Standard Full-Thickness REPROSKIN™
Our baseline model contains epidermal keratinocytes and dermal fibroblasts arranged in a physiologically relevant architecture that mimics native human skin.
For more information .
Looking to purchase REPROSKIN for your lab?
See our REPROSKIN™ Full Thickness Skin Equivalent product page.
Above: Haematoxylin and eosin (H&E) staining of the REPROSKIN full-thickness model showing a well-organised, stratified epidermis supported by a fibroblast-populated dermal compartment, replicating key structural features of native human skin.
Wound Healing Model
Evaluate skin repair and tissue regeneration
Controlled wounds are generated within the epidermis and/or dermis and monitored over several days to assess healing outcomes following treatment.
Applications:
- Advanced wound care products
- Regenerative medicines
- Topical therapeutics
- Medical devices
- Skin repair formulations
Endpoints:
- Rate of wound closure
- Histological recovery
- Barrier restoration
- Biomarker expression
- TEWL measurements
Above: Immuno-staining analysis: Three days after scalpel-induced injury, K14-positive basal keratinocytes have migrated into the wound site and expanded beyond the normal basal layer, demonstrating active re-epithelialisation and epidermal repair. K10 (green), K14 (red), nuclei (blue).
Ageing Skin Model
Investigate age-related skin biology
This model incorporates cells derived from donors over 50 years of age to reproduce features associated with skin ageing.
Applications:
- Anti-ageing skin care
- Retinoid evaluation
- Dermal regeneration products
Endpoints:
- Epidermal thickness
- Extracellular matrix production
- Collagen biomarkers
Above: H&E staining of a REPROSKIN model generated using cells from an aged donor. The model displays characteristic features associated with skin ageing, including a thinner and less organised epidermis compared with models generated from younger donors. These structural changes provide a physiologically relevant platform for investigating age-related alterations in skin biology and evaluating therapies targeting skin ageing.
Pigmented Skin Model
Represent diverse skin tones and pigmentation biology
Melanocytes are incorporated into the full-thickness skin model to create physiologically relevant pigmented tissue.
Applications:
- SPF and sunscreen testing
- UV damage studies
- Skin brightening products
- Pigmentation disorders
- Ethnically relevant product development
Endpoints:
- Melanin production
- Tanning response
- UV protection efficacy
- Biomarker analysis
Above: Pigmented REPROSKIN models respond to UV exposure with increased melanin deposition and formation of protective supranuclear melanin caps. Non-pigmented models show greater signs of UV-induced epidermal damage, demonstrating the biological relevance of the model for pigmentation and photoprotection studies.