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Biopta Publications:

Human Tissue Research and Assays

Following is a list of publications in scientific journals in which REPROCELL Center for Predictive Drug Discovery (formerly Biopta)’s assay services have been made use in. Many of these papers have been authored or co-authored by Biopta staff.


Combining explainable machine learning, demographic and multi-omic data to inform precision medicine strategies for inflammatory bowel disease
Gardiner LJ et al
PLoS One (February 2022)

Dynamising Biomarker R&D with Smarter Biospecimens
Puckrin Z et al
European Biopharmaceutical Review (January 2022)


Human Fresh Tissues VS Clinical Attrition
Macluskie G et al
European Biopharmaceutical Review (July 2021)


Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction
Danahay H et al
FASEB BioAdvances (16 June 2020)
DOI: 10.1096/fba.2020-00035

Retained Functionality of Atherosclerotic Human Arteries Following Photoactivated Linking of the Extracellular Matrix by Natural Vascular Scaffolding Treatment
Ansari E et al
Journal of Cardiovascular Translational Research (2020)
DOI: 10.1007/s12265-020-10063-y


Application of Pharmacogenomics and Bioinformatics to Exemplify the Utility of Human ex vivo Organoculture Models in the Field of Precision Medicine
Cowan K et al
PLOS ONE (2019)
DOI: 10.1371/journal.pone.0226564

Bioengineering the microanatomy of human skin
Roger M et al
Journal of Anatomy 234:4 (2019)
DOI: 10.1111/joa.12942 

Clinical Implications and Translation of an Off-Target Pharmacology Profiling Hit: Adenosine Uptake Inhibition In Vitro
Amouzadeh HR et al
Translational Oncology 12:10 (2019)
DOI: 10.1016/j.tranon.2019.05.018

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways
Miner K et al
Frontiers in Pharmacology 10:51 (2019)
DOI: 10.3389/fphar.2019.00051


Mechanistic Investigations of Diarrhea Toxicity Induced by anti-HER2/3 Combination Therapy
Moisan A et al
Molecular Cancer Therapies 17:7 (2018)
DOI: 10.1158/1535-7163

Nonclinical Cardiovascular Studies of Prucalopride, a Highly Selective 5-Hydroxytryptamine 4 Receptor Agonist
Conlon K et al
The Journal of Pharmacology and Experimental Therapeutics 364:156–169 (2018)
DOI: 10.1124/jpet.117.244079


A New Strategy for Precision Medicine
Bunton D et al
European Biopharmaceutical Review Oct (2017)

Effects of SB204 on LPS-induced Cytokine Release in an Ex Vivo Human Skin Model
McHale et al
Poster Presentation (2017)

Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine
Ahsan K et al
Physiological Reports 5:11 (2017)
DOI: 10.14814/phy2.13299

The Soluble Guanylate Cyclase Stimulator IW-1701 Enhances Nitric Oxide-Mediated Relaxation of Human Lower Esophageal Sphincter Ex Vivo
Zimmer D et al
Gastroenterology 152:5 (2017)
DOI: 10.1016/S0016-5085(17)32443-5

Topical MTX-GNPs reduce IMQ-induced inflammation in mice
Ozcan A et al
Poster Abstract (2017)


Recombinant Human Elastase Alters the Compliance of Atherosclerotic Tibial Arteries After Ex Vivo Angioplasty
Burke S et al
Journal of Cardiovascular Pharmacology 67:4 (2016)
DOI: 10.1097/FJC.0000000000000354

Recombinant Human Elastase Treatment of Cephalic Veins
Wong MD et al
Cardiovascular Pharmacology 5:2 (2016)
DOI: 10.4176/2329-6607.1000178

Studies of human pancreatic elastase treatment of rabbit and human vein rings to predict human therapeutic doses
Burke S et al
Pharmacology Research and Perspectives 4:3 (2016)
DOI: 10.1002/prp2.229


A novel role for CCR3 in promoting airways hyperreactivity; Role for CCR3- muscarinic M3 receptor heterodimers
Bacon K et al
European Respiratory Journal 46 (2015)
DOI: 10.1183/13993003

A Novel Use for Collagen Cross-Linking: Corneal Graft Host/Donor-Bonding
Flavahan P et al
Abstract Submission (2015)

Molecular Profiling of Multiplexed Gene Markers to Assess Viability of Ex Vivo Human Colon Explant Cultures
Drew JE et al
BioResearch 4:1 (2015)
DOI: 10.1089/biores.2015.0029 


Effects of Recombinant Human Type I Pancreatic Elastase on Human Atherosclerotic Arteries
Burke S et al
Journal of Cardiovascular Pharmacology 64:6 (2014)
DOI: 10.1097/FJC.0000000000000149

Functional Studies with Human Isolated Tissues to Better Predict Clinical Safety and Efficacy
Bunton D 
Human-Based Systems for Translational Research Chapter 2 (2014)
DOI: 10.1039/9781782620136-00017

Linaclotide Induces Endocytosis of the Sodium/Hydrogen Exchanger 3 (NHE3) and Inhibits Sodium Absorption
Ameen N et al
Gastroenterology 146:5 (2014)
DOI: 10.1016/S0016-5085(14)62369-6

Using human blood vessels to determine dose and time-dependent activity of a novel therapy for renal and vascular diseases
Biopta Internal R&D Study (2014)


An in vitro investigation of the cardiovascular effects of the 5-HT(4) receptor selective agonists, velusetrag and TD-8954
Beattie DT et al
Vascular Pharmacology 58:150-6 (2013)
DOI: 10.1016/j.vph.2012.11.002  

Comparison of the Intrinsic Vasorelaxant and Inotropic Effects of the Antiarrhythmic Agents Vernakalant and Flecainide in Human Isolated Vascular and Cardiac Tissues
Lynch JJ et al
Journal of Cardiovasc Pharmacology 61:226–232 (2013)
DOI: 10.1097/FJC.0b013e31827afd29 

The contribution of VEGF signaling to fostamatinib-induced blood pressure elevation
Skinner, M et al.
British Journal Pharmacology 171:9 (2013)
DOI: 10.1111/bph.12559

Tumor stromal architecture can define the intrinsic tumor response to VEGF-targeted therapy
Smith NR et al
Clinical Cancer Research 19:24 (2013)


An Antibody Targeted to VEGFR-2 Ig Domains 4-7 Inhibits VEGFR-2 Activation and VEGFR-2-Dependent Angiogenesis without Affecting Ligand Binding
Kendrew J et al
Molecular Cancer Therapeutics 10:770-783 (2012)
DOI: 10.1158/1535-7163.MCT-10-0876

Effects of PRT-201, a Recombinant Human Type I Pancreatic Elastase Treatment on the Elastin Content and Compliance of Atherosclerotic Tibial Arteries Using a Perfusion Myograph
Burke S et al
Journal of the American College of Cardiology 60:17 (2012)
DOI: 10.1016/j.jacc.2012.08.180


Discovery of N-(3-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) 2 thiophene-2-carboximidamide as a Selective Inhibitor of Human 3 Neuronal Nitric Oxide Synthase (nNOS) for the Treatment of Pain
Subhash CA et al
Journal of Medicinal Chemistry 12:34 (2011)
DOI: 10.1021/jm201063u

Humanised Studies
Bunton D et al
European Pharmaceutical Contractor (2011)

The inability of tegaserod to affect platelet aggregation and coronary artery tone at supratherapeutic concentrations
Higgins et al
Naunyn-Schmiedeberg's Archives of Pharmacology 385:1 (2011)
DOI: 10.1007/s00210-011-0687-x 

The use of functional human tissues in drug development
Bunton D
Cell Tissue Bank 12:1 (2011)
DOI: 10.1007/s10561-010-9213-5


A Novel System for the Investigation of Microvascular Dysfunction including Vascular Permeability and Flow Mediated Dilation in Pressurised Human Arteries
Moss E et al
Pharmacological and Toxicological Methods 62: 40-46 (2010)
DOI: 10.1016/j.vascn.2010.04.008

Investigation of the Endocannabinoid System in GI Inflammation and Cancer
Vase HF et al
Poster Presentation (2010)

Novel Therapeutics Targeting the Endocannabinoid System in GI Inflammation and Cancer
Vase HF et al
Poster Presentation (2010) 


A Novel Method for Investigating Vascular Leakage in Pressurized Human Vessels
Moss E et al
Biopta Internal R&D Study (2009)

Could Fresh Human Tissues Play a Key Role in Drug Development?
Hillier C et al
Alternatives to Laboratory Animals 37:1 (2009)
DOI: 10.1177/026119290903701S06

Effects of Inhibition of PDE2 in human and Canine Isolated Subcutaneous Arteries
Bunton D et al
Biopta Internal R&D Study (2009)

New Frontiers for Opioid Drugs
Bunton D et al
European Biopharmaceutical Review (2009)

Topical application of anti-inflammatory compounds in an ex vivo human skin inflammation model
Moss E et al
Biopta internal study (2009) 


Endothelium-dependent differences in 5HT responses in canine mesenteric and coronary arteries
Rankin L et al
Fundamental & Clinical Pharmacology 22:81-91 (2008)

Evaluation of Equine Laminar Vein Function: Harvesting, dissection and the use of functional methods to distinguish between veins and arteries
Keen JA et al
Journal of Pharmacological and Toxicological Methods 57:92-99 (2008)
DOI: 10.1016/j.vascn.2007.10.005

Thrombin-induced Increases in Vascular Permeability in Pressurised Human Arteries: a Novel Optical Method for Isolated Tissues
Moss E et al
Biopta Internal R&D Study (2008) 


Functional human tissue assays
Hillier C et al
Drug Discovery Today 12:382-388 (2007) 

Emerging Frontiers of Designed Multiple Ligands. Rationale Design of Dual Action Nitric Oxide Synthase Inhibitors with 5HT Agonism for the Treatment of Migraine
Maddaford S et al
Canadian Chemistry Conference Poster Presentation (2007) 


The Clinical Relevance of Adrenomedullin: A Promising Profile?
Bunton D et al
Pharmacology and Therapeutics 103: 179-201 (2004)
DOI: 10.1016/j.pharmthera.2004.07.002 


Relaxation to Bradykinin in Bovine Pulmonary Supernumerary Arteries can be mediated by both a Nitric Oxide-Dependent and –Independent Mechanism
Tracey A et al
British Journal of Pharmacology 137: 538-544 (2002) 


5-hydroxytryptamine- and U46619-Mediated Vasoconstriction in Bovine Pulmonary Conventional and Super-Numerary Arteries: Effect of Endogenous Nitric Oxide
Bunton D et al
Clinical Science 98:81-89 (2000)

Regulation of Sensitivity to 5-hydroxytryptamine in Pulmonary Supernumerary but not Conventional Arteries by a 5HT1D- like Receptor
Shaw A et al
European Journal of Pharmacology 408:1 (2000)
DOI: 10.1016/S0014-2999(00)00757-3 


V-shaped cushion at the origin of bovine pulmonary supernumerary arteries: structure and putative function
Shaw A et al
Journal of Applied Physiology 87:6 (1999)
DOI: 10.1152/jappl.1999.87.6.2348