Ion Channel Function Assays

If you are interested in investigating ion channel function, our Ussing chamber system can be used to detect changes in channel activity or exchange mechanisms. By measuring short circuit current (Isc, µAmps), we can predict the effect of your test articles on ion channel function in gastrointestinal tissues, where ion channels play a large role in regulating fluid secretion.

  • Compounds are tested in duplicate at six concentrations
  • Various regions of the gastrointestinal tract are available

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Image: One of our scientists operating an Ussing chamber in our Glasgow laboratory.

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Chloride channel model

This assay uses intestinal mucosa to assess the effects of your test article on chloride channels in the gastrointestinal tract.