Alvetex Publications: 3D Cell Culture

An extramedullary bone model to study metastatic dormancy reveals a piecemeal model for metastatic reactivation.

Ilaria Malanchi, Stefania Di Blasio, Tatiana Rizou, Laurie Gay, Nicolas Rabas, Probir Chakravarty, Thomas Snoeks, Adam Karoutas, Felipe Rodrigues, Victoria Bridgeman, Xuanxuan Fan, Dominique Bonnet, Ander Abarrategi
Research Square
27 July 2023
DOI: 10.21203/rs.3.rs-3173228/v1

Evaluation of rainbow trout (Oncorhynchus mykiss) organotypic intestinal platforms: cellular responses after long-term exposure to in vitro digested feed

Nicole Verdile, Federica Camin, Marcelo A. Chacon, Rolando Pasquariello, Radmila Pavlovic, David Peggs, Ramon Fontanillas, Amos Tandler, Trond M. Kortner, Amir Bitan, Tiziana A. Brevini and Fulvio Gandolfi
Front. Mar. Sci.
7 July 2023
DOI: 10.3389/fmars.2023.1239682

A novel study of melatonin diffusion in a 3-D cell culture model

Francisco Artime-Naveda, Lucas Alves-Pérez, David Hevia, Sergio Alcón-Rodríguez, Sheila Fernández-Vega, Alejandro Alvarez-Artime, Isabel QuirósGonzález, Rafael Cernuda, Rosa María Sainz, Juan Carlos Mayo
Melatonin Research
13 June 2023
DOI: 10.32794/mr112500148

The NF–Y splicing signature controls hybrid EMT and ECM-related pathways to promote aggressiveness of colon cancer

Giovanna Rigillo, Silvia Belluti, Virginia Campani, Gregorio Ragazzini, Mirko Ronzio, Giacomo Miserocchi, Beatrice Bighi, Laura Cuoghi, Valentina Mularoni, Vincenzo Zappavigna, Diletta Dolfini, Laura Mercatali, Andrea Alessandrini, Carol Imbriano
Cancer Letters
10 June 2023
DOI: 10.1016/j.canlet.2023.216262

Cruciferous vegetable-derived indole-3-carbinol prevents coronavirus cell egression mechanisms in tracheal and intestinal 3D in vitro models.

Georgia Pennarossa, Sharon Arcuri, Rolando Pasquariello, Fulvio Gandolfi, Margherita Maranesi, Tiziana A.L. Brevini
Phytochemistry
12 May 2023
DOI: 10.1016/j.phytochem.2023.113713

Generation of a novel three-dimensional scaffold-based model of the bovine endometrium

MC. Díez, S. Przyborski, A. del Cerro, M. Alonso-Guervós, T. Iglesias-Cabo, S. Carrocera, MA. García, M. Fernández, L. Alonso & M. Muñoz
Veterinary Research Communications
8 May 2023
DOI: 10.1007/s11259-023-10130-0

Exploitation of In Vivo-Emulated In Vitro System in Advanced Food Science

Yonglu Li, Ping Li, Xin Yu, Xiaodong Zheng, and Qing Gu
J Agric Food Chem
6 April 2023
DOI: 10.1021/acs.jafc.2c07289

Safety of Gold Nanoparticles: From In Vitro to In Vivo Testing Array Checklist

Joana Lopes, Tânia Ferreira-Gonçalves, Lia Ascensão, Ana S. Viana, Lina Carvalho, José Catarino, Pedro Faísca, Abel Oliva, Dragana P. C. de Barros, Cecília M. P. Rodrigues, Maria Manuela Gaspar and Catarina Pinto Reis
J Pharmaceutics
31 March 2023
DOI: 10.3390/pharmaceutics15041120

Type I interferon-dependent IFIT3 signaling is critical for viral clearance in airway neutrophils

Amit Gaggar, Camilla Margaroli, Timothy Fram, Nirmal Sharma, Siddharth Patel, Jennifer Tipper, Sarah Robison, Derek Russell, Seth Fortmann, Mudassir Banday, Tarek Abdalla, Sawanan Saitornuang, Matthew Madison, Sixto Leal, Kevin Harrod, Nathaniel Erdmann
Research Square
21 March 2023
DOI: 10.21203/rs.3.rs-1812836/v1 (pre-print)

Abstract: Neutrophilic inflammation characterizes several respiratory viral infections including COVID-19-related ARDS, although its contribution to disease pathogenesis remains poorly understood. Here, we identified two neutrophil subpopulations (A1 and A2) in the airway compartment of 52 severe COVID-19 subjects, where loss of the A2 subset correlated with increased viral burden and reduced 30-days survival. A2 neutrophils showcased a discrete antiviral response with an increased interferon signature. Blockade of type I interferon attenuated viral clearance in A2 neutrophils and downregulated IFIT3 and key catabolic genes, demonstrating direct antiviral neutrophil function. Knockdown of IFIT3 in A2 neutrophils led to loss of IRF3 phosphorylation with consequent reduced viral catabolism, providing the first discrete mechanism of type I interferon signaling in neutrophils. The identification of this novel neutrophil phenotype and its association with severe COVID-19 outcomes emphasizes its likely importance in other respiratory viral infections and potential for new therapeutic approaches in viral illness.

Regulation of epidermal proliferation and hair follicle cycling by synthetic photostable retinoid EC23

Arto Määttä, Rebecca Nixon, Neil Robinson, Carrie A Ambler, Kirsty Goncalves, Victoria Maltman, Stefan Przyborski
J Cosmet Dermatol
03 January 2023
DOI: 10.1111/jocd.15629

The interaction of β-arrestin1 with talin1 driven by endothelin A receptor as a feature of α5β1 integrin activation in high-grade serous ovarian cancer

Ilenia Masi, Flavia Ottavi, Danila Del Rio, Valentina Caprara, Cristina Vastarelli, Sara Maria Giannitelli, Giulia Fianco, Pamela Mozetic, Marianna Buttarelli, Gabriella Ferrandina, Giovanni Scambia, Daniela Gallo, Alberto Rainer, Anna Bagnato, Francesca Spadaro & Laura Rosanò
Cell Death & Disease
30 January 2023
DOI: 10.1038/s41419-023-05612-7

Biomaterial-based in vitro 3D modeling of glioblastoma multiforme

TanvirAhmed
Cancer Pathogenesis and Therapy
9 January 2023
DOI: 10.1016/j.cpt.2023.01.002

Development of a mammalian neurosensory full-thickness skin equivalent and its application to screen sensitizing stimuli

Freer M, Darling N, Goncalves K, Mills KJ, Przyborski S.
Bioeng Transl Med
January 2023
DOI: 10.1002/btm2.10484

2D and 3D cultured human umbilical cord-derived mesenchymal stem cell-conditioned medium has a dual effect in type 1 diabetes model in rats: immunomodulation and beta-cell regeneration

Basak Isildar, Serbay Ozkan, Merve Ercin, Selda Gezginci-Oktayoglu, Mahmut Oncul & Meral Koyuturk
Inflammation and Regeneration
30 November 2022
DOI: 10.1186/s41232-022-00241-7

Application of biomimetic surfaces and 3D culture technology to study the role of extracellular matrix interactions in neurite outgrowth and inhibition

K.E.Goncalves, S.Phillips, D.S.H.Shah, D.Athey, S.A.Przyborski
Biomaterials Advances
23 November 2022
DOI: 10.1016/j.bioadv.2022.213204

Investigation into the effect of skin tone modulators and exogenous stress on skin pigmentation utilizing a novel bioengineered skin equivalent

Kirsty Goncalves, Paola De Los Santos Gomez, Lydia Costello, Lucy Smith, Hugh Mead, Amy Simpson, Stefan Przyborski
Bioengineering and Translational Medicine
26 September 2022
DOI: 10.1002/btm2.10415

Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth

Anna Perdrix Rosell, Oscar Maiques, Joshua Alexander James Martin, Probir Chakravarty, Luigi Ombrato, Victoria Sanz-Moreno, Ilaria Malanchi
Cancer Letters
28 September 2022
DOI: 10.1016/j.canlet.2022.215800

Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease

Camilla Margaroli, Hamed Horati, Luke W.Garratt, Vincent D. Giacalone, Craig Schofield, A. Susanne Dittrich, Tim Rosenow, Brian S.Dobosh, Hong S.Lim, Dario L.Frey, Mieke Veltman, George L.Silva, Milton R.Brown, Carsten Schultz, Harm A.W.M.Tiddens, Sarath Ranganathang, Joshua D.Chandler, Peng Qiu, Limin Peng, Bob J.Scholte, Marcus A.Mall, Anthony Kicic, Lokesh Guglani, Stephen M.Stick, Hettie M.Janssens, Rabindra Tirouvanziam
Journal of Cystic Fibrosis
19 June 2022
DOI: 10.1016/j.jcf.2022.06.001

Modelling liver cancer microenvironment using a novel 3D culture system

Ala’a Al Hrout, Karla Cervantes-Gracia, Richard Chahwan & Amr Amin
Scientific Reports 12, Article number: 8003 (2022)
14 May 2022
DOI: 10.1038/s41598-022-11641-7

Recreating Tissue Structures Representative of Teratomas In Vitro Using a Combination of 3D Cell Culture Technology and Human Embryonic Stem Cells

Alejandro Hidalgo Aguilar, Lucy Smith, Dominic Owens, Rebecca Quelch, and Stefan Przyborski
Bioengineering 2022, 9(5), 185
22 April 2022
DOI: 10.3390/bioengineering9050185

In vitro toxicity of glyphosate in Atlantic salmon evaluated with a 3D hepatocyte-kidney co-culture model

L.Søfteland and P.A.Olsvik
Food and Chemical Toxicology, Volumn 164
14 April 2022
DOI: 10.1016/j.fct.2022.113012

Biomimetic Full-Thickness Skin-on-a-Chip Based on a Fibroblast-Derived Matrix

Patrícia Zoio, Sara Lopes-Ventura, and Abel Oliva
Micro (MDPI)
12 March 2022
DOI: 10.3390/micro2010013

A Novel Coculture System for Assessing Respiratory Sensitizing Potential by IL-4 in T Cells (PDF)

Izuru Mizoguchi, Yasuhiro Katahira, Shinya Inoue, Eri Sakamoto, Aruma Watanabe, Yuma Furusaka, Atsushi Irie, Satoru Senju, Yasuharu Nishimura, Shusaku Mizukami, Kenji Hirayama, Sou Nakamura, Koji Eto, Hideaki Hasegawa and Takayuki Yoshimoto
ALTEX
24 February 2022
DOI: 10.14573/altex.2111181

Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization

Emma Nolan, Victoria Louise Bridgeman, Luigi Ombrato, Adam Karoutas, Nicolas Rabas, Celine Angeli Natascha Sewneth, Marcos Vasquez, Felipe Silva Rodrigues, Stuart Horswell, Peter Faull, Rebecca Carter & Ilaria Malanchi
Nat Cancer 3, 173–187 (2022)
24 February 2022
DOI: 10.1038/s43018-022-00336-7

Neutrophil-derived extracellular vesicles promote feed-forward inflammasome signaling in cystic fibrosis airways

Osric A Forrest, Brian Dobosh, Sarah A Ingersoll, Sanjana Rao, Alexander Rojas, Julie Laval, Jessica A Alvarez, Milton R Brown, Vin Tangpricha, Rabindra Tirouvanziam
J Leuk Biol
16 February 2022
DOI: 10.1002/JLB.3AB0321-149R

Transcriptomic and Functional Evidence Show Similarities between Human Amniotic Epithelial StemCells and Keratinocytes

Li-Ping Liu, Dong-Xu Zheng, Zheng-Fang Xu, Hu-Cheng Zhou, Yun-Cong Wang, Hang Zhou, Jian-Yun Ge, Daisuke Sako, Mi Li, Kazunori Akimoto, Yu-Mei Li, and Yun-Wen Zheng
Cells 2022, 11(1), 70
27 December 2021
DOI: 10.3390/cells11010070

miR-378d suppresses malignant phenotype of ESCC cells through AKT signaling

Jie Peng, Susu Shi, Juan Yu, Jianli Liu, Haixiang Wei, Haixia Song, Shaoqiang Wang, Zhejie Li, Shujin He, Lei Li, Hongyan Zhang, Zhizhen Yan, Ran Zhao, Yukun Liu, Yanrong Liu, Junjun Li, Renya Zhang and Wei Wang
Cancer Cell International volume 21, Article number: 702 (2021)
22 December 2021
DOI: 10.1186/s12935-021-02403-y

Mass production of human airway-like neutrophils via transmigration in an organotypic model of human airways

Brian Dobosh, Vincent D Giacalone, Camilla Margaroli, Rabindra Tirouvanziam
Star Protocols. Volume 2, Issue 4
17 December 2021
DOI: 10.1016/j.xpro.2021.100892

Mechanistic analysis and significance of sphingomyelinasemediated decreases in transepithelial CFTR currents in nHBEs

Kirsten A Cottrill, Vincent D Giacalone, Camilla Margaroli, Robert J Bridges, Michael Koval, Rabindra Tirouvanziam, Nael A McCarty
Physiological Reports.
September 2021
DOI: 10.14814/phy2.15023

Derivation of Adult Human Cortical Organotypic Slice Cultures for Coculture with Reprogrammed Neuronal Cells

Giedre Kvist
Methods in Molecular Biology (MIMB), volume 2352
30 July 2021
DOI: 10.1007/978-1-0716-1601-7_17

Barrier-on-a-Chip with a Modular Architecture and Integrated Sensors for Real-Time Measurement of Biological Barrier Function

Patrícia Zoio, Sara Lopes-Ventura and Abel Oliva
Micromachines 2021, 12(7), 816
12 July 2021
DOI: 10.3390/mi12070816

Pigmented full-thickness human skin model based on a fibroblast-derived matrix for long-term studies

Mrs Patrícia Zoio, Mrs Sara Ventura, Mrs Mafalda Leite, and Dr Abel Oliva
Tissue Engineering Part C: Methods
19 June 2021
DOI: 10.1089/ten.TEC.2021.0069

miR-378d regulates polyploidization and malignant phenotype of tumor cells through AKT and RhoA

Jie Peng, Susu Shi, Juan Yu, Jianli Liu, Haixiang Wei, Haixia Song, Shaoqiang Wang, Daolu Guo, Zhejie Li, Shujin He, Lei Li, Hongyan Zhang, Zhizhen Yan, Ran Zhao, Yukun Liu, Yanrong Liu, Junjun Li, Renya Zhang, Wei Wang
Preprints 2021, 2021060443
16 June 2021
DOI: 10.20944/preprints202106.0443.v1

Immune modulatory effects of Idelalisib in stromal cells of chronic lymphocytic leukemia

Sarah Handl, Franziska von Heydebrand, Simon Voelkl, Robert A J Oostendorp, Jochen Wilke, Anita N Kremer, Andreas Mackensen, and Gloria Lutzny-Geier
Leukemia and Lymphoma
17 May 2021
DOI: 10.1080/10428194.2021.1927019

Using Advanced Cell Culture Techniques to Differentiate Pluripotent Stem Cells and Recreate Tissue Structures Representative of Teratoma Xenografts

L A Smith, A Hidalgo Aguilar, D D G Owens, R H Quelch, E Knight and S A Przyborski
Frontiers in Cell Development and Biology
06 May 2021
DOI: 10.3389/fcell.2021.667246

Extracellular Vesicles From a Three-Dimensional Culture of Perivascular Cells Accelerate Skin Wound Healing in a Rat

Min Ho Kim, Changho Chung, Mun Ho Oh, Jin Hyun Jun, Yong Ko and Jong Hun Lee
Aesthetic Plastic Surgery
05 April 2021
DOI: 10.1007/s00266-021-02254-y

SIRT1 Inhibits Apoptosis by Promoting Autophagic Flux in Human Nucleus Pulposus Cells in the Key Stage of Degeneration via ERK Signal Pathway

Fei He, Qingshu Li, Bo Sheng, Haitao Yang, and Wei Jiang
BioMed Research International, vol. 2021, Article ID 8818713.
DOI: 10.1155/2021/8818713

Use of Porous Polystyrene Scaffolds to Bioengineer Human Epithelial Tissues In Vitro

Costello L, Darling N, Freer M, Bradbury S, Mobbs C, Przyborski S
Methods in Molecular Biology (Clifton, N.J.)
1 January 2021
DOI: 10.1007/978-1-0716-1246-0_20

Generation of Keratinocytes from Human Induced Pluripotent Stem Cells Under Defined Culture Conditions

Shyam Kishor Sah, Jitendra K Kanaujiya, I-Ping Chen, and Ernst J Reichenberger
Cellular Reprogramming
29 December 2020
DOI: 10.1089/cell.2020.0046

The human bone marrow harbors a CD45⁻CD11B⁺ cell progenitor permitting rapid microglia-like cell derivative approaches

Andreas Bruzelius Isabel Hidalgo Antonio Boza-Serrano Anna-Giorgia Hjelmér Amelie Tison Tomas Deierborg Johan Bengzon Tania Ramos-Moreno
Stem Cells Translational Medicine
09 December 2020
DOI: 10.1002/sctm.20-0127

Exposure of the SH-SY5Y Human Neuroblastoma Cells to 50-Hz Magnetic Field: Comparison Between Two-Dimensional (2D) and Three-Dimensional (3D) In Vitro Cultures

Claudia Consales, Alessio Butera, Caterina Merla, Emanuela Pasquali, Vanni Lopresto, Rosanna Pinto, Maria Pierdomenico, Mariateresa Mancuso, Carmela Marino and Barbara Benassi
Molecular Neurobiology
24 November 2020
DOI: 10.1007/s12035-020-02192-x

Developing a novel 3D model of the intestinal epithelium as a tool to study the pharmacokinetics of new chemical entities

Matthew A Freer
Doctoral Thesis, Durham University, UK
25 September 2020

Bioengineering Novel in vitro Co-culture Models That Represent the Human Intestinal Mucosa With Improved Caco-2 Structure and Barrier Function

Nicole J Darling, Claire L Mobbs, Ariana L González-Hau, Matthew Freer and Stefan Przyborski
Frontiers in Bioengineering and Biotechnology
31 August 2020
DOI: 10.3389/fbioe.2020.00992

E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctions

Perla Yaceli Uc, Jael Miranda, Arturo Raya-Sandino, Lourdes Alarcón, María Luisa, Roldán Rodolfo, Ocadiz-Delgado, Enoc Mariano Cortés-Malagón, Bibiana Chávez-Munguía, Georgina Ramírez, René Asomoza, Liora Shoshani, Patricio Gariglio, Lorenza González-Mariscal
International Journal of Oncology
29 July 2020
DOI: 10.3892/ijo.2020.5105

Spheroid Trapping and Calcium Spike Estimation Techniques toward Automation of 3D Culture

Kenneth Ndyabawe, Mark Haidekker, Amish Asthana, William S Kisaalita
SLAS Technology
16 July 2020
DOI: 10.1177/2472630320938319

Grafted human pluripotent stem cell-derived cortical neurons integrate into adult human cortical neural circuitry

Marita Grønning Hansen Cecilia Laterza Sara Palma-Tortosa Giedre Kvist Emanuela Monni Oleg Tsupykov Daniel Tornero Naomi Uoshima Jordi Soriano Johan Bengzon Gianvito Martino Galyna Skibo Olle Lindvall Zaal Kokaia
Stem Cells — Translational Medicine
29 June 2020
DOI: 10.1002/sctm.20-0134

Effect of donor age and 3D-cultivation on osteogenic differentiation capacity of adipose-derived mesenchymal stem cells

Stephan Payr, Tim Schuseil, Marina Unger, Claudine Seeliger, Thomas Tiefenboeck, Elizabeth R Balmayor and Martijn van Griensven
Nature – Scientific Reports 10, Article number: 10408 (2020)
26 June 2020
DOI: 10.1038/s41598-020-67254-5

Recent developments of 3D models of the tumor microenvironment for cutaneous melanoma: Bridging the gap between the bench and the bedside?

Johanna Maria Hölken and Nicole Elisabeth Teusch
Microorganisms Volume 7: 1-7
7 May 2020
DOI: 10.15761/JTS.1000388

Novel 2D and 3D Assays to Determine the Activity of Anti-Leishmanial Drugs

Alec O’Keeffe, Christine Hale, James A. Cotton, Vanessa Yardley, Kapish Gupta, Abhishek Ananthanarayanan, Sudaxshina Murdan, and Simon L Croft
Microorganisms 2020, 8(6), 831
1 June 2020
DOI: 10.3390/microorganisms8060831

Modelling human CNS injury with human neural stem cells in 2- and 3-Dimensional cultures

Barbora Vagaska, Olivia Gillham and Patrizia Ferretti
Scientific Reports 10, Article number: 6785(2020)
22 April 2020
DOI: 10.1038/s41598-020-62906-y

Applications of novel bioreactor technology to enhance the viability and function of cultured cells and tissues

H W Hoyle, L A Smith, R J Williams and S A Przyborski
The Royal Society — Interface Focus
14 February 2020
DOI: 10.1098/rsfs.2019.0090

Apelin Promotes ECM Synthesis by Enhancing Autophagy Flux via TFEB in Human Degenerative NP Cells under Oxidative Stress

Wei Jiang, Pei Zhao, and Xuemei Zhang
Biomed Research Journal
14 February 2020
DOI: 10.1155/2020/4897170

Dataset supporting “Multiple scattering in scanning helium microscopy”

Lambrick S, Vozdecky L, Bergin M, Halpin J E, MacLaren D A, Dastoor P C, Przyborski S A, et al.
University of Cambridge, Apollo Repository
31 January 2020
DOI: 10.17863/CAM.48316

Micropatterning Method for Porous Materials Using the Difference of the Glass Transition Temperature between Exposed and Unexposed Areas of a Thick-Photoresist

Hidetaka Ueno, Kiichi Sato, Kou Yamada and Takaaki Suzuki
Micromachines
2020. 11(1), 54.
DOI: 10.3390/mi11010054

Could 3D models of cancer enhance drug screening?

Virginia Brancato, Joaquim Miguel Oliveira, Vitor Manuel Correlo, Rui Luis Reis, Subhas C.Kunduab
Biomaterials
26 December 2019.
DOI: 10.1016/j.biomaterials.2019.119744

Metastatic-niche labelling reveals parenchymal cells with stem features

Luigi Ombrato, Emma Nolan, Ivana Kurelac, Antranik Mavousian, Victoria Louise Bridgeman, Ivonne Heinze, Probir Chakravarty, Stuart Horswell, Estela Gonzalez-Gualda, Giulia Matacchione, Anne Weston, Joanna Kirkpatrick, Ehab Husain, Valerie Speirs, Lucy Collinson, Alessandro Ori, Joo-Hyeon Lee and Ilaria Malanchi
Nature
volume 572, pages 603-608 (2019)
DOI: 10.1038/s41586-019-1487-6

Emulsion templated scaffolds manufactured from photocurable polycaprolactone

Betül Aldemir Dikici, Colin Sherborne, Gwendolen C.Reilly, Frederik Claeyssens
Science Direct
26 June 2019
DOI: 10.1016/j.polymer.2019.05.023

Engineering a Multilayered Skin Equivalent: The Importance of Endogenous Extracellular Matrix Maturation to Provide Robustness and Reproducibility

Lydia Costello, Nicola Fullard, Mathilde Roger, Steven Bradbury, Teresa Dicolandrea, Robert Isfort, Charles Bascom, Stefan Przyborski
Skin Tissue Engineering
31 May 2019
DOI: 10.1007/978-1-4939-9473-1_9

Osteogenic differentiation of human adipose-derived stem cells in 3D conditions - comparison of spheroids and polystyrene scaffolds

Rumiński S, Kalaszczyńska I, Długosz A, Lewandowska-Szumieł M.
Eur Cell Mater
17 May 2019
DOI: 10.22203/eCM.v037a23

CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer

Letizia Porcelli, Rosa Maria Iacobazzi, Roberta Di Fonte, Simona Serratì, Angelica Intini, Antonio Giovanni Solimando, Oronzo Brunetti, Angela Calabrese, Francesco Leonetti, Amalia Azzariti and Nicola Silvestris
Cancers 2019, 11, 330
7 March 2019
DOI: 10.3390/cancers11030330

Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections

Jocelyn R Grunwell, Vincent D Giacalone, Susan Stephenson, Camilla Margaroli, Brian S Dobosh, Milton R Brown, Anne M Fitzpatrick and Rabindra Tirouvanziam
Nature – Scientific Reports 9, Article number: 2874 (2019)
27 February 2019
DOI: 10.1038/s41598-019-39726-w

Bioengineering the microanatomy of human skin

Mathilde Roger, Nicola Fullard, Lydia Costello, Steven Bradbury, Ewa Markiewicz, Steven O'Reilly, Nicole Darling, Pamela Ritchie, Arto Määttä, Iakowos Karakesisoglou, Glyn Nelson, Thomas von Zglinicki, Teresa Dicolandrea, Robert Isfort, Charles Bascom, Stefan Przyborski
Journal of Anatomy
10 February 2019
DOI: 10.1111/joa.12942

A multifunctional drug nanocarrier for efficient anticancer therapy

Carmen Teijeiro-Valiño, Ramon Novoa-Carballal, Erea Borrajo, Anxo Vidal, Marta Alonso-Nocelo, Maríade la Fuente Freire, Pedro P Lopez-Casas, Manuel Hidalgo, Noémi Csaba, María José Alonso
Journal of Controlled Release.
28 January 2019.
DOI: 10.1016/j.jconrel.2018.12.002

Preparation of 3D porous hydroxyapatite cell scaffolds using polystyrene templates under biomimetic conditions

Kazutoshi IIJIMA, Ayako IIZUKA, Ryo SUZUKI, Hitomi UENO-YOKOHATA3, Nobutaka KIYOKAWA, Mineo HASHIZUME
Journal of the Ceramic Society of Japan 126 [11] 956-958 2018
November 2018
DOI: 10.2109/jcersj2.18144

Glioblastoma’s Next Top Model: novel culture systems for brain cancer radiotherapy research

Seamus P Caragher, Anthony J Chalmers MD/PhD, Natividad Gomez-Roman PhD
Cancers 2018, 2018100697
30 October 2018
DOI: /10.3390/cancers11010044

Regulation of human glioma cell migration, tumor growth, and stemness gene expression using a Lck targeted inhibitor

J P Zepecki, K M Snyder, M M Moreno, E Fajardo, A Fiser, J Ness, A Sarkar, S A Toms and N Tapinos
Oncogene
23 October 2018
DOI: 10.1038/s41388-018-0546-z

Transcription factor programming of human ES cells generates functional neurons expressing both upper and deep layer cortical markers

Giedre Miskinyte, Marita Grønning Hansen, Emanuela Monni, Matti Lam, Johan Bengzon, Olle Lindvall, Henrik Ahlenius, Zaal Kokaia
ACS Omega 2018, 3 (8), pp 10180-10187
11 October 2018
DOI: 10.1371/journal.pone.0204688

Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Electrospun Silica Nonwoven Fabrics

Kazutoshi Iijima, Shohei Ishikawa, Kohei Sasaki, Mineo Hashizume, Masaaki Kawabe, and Hidenori Otsuka
ACS Omega 2018, 3 (8), pp 10180-10187
30 August 2018
DOI: 10.1021/acsomega.8b01139

The tyrosine phosphorylated pro-survival form of Fas intensifies the EGF-induced signal in colorectal cancer cells through the nuclear EGFR/STAT3-mediated pathway

Ngoc Ly Ta, Krittalak Chakrabandhu, Sébastien Huault and Anne-Odile Hueber
Scientific Reports volume 8, Article number: 12424 (2018)
20 August 2018
DOI:10.1038/s41598-018-30804-z

Host-pathogen-interaction reconstituted in 3-dimensional cocultures of mucosa and C. albicans

Mrs Romina Buchs, Mr Bruno Lehner, Dr Phillippe Meuwly, Prof Bruno Schnyder
Tissue Engineering Part C: Methods
14 June 2018
DOI: 10.1089/ten.TEC.2018.0042

Frontline Science: Pathological conditioning of human neutrophils recruited to the airway milieu in cystic fibrosis

Osric A Forrest, Sarah A Ingersoll, Marcela K Preininger, Julie Laval, Dominique H Limoli, Milton R Brown, Frances E Lee, Brahmchetna Bedi, Ruxana T Sadikot, Joanna B Goldberg, Vin Tangpricha, Amit Gaggar, Rabindra Tirouvanziam
Journal of Leukocyte Biology
09 May 2018
DOI: 10.1002/JLB.5HI1117-454RR

Differentiation Patterns of Immortalized Human Meibomian Gland Epithelial Cells in Three-Dimensional Culture

Nagayoshi Asano, Ulrike Hampel, Fabian Garreis, Antje Schröder, Martin Schicht, Christian M Hammer, Friedrich Paulsen
Investigative Ophthalmology and Visual Science, Vol.59, 1343-1353
March 2018
DOI: 10.1167/iovs.17-23266

Development of a microfluidic perfusion 3-dimensional cell culture system

Dong Hyeok Park, Hyeong Jin Jeon, Moon Jeong Kim, Xuan Don Nguyen, Karl Morten and Jeung Sang Go
Journal of Micromechanics and Microengineering
17 January 2018
DOI: 10.1088/1361-6439/aaa877

Substrate Microarchitecture Shapes the Paracrine Crosstalk of Stem Cells with Endothelial Cells and Osteoblasts

Francisco Martín-Saavedra, Lara Crespo, Clara Escudero-Duch, Laura Saldaña, Enrique Gómez-Barrena and Nuria Vilaboa
Scientific Reports 7 Article number: 15182
9 November 2017
DOI: 10.1038/s41598-017-15036-x

Paracrine interactions between mesenchymal stem cells and macrophages are regulated by 1,25-dihydroxyvitamin D3

Laura Saldaña, Gema Vallés, Fátima Bensiamar, Francisco José Mancebo, Eduardo García-Rey and Nuria Vilaboa
Scientific Reports 7, Article number: 14618
3 November 2017
doi:10.1038/s41598-017-15217-8

Effect of_the Scaffold Microenvironment on Cell Polarizability and Capacitance Determined by Probabilistic Computations

Pazmino Betancourt B, Florczyk S, Simon M, Juba D, Douglas JF, Keyrouz W, Bajcsy P, Lee C, Simon CG
Biomedical Materials
26 October 2017
DOI: 10.1088/1748-605X/aa9650

Cale Dobrosak, Jonathan H Gooi
J. Bone Reports
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