type:	Cardiac Muscle
Tissue:	Human Ventricular Trabeculae Muscle (Healthy)
Target:	5-HT receptor
Control Compound:	5-HT
Study Type:	EFS organ bath
Functional Endpoint:	Contractility

Contractile Force in Electrically Stimulated Human Atrial Pectinate Muscle (5-HT Receptor)

Reference number: B048

Assay type:	Cardiac Muscle
Tissue:	Human Atrial Pectinate Muscle (Healthy)
Target:	5-HT receptor
Control Compound:	5-HT
Study Type:	EFS organ bath
Functional Endpoint:	Contractility

Contractile Force in Electrically Stimulated Human Atrial Pectinate Muscle (Adrenoceptors – Salbutamol)

Reference number: B049

Assay type:	Cardiac Muscle
Tissue:	Human Atrial Pectinate Muscle (Healthy)
Target:	Adrenoceptor
Control Compound:	Salbutamol
Study Type:	EFS organ bath
Functional Endpoint:	Contractility

Contractile Force in Electrically Stimulated Human Atrial Pectinate Muscle (PDE3 Receptor)

Reference number: B050

Assay type:	Cardiac Muscle
Tissue:	Human Atrial Pectinate Muscle (Healthy)
Target:	PDE3
Control Compound:	Milrinone
Study Type:	EFS organ bath
Functional Endpoint:	Contractility

Bronchodilatation in Secondary Healthy Human Airways (Adrenoceptor – Isoprenaline)

Reference number: B052

Assay type:	Respiratory
Tissue:	Human Tertiary Or Lower Airways (Healthy)
Target:	Adrenoceptor
Control Compound:	Isoprenaline
Study Type:	Wire Myography
Functional Endpoint:	Bronchodilatation

Bronchoconstriction in Secondary Asthmatic Human Airways (Acetylcholine Receptor)

Reference number: B053

Assay type:	Respiratory
Tissue:	Human Secondary Airways (Asthmatic)
Target:	Acetylcholine receptor
Control Compound:	Carbachol
Study Type:	Organ bath
Functional Endpoint:	Bronchoconstriction

Bronchodilatation in Secondary Asthmatic Human Airways (Adrenoceptor)

Reference number: B054

Assay type:	Respiratory
Tissue:	Human Secondary Airways (Asthmatic)
Target:	Adrenoceptor
Control Compound:	Salbutamol
Study Type:	Organ bath
Functional Endpoint:	Bronchodilatation

Bronchoconstriction in Tertiary or Lower Healthy Human Airways (Prostanoid Receptor)

Reference number: B055

Assay type:	Respiratory
Tissue:	Human Tertiary Or Lower Airways (Healthy)
Target:	Prostanoid receptor
Control Compound:	U46619
Study Type:	Wire Myography
Functional Endpoint:	Bronchoconstriction

Bronchodilatation in Tertiary or Lower Healthy Human Airways (Adrenoceptor – Salbutamol)

Reference number: B056

Assay type:	Respiratory
Tissue:	Human Tertiary Or Lower Airways (Healthy)
Target:	Adrenoceptor
Control Compound:	Salbutamol
Study Type:	Wire Myography
Functional Endpoint:	Bronchodilatation

Bronchoconstriction in Tertiary or Lower Healthy Human Airways (Acetylcholine Receptor)

Reference number: B057

Assay type:	Respiratory
Tissue:	Human Tertiary Or Lower Airways (Healthy)
Target:	Acetylcholine receptor
Control Compound:	Acetylcholine
Study Type:	Wire Myography
Functional Endpoint:	Bronchoconstriction

Bronchodilatation in Tertiary or Lower Healthy Human Airways (Adrenoceptor – Isoprenaline)

Reference number: B058

Assay type:	Respiratory
Tissue:	Human Tertiary Or Lower Airways (Healthy)
Target:	Adrenoceptor
Control Compound:	Isoprenaline
Study Type:	Wire Myography
Functional Endpoint:	Bronchodilatation

Bronchodilatation in Tertiary or Lower Airways COPD (Adrenoceptor)

Reference number: B059

Assay type:	Respiratory
Tissue:	Human Tertiary Or Lower Airways (COPD)
Target:	Adrenoceptor
Control Compound:	Isoprenaline
Study Type:	Wire Myography
Functional Endpoint:	Bronchodilatation

Bronchoconstriction in Denuded Secondary Healthy Human Airways (Acetylcholine Receptor)

Reference number: B060

Assay type:	Respiratory
Tissue:	Human Secondary Airways (Healthy – Denuded)
Target:	Acetylcholine receptor
Control Compound:	Carbachol
Study Type:	Organ bath
Functional Endpoint:	Bronchoconstriction

Bronchoconstriction in Denuded Secondary Healthy Human Airways (Histamine Receptor)

Reference number: B061

Assay type:	Respiratory
Tissue:	Human Secondary Airways (Healthy – Denuded)
Target:	Histamine receptor
Control Compound:	Histamine
Study Type:	Organ bath
Functional Endpoint:	Bronchoconstriction

Bronchodilatation in Tertiary or Lower Human Airways (Adrenoceptors – Formoterol)

Reference number: B065

Assay type:	Respiratory
Tissue:	Human Tertiary Or Lower Airways (Healthy)
Target:	Adrenoceptor
Control Compound:	Formoterol
Study Type:	Wire Myography
Functional Endpoint:	Bronchodilatation

Bronchodilatation in Tertiary or Lower Human Airways (Adrenoceptors – Salbutamol)

Reference number: B066

Assay type:	Respiratory
Tissue:	Human Tertiary Or Lower Airways (Healthy)
Target:
Control Compound:	Salbutamol
Study Type:	Wire Myography
Functional Endpoint:	Bronchodilatation

Bronchodilatation in Tertiary or Lower Asthmatic Human Airways (Adrenoceptor – Formoterol)

Reference number: B067

Assay type:	Respiratory
Tissue:	Human Tertiary Or Lower Airways (Asthmatic)
Target:	Adrenoceptor
Control Compound:	Formoterol
Study Type:	Wire Myography
Functional Endpoint:	Bronchodilatation

Bronchodilatation in Tertiary or Lower Asthmatic Human Airways (Adrenoceptor – Salbutamol)

Reference number: B068

Assay type:	Respiratory
Tissue:	Human Tertiary Or Lower Airways (Asthmatic)
Target:	Adrenoceptor
Control Compound:	Salbutamol
Study Type:	Wire Myography
Functional Endpoint:	Bronchodilatation

Bronchodilatation in Tertiary or Lower Asthmatic Human Airways (Adrenoceptor – Salmeterol)

Reference number: B069

Assay type:	Respiratory
Tissue:	Human Tertiary Or Lower Airways (Asthmatic)
Target:	Adrenoceptor
Control Compound:	Salmeterol
Study Type:	Wire Myography
Functional Endpoint:	Bronchodilatation

Relaxation in Human Bladder (Adrenoceptor – Isoproterenol)

Reference number: B070

Assay type:	GU
Tissue:	Human Bladder (Healthy)
Target:	Adrenoceptor
Control Compound:	Isoproterenol
Study Type:	Organ bath
Functional Endpoint:	Relaxation

Relaxation in Human Ureter (Adrenoceptor – Isoprenaline)

Reference number: B071

Assay type:	GU
Tissue:	Human Ureter (Healthy)
Target:	Adrenoceptor
Control Compound:	Isoprenaline
Study Type:	Organ bath
Functional Endpoint:	Relaxation

Contraction in Human Urethra (Adrenoceptor – Phenylephrine)

Reference number: B072

Assay type:	GU
Tissue:	Human Urethra (Healthy)
Target:	Adrenoceptor
Control Compound:	Phenylephrine
Study Type:	Organ bath
Functional Endpoint:	Contractility

Contraction in Human Uterus (Vasopressin & Oxytocin Receptor – Oxytocin)

Reference number: B078

Assay type:	GU
Tissue:	Human Uterus (Healthy)
Target:	Vasopressin & oxytocin receptors
Control Compound:	Oxytocin
Study Type:	Organ bath
Functional Endpoint:	Contractility

Contraction in Human Uterus (Vasopressin & Oxytocin Receptor – Vasopressin)

Reference number: B079

Assay type:	GU
Tissue:	Human Uterus (Healthy)
Target:	Vasopressin & oxytocin receptors
Control Compound:	Vasopressin
Study Type:	Organ bath
Functional Endpoint:	Contractility

Relaxation in Human Uterus (Nitric Oxide Donor)

Reference number: B081

Assay type:	GU
Tissue:	Human Uterus (Healthy)
Target:	Nitric oxide donor
Control Compound:	SNP
Study Type:	Organ bath
Functional Endpoint:	Relaxation

Relaxation in Human Uterus (Adrenoceptor – Isoprenaline)

Reference number: B082

Assay type:	GU
Tissue:	Human Uterus (Healthy)
Target:	Adrenoceptor
Control Compound:	Isoprenaline
Study Type:	Organ bath
Functional Endpoint:	Relaxation

Relaxation in Human Uterus (Calcium Channels)

Reference number: B083

Assay type:	GU
Tissue:	Human Uterus (Healthy)
Target:	Calcium channels
Control Compound:	Isradipine
Study Type:	Organ bath
Functional Endpoint:	Relaxation

Contractile Force in Electrically Stimulated Human Colon (Acetylcholine Esterase)

Reference number: B086

Assay type:	GI Tract
Tissue:	Human Stomach (Healthy)
Target:	Acetylcholine esterase
Control Compound:	Galantamine
Study Type:	EFS organ bath
Functional Endpoint:	Contractility

Contractile Force in Electrically Stimulated Human Stomach (Motilin Receptor)

Reference number: B092

Assay type:	GI Tract
Tissue:	Human Stomach (Healthy)
Target:	Motilin receptor
Control Compound:	Erythromycin
Study Type:	EFS organ bath
Functional Endpoint:	Contractility

Permeability in Healthy Human Gastrointestinal Mucosa

Reference number: B093

Assay type:	GI Tract
Tissue:	Human Gastrointestinal Mucosa
Target:	N/A
Control Compound:	Multiple
Study Type:	Ussing chamber
Functional Endpoint:	Permeability

Ion Channel Function in Isolated Healthy Human Gastrointestinal Mucosa (Chloride Channels)

Reference number: B094

Assay type:	GI Tract
Tissue:	Human Gastrointestinal Mucosa (Healthy)
Target:	Chloride channels
Control Compound:	Cholera toxin
Study Type:	Ussing chamber
Functional Endpoint:	Ion channel function

Contractile Force in Electrically Stimulated Human Ventricular Trabeculae Muscle (Adrenoceptor)

Reference number: B095

Assay type:	Cardiac Muscle
Tissue:	Human Ventricular Trabeculae Muscle (Healthy)
Target:	Adrenoceptor
Control Compound:	Isoprenaline
Study Type:	EFS organ bath
Functional Endpoint:	Contractility

Contractile Force in Eletrically Stimulated Human Ventricular Trabeculae Muscle (Acetylcholine Receptor)

Reference number: B096

Assay type:	Cardiac Muscle
Tissue:	Human Ventricular Trabeculae Muscle (Healthy)
Target:	Acetylcholine receptor
Control Compound:	Acetylcholine
Study Type:	EFS organ bath
Functional Endpoint:	Contractility

Vasoconstriction in Human Subcutaneous Resistance Arteries (5-HT Receptor)

Reference number: B097

Assay type:	Blood Vessels
Tissue:	Human Subcutaneous Resistance Artery (Healthy)
Target:	5-HT receptor
Control Compound:	5-HT
Study Type:	Wire Myography
Functional Endpoint:	Vasoconstriction

Bronchodilatation in Healthy Human Secondary Airways (VIP & PACAP Receptors)

Reference number: B098

Assay type:	Respiratory
Tissue:	Human Secondary Airways (Healthy)
Target:	VIP & PACAP
Control Compound:	Vasoactive Intestinal Polypeptide (VIP)
Study Type:	Organ bath
Functional Endpoint:	Bronchodilatation

Bronchoconstriction in Healthy Human Tertiary or Lower Airways (Lopoxin, Oxoeiconsanoid and Resolvin E1)

Reference number: B099

Assay type:	Respiratory
Tissue:	Human Secondary Airways (Healthy)
Target:	VIP & PACAP
Control Compound:	Vasoactive Intestinal Polypeptide (VIP)
Study Type:	Organ bath
Functional Endpoint:	Bronchodilatation

IBD Culture Study Crohn’s or Ulcerative Colitis (UC)

Reference number: B106

Tissue:	Inflammatory Bowel Disease (IBD)
Target:	p38 MAP Kinase
Control Compound:	BIRB796
Study Type:	Ex vivo Cultures
Functional Endpoint:	Inflammation

Contraction in Human Bladder (Muscarinic – Carbachol)

Reference number: B107

Assay type:	GU
Tissue:	Human Bladder (Healthy)
Target:	Muscarinic receptors
Control Compound:	Carbachol
Study Type:	Organ bath
Functional Endpoint:	Contractility

Contraction, Relaxation in Human Bladder Electrically Stimulated

Reference number: B108

Assay type:	GU
Tissue:	Human Bladder (Healthy)
Target:	Muscarinic/ beta-adrenergic receptors/ ion channels
Control Compound:	Carbachol/ isoproterenol/ retigabine
Study Type:	Organ bath
Functional Endpoint:	Modulation of EFS-induced contractions

Permeability in IBD Human Gastrointestinal Mucosa

Reference number: B109

Assay type:	Inflammatory Bowel Disease (IBD)
Tissue:	Human Diseased (IBD) Gastrointestinal Mucosa
Target:	N/A
Control Compound:	Multiple
Study Type:	Ussing chamber
Functional Endpoint:	Permeability

Pulmonary Artery Tone

Reference number: B110

Assay type:	GU / Blood Vessels
Tissue:	Human Pulmonary Artery (Healthy) / Human Pulmonary Artery (Healthy – Denuded)
Target:	Muscarinic Receptors/ Angiotensin receptor/ Nitric oxide donor/ Endothelin receptor/ Prostacyclin receptor/ Prostaglandin EP2 receptor/ Prostaglandin EP4 receptor/ Beta adrenergic receptor
Control Compound:	Acetylcholine/ Angiotensin II/ Sildenafil/ U46619/ Endothelin-1/ Iloprost/ Bosentan/ Wire Myography
Study Type:	Organ bath
Functional Endpoint:	Contractile force/ Contraction/ Relaxation/ Vasoconstriction/ Vasodilatation

Skin Inflammation LPS (Acne) (Systemic/Topical)

Reference number: B111

Assay type:	Skin
Tissue:	Human Skin Biopsies (Healthy)
Target:	TLR4/TLR2 Pathway/ Glucocorticoid receptors/ NLRP3 Inflammasome
Control Compound:	Betnovate/ Nitric Oxide
Study Type:	Ex vivo cultures
Functional Endpoint:	Cytokine release

Lung PCLS Culture

Reference number: B112

Assay type:	Respiratory
Tissue:	Human Precision Cut Lung Slice (PCLS)
Target:	TLR4/TLR2 Pathway/ Glucocorticoid receptors/ NLRP3 Inflammasome
Control Compound:	Fluticasone/ Roflumilast
Study Type:	Ex vivo cultures
Functional Endpoint:	Cytokine release

Skin Culture Induced Psoriasis Model (Systemic/Topical)

Reference number: B113

Assay type:	Skin
Tissue:	Human Skin Biopsies (Healthy)
Target:	Glucocorticoid receptors/ Retinoid receptors/ Th17 Pathway
Control Compound:	Retigabine/ Betnovate/ Calcipotriol/ ROR gamma antagonist GSK2981278/ Dovonex (topical calcipotriol)/ Dovobet (topical calcipotriol plus Betamethasone)/ Zorac/ Dermovate/ Phase1/Phase 2 metabolic enzymes
Study Type:	Ex vivo cultures
Functional Endpoint:	Cytokine release/ Gene Expression

Relaxation in Human LES

Reference number: B114

Assay type:	Gastrointestinal (GI) Tract
Tissue:	Human Lower esophageal sphincter
Target:	TGR5 receptor
Control Compound:	Carbachol/ Isoprenaline
Study Type:	Organ bath
Functional Endpoint:	Contractile force/ Relaxation

Contraction in Human LES

Reference number: B115

Assay type:	Gastrointestinal (GI) Tract
Tissue:	Human Lower esophageal sphincter
Target:	TGR5 receptor
Control Compound:	Carbachol/ Isoprenaline
Study Type:	Organ bath
Functional Endpoint:	Contractile force/Contraction

GI Metabolism

Reference number: B116

Assay type:	Gastrointestinal (GI) Tract
Tissue:	Human Colon/ Human Gastrointestinal Mucosa (Healthy)
Target:	Phase1/Phase 2 metabolic enzymes
Control Compound:	Phase1/Phase 2 metabolic enzymes
Study Type:	Ussing chamber
Functional Endpoint:	Metabolism

Healthy Skin Culture

Reference number: B117

Assay type:	Skin
Tissue:	Human Skin Biopsies (Healthy)
Target:	Study Dependant
Control Compound:	LPS
Study Type:	Ex vivo cultures
Functional Endpoint:	Inflammation

Skin Biopsies Atopic Dermatitis (Systemic/Topical)

Reference number: B118

Assay type:	Skin
Tissue:	Skin Disease Biopsies
Target:	Study Dependant
Control Compound:	Betamethasone
Study Type:	Ex vivo cultures
Functional Endpoint:	Inflammation

Skin Biopsies Atopic Psoraisis (Systemic/Topical)

Reference number: B119

Assay type:	Skin
Tissue:	Skin Disease Biopsies
Target:	Study Dependant
Control Compound:	Betamethasone
Study Type:	Ex vivo cultures
Functional Endpoint:	Inflammation

Skin Inflammation PHA (Systemic/Topical)

Reference number: B120

Assay type:	Skin
Tissue:	Human Skin Biopsies (Healthy)
Target:	Study Dependant
Control Compound:	Betamethasone
Study Type:	Ex vivo cultures
Functional Endpoint:	Inflammation

Skin Culture Induced Atopic Dermatitis Model (Systemic/Topical)

Reference number: B121

Assay type:	Skin
Tissue:	Human Skin Biopsies (Healthy)
Target:	TH2 Pathway
Control Compound:	Betamethasone
Study Type:	Ex vivo cultures
Functional Endpoint:	Inflammation

Mouse IBD Model – Crohn’s or Ulcerative Colitis (UC)

Reference number: B122

Assay Type:	Inflammatory Bowel Disease (IBD)
Tissue:	Murine GI mucosal explants (IBD)
Study Type:	Ex vivo cultures
Functional Endpoint:	Inflammation

Contractility of Rat Uterus (Vasopressin & Oxytocin Receptor)

Reference number: B123

Assay type:	Genitourinary (GU)
Tissue:	Rat uterus (healthy)
Target:	Vasopressin & oxytocin receptors
Control Compound:	Oxytocin
Study Type:	Organ bath
Functional Endpoint:	Contractility

Ex Vivo Skin Explants and Bioengineered 3D Human Skin In Vitro Models

Reference number: B124

Assay type:	Skin
Tissue:	Human Skin Disease Biopsies, Human Skin (Surgical)
Target:	Study dependant
Control Compound:	Study dependant
Study Type:	3D Cell Culture
Functional Endpoint:	Study dependant

3D Bioengineered Model for Inflammatory Bowel Disease

Reference number: B125

Assay type:	Inflammatory Bowel Disease (IBD)
Tissue:	Bioengineered human IBD tissue
Target:	Study dependant
Control Compound:	BIRB796, Mesalamine/5-ASA, Prednisolone, Tofacitinib
Study Type:	3D Cell Culture
Functional Endpoint:	Inflammation, Fibrosis/Remodelling, Cytokine release, Gene expression

Transport Studies in 3D Bioengineered IBD Model

Reference number: B126

Assay type:	Inflammatory Bowel Disease (IBD)
Tissue:	Bioengineered human IBD tissue
Target:	N/A
Control Compound:	BIRB796, Mesalamine/5-ASA, Prednisolone, Tofacitinib
Study Type:	3D Cell Culture
Functional Endpoint:	Ion channel function, Permeability, Metabolism

Bioengineered Pigmented Skin Equivalent for UV and Cosmetic Testing

Reference number: B127

Tissue:	Bioengineered pigmented full thickness skin equivalent
Target:	Study dependent
Control Compound:	UVR exposure or topical application of test compound
Study Type:	3D Cell Culture
Functional Endpoint:	Transepidermal water loss (TEWL), melanin index (MI), individual topography index (ITA), histology, cytokine release, melanin distribution, epidermal melanocyte density

Bioengineered Pigmented Skin Equivalent for Wound Recovery

Reference number: B128

Tissue:	Bioengineered full thickness skin equivalent
Target:	Study dependent
Control Compound:	Wound generation (acute or diffuse) and application of test compound
Study Type:	3D Cell Culture
Functional Endpoint:	Transepidermal water loss (TEWL), gross morphology, histology, biomarker analysis

3D Bioengineered model of ageing human skin

Reference number: B129

Tissue:	Bioengineered ageing full thickness skin equivalent
Target:	Study dependent
Control Compound:	Application of test compounds
Study Type:	3D Cell Culture
Functional Endpoint:	Transepidermal water loss (TEWL), histology, cytokine release, extracellular matrix (ECM) composition

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The Power of Human Tissue Models in Preclinical Research

The Power of Human Tissue Models in Preclinical Research

Discover how human tissue models are transforming drug safety assessments and improving outcomes in preclinical research through real-world case studies.

03 October 2024

Understanding Safety Pharmacology in Human Tissues

Understanding Safety Pharmacology in Human Tissues

Explore the role of safety pharmacology in drug discovery, and the importance of human tissue studies for predicting and mitigating potential effects.

26 August 2024