The coronary arteries supply blood to the myocardium of the heart and are a key consideration in cardiovascular safety assessment; even small drug-mediated changes in the vascular tone of coronary arteries could increase the risk of angina or myocardial infarction. We are able to assess the potential for drug-mediated effects on human isolated coronary arteries and provide comparisons to coronary arteries from commonly used preclinical species. A few key advantages of our coronary artery model:
- Both IC50 and pA2 values can be determined
- Customized protocols and options to conduct studies to GLP
- A variety of reference compounds available on request (angiotensin II, 8-arginine vasopressin, mephedrone, 5-HT)
- Organ bath or wire myograph studies are possible
Image: Isolated coronary arteries in a Petri dish.