Alvetex Publications: 3D Cell Culture

A 3D culture model facilitates mass production of in vitro Plasmodium falciparum haemolymph-like sporozoites

Kiara Hatzakis, Zachary MacMillen, Payton Kirtley, Maya Aleshnick, Thomas Martinson, Priya Gupta, Kristian E. Swearingen, Brandon K. Wilder, James W. Davie, and Marion Avril
Malaria Journal
10 July 2025
DOI: 10.1186/s12936-025-05471-x

Bioengineering a Human Dermal Equivalent Using Induced Pluripotent Stem Cell-Derived Fibroblasts to Support the Formation of a Full-Thickness Skin Construct

Lucy Smith, David Bunton, Michael Finch, and Stefan Przyborski
Cells
8 July 2025
DOI: 10.3390/cells14141044

Engineering a Pigmented Skin Equivalent That Is Responsive to External Stimuli

Paola De Los Santos Gomez, Kirsty Goncalves, Victoria Maltman, Lucy Smith, and Stefan Przyborski
Skin Tissue Engineering
11 April 2025
DOI: 10.1007/978-1-0716-4510-9_9

Engineering a Multilayered Skin Equivalent: The Importance of Endogenous Extracellular Matrix and Model Flexibility for Nuanced and Accurate Skin Studies

Lucy Smith, Victoria Maltman, Paola De Los Santos Gomez, Kirsty Goncalves, and Stefan Przyborski
Skin Tissue Engineering
11 April 2025
DOI: 10.1007/978-1-0716-4510-9_12

New Insights in Microplastic Cellular Uptake Through a Cell-Based Organotypic Rainbow-Trout (Oncorhynchus mykiss) Intestinal Platform

Nicole Verdile, Nico Cattaneo, Federica Camin, Matteo Zarantoniello, Federico Conti, Gloriana Cardinaletti, Tiziana A. L. Brevini, Ike Olivotto, and Fulvio Gandolfi
Cells
3 January 2025
DOI: 10.3390/cells14010044

Gastroesophageal circulating tumor cell crosstalk with peripheral immune system guides CTC survival and proliferation

Tania Rossi, Martina Valgiusti, Maurizio Puccetti, Giacomo Miserocchi, Michele Zanoni, Davide Angeli, Chiara Arienti, Ilaria Pace, Cristian Bassi, Ivan Vannini, Mattia Melloni, Erika Bandini, Milena Urbini, Massimo Negrini, Massimiliano Bonafè, Manuela Ferracin, and Giulia Gallerani
Cell Death, and Disease
29 March 2025
DOI: 10.1038/s41419-025-07530-2

Can Treatment with Human Mesenchymal Stem Cells Rescue the Degenerative Disc Phenotype? An in Vitro Pilot Study of Induced Cytokine Expression

Jonathan Dalton MD, Rajkishen Narayanan MD, Robert J Oris BS, Teeto Ezeonu BA, Evan Bradley BS, Jose A. Canseco MD PhD, Alexander R. Vaccaro MD PhD MBA, John D. Koerner MD, Dessislava Markova PhD, Christopher Kepler MD MBA
The Spine Journal
26 March 2025
DOI: 10.1016/j.spinee.2025.03.026

RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling

Megan A. Palmer, Rebecca Kirchhoff, Claudia Buerger, Yvonne Benatzy, Nils Helge Schebb, and Bernhard Brüne
Cell Death, and Disease
22 January 2025
DOI: 10.1038/s41419-025-07357-x

A Bioengineered Model of the Human Cornea for Preclinical Assessment of Human Ocular Exposure to Environmental Toxicants

Se-jeong Kim, Ning Guo, Zong Yao Tan, Xing Gao, Pouria Fattahi, Haijiao Liu, Jeehan Chang, Mousa Younesi, Selice Jung, Yewhan Chung, Minkyung Song, Michelle Jung, Dan Dongeun Huh
Advanced Healthcare Materials
21 January 2025
DOI: 10.1002/adhm.202402408

Effects of Exosomes from MSC-iPSC on Fibroblasts in vitro in the Presence of Platelet-rich Plasma [PDF]

Andreea (Tibeică) Iordan, C. I. Crețu, S. C. Tibeică, Norina Consuela Forna, M. Costuleanu
Med. Surg. J. – Rev. Med. Chir. Soc. Med. Nat., Iaşi
2024
DOI: 10.22551/MSJ.2024.04.17

Disruption of epithelial barrier integrity via altered GILZ/c-Rel/RACK1 signaling in inflammatory bowel disease (IBD)

Erica Buoso, Mirco Masi, Roberta Valeria Limosani, Francesca Fagiani, Chiara Oliviero, Giorgia Colombo, Luigi Cari, Marco Gentili, Eleonora Lusenti, Lucrezia Rosati, Federica Pisati, Alessandra Pasini, Marco Vincenzo Lenti, Antonio Di Sabatino, Claire Louise Mobbs, Stefan Przyborski, Simona Ronchetti, Cristina Travelli, Marco Racchi
Journal of Crohn's and Colitis
18 Dec 2024
DOI: 10.1093/ecco-jcc/jjae191

Assessing the impact of airborne particulate pollution on human skin utilizing a novel human skin equivalent containing MUTZ-3-derived Langerhans cells

Amy Simpson, Teresa DiColandrea, Stefan Przyborski
Bioengineering and Translational Medicine
13 Dec 2024
DOI: 10.1002/btm2.10738

Comparative analysis of the effects of different hypoxia mimetic agents on the secretome contents of conditioned medium obtained from mesenchymal stem/stromal cells cultured in 2 or 3-dimensional cell culture systems

Serbay Ozkan, Basak Isildar, and Meral Koyuturk
Cytotechnology
7 Dec 2024
DOI: 10.1007/s10616-024-00659-6

Bioengineering the Human Intestinal Mucosa and the Importance of Stromal Support for Pharmacological Evaluation In Vitro

Matthew Freer, Jim Cooper, Kirsty Goncalves, and Stefan Przyborski
Cells
8 Nov 2024
DOI: 10.3390/cells13221859

P13.06. A evaluation of BBB permeable WEE1 and CHK1 inhibitors in combination with standard of care for the treatment of Glioblastoma

E L Scholefield, N Gomez-Roman
Neuro-Oncology
5 Oct 2024
DOI: 10.1093/neuonc/noae144.239

Ank-mediated pyrophosphate regulates shear stress-induced small extracellular vesicle production in 3D-cultured osteocytes

Su Jeong Lee, Deuk Kju Jung, Soomin Im, Changkook You, Jung-Eun Kim, Jong-Sup Bae, Mee-seon Kim, Kyungmoo Yea, and Eui Kyun Park
Animal Cells and Systems
22 Oct 2024
DOI: 10.1080/19768354.2024.2409460

Investigation into the significant role of dermal-epidermal interactions in skin ageing utilising a bioengineered skin construct

Lydia Costello, Kirsty Goncalves, Paola De Los Santos Gomez, Ben Hulette, Teresa Dicolandrea, Michael J. Flagler, Robert Isfort, John Oblong, Charlie Bascom, Stefan Przyborski
Journal of Cellular Physiology
8 Oct 2024
DOI: 10.1002/jcp.31463

Role of mesenchymal stem cell conditioned medium on wound healing using a developed 3D skin model

Moyassar Al-Shaibani, Xiao-nong Wang, Asif Tulah, Rachel E Crossland, Anne M Dickinson, Penny E Lovat
Journal of Wound Care
20 Aug 2024
DOI: 10.12968/jowc.2021.0397

Modulation of the Nogo signaling pathway to overcome amyloid-β-mediated neurite inhibition in human pluripotent stem cell-derived neurites

Kirsty Goncalves, Stefan Przyborski
Neural Regeneration Research
29 July 2024
DOI: 10.4103/NRR.NRR-D-23-01628

Exploring the Surface: Sampling of Potential Skin Cancer Biomarkers Kynurenine and Tryptophan, Studied on 3D Melanocyte and Melanoma Models

Sylwia Hasterok, Skaidre Jankovskaja, Ruzica Miletic Dahlström, Zdenka Prgomet, Lars Ohlsson, Sebastian Björklund, and Anna Gustafsson
Biomolecules
9 July 2024
DOI: 10.3390/biom14070815

Development of human pancreatic cancer avatars as a model for dynamic immune landscape profiling and personalized therapy

Deniel Hughes, Alice Evans, Simei Go, Michael Eyres, Liuliu Pan, Somnath Mukherjee, Zahir Soonawalla, Frances Willenbrock, Eric O’Neill
Science Advances
5 July 2024
DOI: 10.1126/sciadv.adm9071

The β-arrestin1/endothelin axis bolsters ovarian fibroblast-dependent invadosome activity and cancer cell metastatic potential

Danila Del Rio, Ilenia Masi, Valentina Caprara, Flavia Ottavi, Gabriele Albertini Petroni, Erica Salvati, Daniela Trisciuoglio, Sara Maria Giannitelli, Anna Bagnato, Emanuele Mauri, Francesca Spadaro, and Laura Rosanò
Cell Death and Disease
22 May 2024
DOI: 10.1038/s41419-024-06730-6

Cell Senescence-Independent Changes of Human Skin Fibroblasts with Age

Nicola Fullard, James Wordsworth, Ciaran Welsh, Victoria Maltman, Charlie Bascom, Ryan Tasseff, Robert Isfort, Lydia Costello, Rebekah-Louise Scanlan, Stefan Przyborski, and Daryl Shanley
Cells
9 April 2024
DOI: 10.3390/cells13080659

Development of a 3D Brain Model to Study Sex-Specific Neuroinflammation After Hemorrhagic Stroke

Rezwanul Islam, Hadi Hasan Choudhary, Hritik Mehta, Feng Zhang, Tudor G. Jovin, and Khalid A. Hanafy
Translational Stroke Research
16 March 2024
DOI: 10.1007/s12975-024-01243-y

Comparative analysis of effects of conditioned mediums obtained from 2D or 3D cultured mesenchymal stem cells on kidney functions of diabetic rats: Early intervention could potentiate transdifferentiation of parietal epithelial cell into podocyte precursors

Serbay Ozkan, Basak Isildar, Hakan Sahin, Halil Ibrahim Saygi, Dildar Konukoglu, Meral Koyuturk
Life Sciences
11 March 2024
DOI: 10.1016/j.lfs.2024.122543

Development and Optimisation of Tumour Treating Fields (TTFields) Delivery within 3D Primary Glioma Stem Cell-like Models of Spatial Heterogeneity

Callum G. Jones, Aurelie Vanderlinden, Ola Rominiyi, and Spencer J. Collis
Cancers
16 February 2024
DOI: 10.3390/cancers16050863

An in vitro model to study immune activation, epithelial disruption and stromal remodelling in inflammatory bowel disease and fistulising Crohn’s disease

Claire L. Mobbs, Nicole J. Darling and Stefan Przyborski
Frontiers in Immunology
12 February 2024
DOI: 10.3389/fimmu.2024.1357690

BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma

Ana Hipólito, Renato Xavier, Cheila Brito, Ana Tomás, Isabel Lemos, Luís C. Cabaço, Fernanda Silva, Abel Oliva, Duarte C. Barral, João B. Vicente, Luís G. Gonçalves, Marta Pojo, Jacinta Serpa
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
7 Decmber 2023
DOI: 10.1016/j.bbadis.2023.166983

3D human foreskin model for testing topical formulations of sildenafil citrate

Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
International Journal of Pharmaceutics
21 November 2023
DOI: 10.1016/j.ijpharm.2023.123612

Multi-tissue proteogenomic analysis for mechanistic toxicology studies in non-model species

MS Lin, MS Varunjikar, KK Lie, L Søfteland, L Dellafiora, R Ørnsrud, M Sanden, MHG Berntssen, JLCM Dorne, V Bafna, JD Rasinger
Environment International
7 November 2023
DOI: 10.1016/j.envint.2023.108309

Development of an ex vivo porcine skin model for the preclinical evaluation of subcutaneously injected biomacromolecules

Si Gou, Maria Lapteva, Romain Brusini, Killian Flegeau, François Bourdon, Gürkan Kaya, Jimmy Faivre, Yogeshvar N. Kalia
International Journal of Pharmaceutics
30 October 2023
DOI: 10.1016/j.ijpharm.2023.123562

An extramedullary bone model to study metastatic dormancy reveals a piecemeal model for metastatic reactivation.

Ilaria Malanchi, Stefania Di Blasio, Tatiana Rizou, Laurie Gay, Nicolas Rabas, Probir Chakravarty, Thomas Snoeks, Adam Karoutas, Felipe Rodrigues, Victoria Bridgeman, Xuanxuan Fan, Dominique Bonnet, Ander Abarrategi
Research Square
27 July 2023
DOI: 10.21203/rs.3.rs-3173228/v1

Resolvin D1 improves airway inflammation and exercise capacity in cystic fibrosis lung disease

Giulia Ferri, Matteo Serano, Elisa Isopi, Matteo Mucci, Domenico Mattoscio, Romina Pecce, Feliciano Protasi, Marcus A. Mall, Mario Romano, Antonio Recchiuti
FASEB Journal
12 October 2023
DOI: 10.1096/fj.202301495R

Evaluation of rainbow trout (Oncorhynchus mykiss) organotypic intestinal platforms: cellular responses after long-term exposure to in vitro digested feed

Nicole Verdile, Federica Camin, Marcelo A. Chacon, Rolando Pasquariello, Radmila Pavlovic, David Peggs, Ramon Fontanillas, Amos Tandler, Trond M. Kortner, Amir Bitan, Tiziana A. Brevini and Fulvio Gandolfi
Front. Mar. Sci.
7 July 2023
DOI: 10.3389/fmars.2023.1239682

A novel study of melatonin diffusion in a 3-D cell culture model

Francisco Artime-Naveda, Lucas Alves-Pérez, David Hevia, Sergio Alcón-Rodríguez, Sheila Fernández-Vega, Alejandro Alvarez-Artime, Isabel Quirós-González, Rafael Cernuda, Rosa María Sainz, Juan Carlos Mayo
Melatonin Research
13 June 2023
DOI: 10.32794/mr112500148

The NF–Y splicing signature controls hybrid EMT and ECM-related pathways to promote aggressiveness of colon cancer

Giovanna Rigillo, Silvia Belluti, Virginia Campani, Gregorio Ragazzini, Mirko Ronzio, Giacomo Miserocchi, Beatrice Bighi, Laura Cuoghi, Valentina Mularoni, Vincenzo Zappavigna, Diletta Dolfini, Laura Mercatali, Andrea Alessandrini, Carol Imbriano
Cancer Letters
10 June 2023
DOI: 10.1016/j.canlet.2023.216262

Cruciferous vegetable-derived indole-3-carbinol prevents coronavirus cell egression mechanisms in tracheal and intestinal 3D in vitro models.

Georgia Pennarossa, Sharon Arcuri, Rolando Pasquariello, Fulvio Gandolfi, Margherita Maranesi, Tiziana A.L. Brevini
Phytochemistry
12 May 2023
DOI: 10.1016/j.phytochem.2023.113713

Generation of a novel three-dimensional scaffold-based model of the bovine endometrium

MC. Díez, S. Przyborski, A. del Cerro, M. Alonso-Guervós, T. Iglesias-Cabo, S. Carrocera, MA. García, M. Fernández, L. Alonso, and M. Muñoz
Veterinary Research Communications
8 May 2023
DOI: 10.1007/s11259-023-10130-0

Exploitation of In Vivo-Emulated In Vitro System in Advanced Food Science

Yonglu Li, Ping Li, Xin Yu, Xiaodong Zheng, and Qing Gu
J Agric Food Chem
6 April 2023
DOI: 10.1021/acs.jafc.2c07289

Safety of Gold Nanoparticles: From In Vitro to In Vivo Testing Array Checklist

Joana Lopes, Tânia Ferreira-Gonçalves, Lia Ascensão, Ana S. Viana, Lina Carvalho, José Catarino, Pedro Faísca, Abel Oliva, Dragana P. C. de Barros, Cecília M. P. Rodrigues, Maria Manuela Gaspar and Catarina Pinto Reis
J Pharmaceutics
31 March 2023
DOI: 10.3390/pharmaceutics15041120

Type I interferon-dependent IFIT3 signaling is critical for viral clearance in airway neutrophils

Amit Gaggar, Camilla Margaroli, Timothy Fram, Nirmal Sharma, Siddharth Patel, Jennifer Tipper, Sarah Robison, Derek Russell, Seth Fortmann, Mudassir Banday, Tarek Abdalla, Sawanan Saitornuang, Matthew Madison, Sixto Leal, Kevin Harrod, Nathaniel Erdmann
Research Square
21 March 2023
DOI: 10.21203/rs.3.rs-1812836/v1 (pre-print)

Abstract: Neutrophilic inflammation characterizes several respiratory viral infections including COVID-19-related ARDS, although its contribution to disease pathogenesis remains poorly understood. Here, we identified two neutrophil subpopulations (A1 and A2) in the airway compartment of 52 severe COVID-19 subjects, where loss of the A2 subset correlated with increased viral burden and reduced 30-days survival. A2 neutrophils showcased a discrete antiviral response with an increased interferon signature. Blockade of type I interferon attenuated viral clearance in A2 neutrophils and downregulated IFIT3 and key catabolic genes, demonstrating direct antiviral neutrophil function. Knockdown of IFIT3 in A2 neutrophils led to loss of IRF3 phosphorylation with consequent reduced viral catabolism, providing the first discrete mechanism of type I interferon signaling in neutrophils. The identification of this novel neutrophil phenotype and its association with severe COVID-19 outcomes emphasizes its likely importance in other respiratory viral infections and potential for new therapeutic approaches in viral illness.

Regulation of epidermal proliferation and hair follicle cycling by synthetic photostable retinoid EC23

Arto Määttä, Rebecca Nixon, Neil Robinson, Carrie A Ambler, Kirsty Goncalves, Victoria Maltman, Stefan Przyborski
J Cosmet Dermatol
03 January 2023
DOI: 10.1111/jocd.15629

The interaction of β-arrestin1 with talin1 driven by endothelin A receptor as a feature of α5β1 integrin activation in high-grade serous ovarian cancer

Ilenia Masi, Flavia Ottavi, Danila Del Rio, Valentina Caprara, Cristina Vastarelli, Sara Maria Giannitelli, Giulia Fianco, Pamela Mozetic, Marianna Buttarelli, Gabriella Ferrandina, Giovanni Scambia, Daniela Gallo, Alberto Rainer, Anna Bagnato, Francesca Spadaro, and Laura Rosanò
Cell Death, and Disease
30 January 2023
DOI: 10.1038/s41419-023-05612-7

Biomaterial-based in vitro 3D modeling of glioblastoma multiforme

Tanvir Ahmed
Cancer Pathogenesis and Therapy
9 January 2023
DOI: 10.1016/j.cpt.2023.01.002

Development of a mammalian neurosensory full-thickness skin equivalent and its application to screen sensitizing stimuli

Freer M, Darling N, Goncalves K, Mills KJ, Przyborski S.
Bioeng Transl Med
January 2023
DOI: 10.1002/btm2.10484

2D and 3D cultured human umbilical cord-derived mesenchymal stem cell-conditioned medium has a dual effect in type 1 diabetes model in rats: immunomodulation and beta-cell regeneration

Basak Isildar, Serbay Ozkan, Merve Ercin, Selda Gezginci-Oktayoglu, Mahmut Oncul, and Meral Koyuturk
Inflammation and Regeneration
30 November 2022
DOI: 10.1186/s41232-022-00241-7

Application of biomimetic surfaces and 3D culture technology to study the role of extracellular matrix interactions in neurite outgrowth and inhibition

K.E.Goncalves, S.Phillips, D.S.H.Shah, D.Athey, S.A.Przyborski
Biomaterials Advances
23 November 2022
DOI: 10.1016/j.bioadv.2022.213204

Investigation into the effect of skin tone modulators and exogenous stress on skin pigmentation utilizing a novel bioengineered skin equivalent

Kirsty Goncalves, Paola De Los Santos Gomez, Lydia Costello, Lucy Smith, Hugh Mead, Amy Simpson, Stefan Przyborski
Bioengineering and Translational Medicine
26 September 2022
DOI: 10.1002/btm2.10415

Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth

Anna Perdrix Rosell, Oscar Maiques, Joshua Alexander James Martin, Probir Chakravarty, Luigi Ombrato, Victoria Sanz-Moreno, Ilaria Malanchi
Cancer Letters
28 September 2022
DOI: 10.1016/j.canlet.2022.215800

Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease

Camilla Margaroli, Hamed Horati, Luke W.Garratt, Vincent D. Giacalone, Craig Schofield, A. Susanne Dittrich, Tim Rosenow, Brian S.Dobosh, Hong S.Lim, Dario L.Frey, Mieke Veltman, George L.Silva, Milton R.Brown, Carsten Schultz, Harm A.W.M.Tiddens, Sarath Ranganathang, Joshua D.Chandler, Peng Qiu, Limin Peng, Bob J.Scholte, Marcus A.Mall, Anthony Kicic, Lokesh Guglani, Stephen M.Stick, Hettie M.Janssens, Rabindra Tirouvanziam
Journal of Cystic Fibrosis
19 June 2022
DOI: 10.1016/j.jcf.2022.06.001

Modelling liver cancer microenvironment using a novel 3D culture system

Ala’a Al Hrout, Karla Cervantes-Gracia, Richard Chahwan, and Amr Amin
Scientific Reports 12, Article number: 8003 (2022)
14 May 2022
DOI: 10.1038/s41598-022-11641-7

Recreating Tissue Structures Representative of Teratomas In Vitro Using a Combination of 3D Cell Culture Technology and Human Embryonic Stem Cells

Alejandro Hidalgo Aguilar, Lucy Smith, Dominic Owens, Rebecca Quelch, and Stefan Przyborski
Bioengineering 2022, 9(5), 185
22 April 2022
DOI: 10.3390/bioengineering9050185

In vitro toxicity of glyphosate in Atlantic salmon evaluated with a 3D hepatocyte-kidney co-culture model

L.Søfteland and P.A.Olsvik
Food and Chemical Toxicology, Volumn 164
14 April 2022
DOI: 10.1016/j.fct.2022.113012

Biomimetic Full-Thickness Skin-on-a-Chip Based on a Fibroblast-Derived Matrix

Patrícia Zoio, Sara Lopes-Ventura, and Abel Oliva
Micro (MDPI)
12 March 2022
DOI: 10.3390/micro2010013

A Novel Coculture System for Assessing Respiratory Sensitizing Potential by IL-4 in T Cells (PDF)

Izuru Mizoguchi, Yasuhiro Katahira, Shinya Inoue, Eri Sakamoto, Aruma Watanabe, Yuma Furusaka, Atsushi Irie, Satoru Senju, Yasuharu Nishimura, Shusaku Mizukami, Kenji Hirayama, Sou Nakamura, Koji Eto, Hideaki Hasegawa and Takayuki Yoshimoto
ALTEX
24 February 2022
DOI: 10.14573/altex.2111181

Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization

Emma Nolan, Victoria Louise Bridgeman, Luigi Ombrato, Adam Karoutas, Nicolas Rabas, Celine Angeli Natascha Sewneth, Marcos Vasquez, Felipe Silva Rodrigues, Stuart Horswell, Peter Faull, Rebecca Carter, and Ilaria Malanchi
Nat Cancer 3, 173–187 (2022)
24 February 2022
DOI: 10.1038/s43018-022-00336-7

Neutrophil-derived extracellular vesicles promote feed-forward inflammasome signaling in cystic fibrosis airways

Osric A Forrest, Brian Dobosh, Sarah A Ingersoll, Sanjana Rao, Alexander Rojas, Julie Laval, Jessica A Alvarez, Milton R Brown, Vin Tangpricha, Rabindra Tirouvanziam
J Leuk Biol
16 February 2022
DOI: 10.1002/JLB.3AB0321-149R

Transcriptomic and Functional Evidence Show Similarities between Human Amniotic Epithelial StemCells and Keratinocytes

Li-Ping Liu, Dong-Xu Zheng, Zheng-Fang Xu, Hu-Cheng Zhou, Yun-Cong Wang, Hang Zhou, Jian-Yun Ge, Daisuke Sako, Mi Li, Kazunori Akimoto, Yu-Mei Li, and Yun-Wen Zheng
Cells 2022, 11(1), 70
27 December 2021
DOI: 10.3390/cells11010070

miR-378d suppresses malignant phenotype of ESCC cells through AKT signaling

Jie Peng, Susu Shi, Juan Yu, Jianli Liu, Haixiang Wei, Haixia Song, Shaoqiang Wang, Zhejie Li, Shujin He, Lei Li, Hongyan Zhang, Zhizhen Yan, Ran Zhao, Yukun Liu, Yanrong Liu, Junjun Li, Renya Zhang and Wei Wang
Cancer Cell International volume 21, Article number: 702 (2021)
22 December 2021
DOI: 10.1186/s12935-021-02403-y

Mass production of human airway-like neutrophils via transmigration in an organotypic model of human airways

Brian Dobosh, Vincent D Giacalone, Camilla Margaroli, Rabindra Tirouvanziam
Star Protocols. Volume 2, Issue 4
17 December 2021
DOI: 10.1016/j.xpro.2021.100892

Mechanistic analysis and significance of sphingomyelinasemediated decreases in transepithelial CFTR currents in nHBEs

Kirsten A Cottrill, Vincent D Giacalone, Camilla Margaroli, Robert J Bridges, Michael Koval, Rabindra Tirouvanziam, Nael A McCarty
Physiological Reports.
September 2021
DOI: 10.14814/phy2.15023

Derivation of Adult Human Cortical Organotypic Slice Cultures for Coculture with Reprogrammed Neuronal Cells

Giedre Kvist
Methods in Molecular Biology (MIMB), volume 2352
30 July 2021
DOI: 10.1007/978-1-0716-1601-7_17

Barrier-on-a-Chip with a Modular Architecture and Integrated Sensors for Real-Time Measurement of Biological Barrier Function

Patrícia Zoio, Sara Lopes-Ventura and Abel Oliva
Micromachines 2021, 12(7), 816
12 July 2021
DOI: 10.3390/mi12070816

Pigmented full-thickness human skin model based on a fibroblast-derived matrix for long-term studies

Mrs Patrícia Zoio, Mrs Sara Ventura, Mrs Mafalda Leite, and Dr Abel Oliva
Tissue Engineering Part C: Methods
19 June 2021
DOI: 10.1089/ten.TEC.2021.0069

miR-378d regulates polyploidization and malignant phenotype of tumor cells through AKT and RhoA

Jie Peng, Susu Shi, Juan Yu, Jianli Liu, Haixiang Wei, Haixia Song, Shaoqiang Wang, Daolu Guo, Zhejie Li, Shujin He, Lei Li, Hongyan Zhang, Zhizhen Yan, Ran Zhao, Yukun Liu, Yanrong Liu, Junjun Li, Renya Zhang, Wei Wang
Preprints 2021, 2021060443
16 June 2021
DOI: 10.20944/preprints202106.0443.v1

Immune modulatory effects of Idelalisib in stromal cells of chronic lymphocytic leukemia

Sarah Handl, Franziska von Heydebrand, Simon Voelkl, Robert A J Oostendorp, Jochen Wilke, Anita N Kremer, Andreas Mackensen, and Gloria Lutzny-Geier
Leukemia and Lymphoma
17 May 2021
DOI: 10.1080/10428194.2021.1927019

Using Advanced Cell Culture Techniques to Differentiate Pluripotent Stem Cells and Recreate Tissue Structures Representative of Teratoma Xenografts

L A Smith, A Hidalgo Aguilar, D D G Owens, R H Quelch, E Knight and S A Przyborski
Frontiers in Cell Development and Biology
06 May 2021
DOI: 10.3389/fcell.2021.667246

Extracellular Vesicles From a Three-Dimensional Culture of Perivascular Cells Accelerate Skin Wound Healing in a Rat

Min Ho Kim, Changho Chung, Mun Ho Oh, Jin Hyun Jun, Yong Ko and Jong Hun Lee
Aesthetic Plastic Surgery
05 April 2021
DOI: 10.1007/s00266-021-02254-y

SIRT1 Inhibits Apoptosis by Promoting Autophagic Flux in Human Nucleus Pulposus Cells in the Key Stage of Degeneration via ERK Signal Pathway

Fei He, Qingshu Li, Bo Sheng, Haitao Yang, and Wei Jiang
BioMed Research International, vol. 2021, Article ID 8818713.
DOI: 10.1155/2021/8818713

Use of Porous Polystyrene Scaffolds to Bioengineer Human Epithelial Tissues In Vitro

Costello L, Darling N, Freer M, Bradbury S, Mobbs C, Przyborski S
Methods in Molecular Biology (Clifton, N.J.)
1 January 2021
DOI: 10.1007/978-1-0716-1246-0_20

Generation of Keratinocytes from Human Induced Pluripotent Stem Cells Under Defined Culture Conditions

Shyam Kishor Sah, Jitendra K Kanaujiya, I-Ping Chen, and Ernst J Reichenberger
Cellular Reprogramming
29 December 2020
DOI: 10.1089/cell.2020.0046

The human bone marrow harbors a CD45⁻CD11B⁺ cell progenitor permitting rapid microglia-like cell derivative approaches

Andreas Bruzelius Isabel Hidalgo Antonio Boza-Serrano Anna-Giorgia Hjelmér Amelie Tison Tomas Deierborg Johan Bengzon Tania Ramos-Moreno
Stem Cells Translational Medicine
09 December 2020
DOI: 10.1002/sctm.20-0127

Exposure of the SH-SY5Y Human Neuroblastoma Cells to 50-Hz Magnetic Field: Comparison Between Two-Dimensional (2D) and Three-Dimensional (3D) In Vitro Cultures

Claudia Consales, Alessio Butera, Caterina Merla, Emanuela Pasquali, Vanni Lopresto, Rosanna Pinto, Maria Pierdomenico, Mariateresa Mancuso, Carmela Marino and Barbara Benassi
Molecular Neurobiology
24 November 2020
DOI: 10.1007/s12035-020-02192-x

Developing a novel 3D model of the intestinal epithelium as a tool to study the pharmacokinetics of new chemical entities

Matthew A Freer
Doctoral Thesis, Durham University, UK
25 September 2020

Bioengineering Novel in vitro Co-culture Models That Represent the Human Intestinal Mucosa With Improved Caco-2 Structure and Barrier Function

Nicole J Darling, Claire L Mobbs, Ariana L González-Hau, Matthew Freer and Stefan Przyborski
Frontiers in Bioengineering and Biotechnology
31 August 2020
DOI: 10.3389/fbioe.2020.00992

E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctions

Perla Yaceli Uc, Jael Miranda, Arturo Raya-Sandino, Lourdes Alarcón, María Luisa, Roldán Rodolfo, Ocadiz-Delgado, Enoc Mariano Cortés-Malagón, Bibiana Chávez-Munguía, Georgina Ramírez, René Asomoza, Liora Shoshani, Patricio Gariglio, Lorenza González-Mariscal
International Journal of Oncology
29 July 2020
DOI: 10.3892/ijo.2020.5105

Spheroid Trapping and Calcium Spike Estimation Techniques toward Automation of 3D Culture

Kenneth Ndyabawe, Mark Haidekker, Amish Asthana, William S Kisaalita
SLAS Technology
16 July 2020
DOI: 10.1177/2472630320938319

Grafted human pluripotent stem cell-derived cortical neurons integrate into adult human cortical neural circuitry

Marita Grønning Hansen Cecilia Laterza Sara Palma-Tortosa Giedre Kvist Emanuela Monni Oleg Tsupykov Daniel Tornero Naomi Uoshima Jordi Soriano Johan Bengzon Gianvito Martino Galyna Skibo Olle Lindvall Zaal Kokaia
Stem Cells — Translational Medicine
29 June 2020
DOI: 10.1002/sctm.20-0134

Effect of donor age and 3D-cultivation on osteogenic differentiation capacity of adipose-derived mesenchymal stem cells

Stephan Payr, Tim Schuseil, Marina Unger, Claudine Seeliger, Thomas Tiefenboeck, Elizabeth R Balmayor and Martijn van Griensven
Nature – Scientific Reports 10, Article number: 10408 (2020)
26 June 2020
DOI: 10.1038/s41598-020-67254-5

Recent developments of 3D models of the tumor microenvironment for cutaneous melanoma: Bridging the gap between the bench and the bedside?

Johanna Maria Hölken and Nicole Elisabeth Teusch
Microorganisms Volume 7: 1-7
7 May 2020
DOI: 10.15761/JTS.1000388

Novel 2D and 3D Assays to Determine the Activity of Anti-Leishmanial Drugs

Alec O’Keeffe, Christine Hale, James A. Cotton, Vanessa Yardley, Kapish Gupta, Abhishek Ananthanarayanan, Sudaxshina Murdan, and Simon L Croft
Microorganisms 2020, 8(6), 831
1 June 2020
DOI: 10.3390/microorganisms8060831

Modelling human CNS injury with human neural stem cells in 2- and 3-Dimensional cultures

Barbora Vagaska, Olivia Gillham and Patrizia Ferretti
Scientific Reports 10, Article number: 6785(2020)
22 April 2020
DOI: 10.1038/s41598-020-62906-y

Applications of novel bioreactor technology to enhance the viability and function of cultured cells and tissues

H W Hoyle, L A Smith, R J Williams and S A Przyborski
The Royal Society — Interface Focus
14 February 2020
DOI: 10.1098/rsfs.2019.0090

Apelin Promotes ECM Synthesis by Enhancing Autophagy Flux via TFEB in Human Degenerative NP Cells under Oxidative Stress

Wei Jiang, Pei Zhao, and Xuemei Zhang
Biomed Research Journal
14 February 2020
DOI: 10.1155/2020/4897170

Dataset supporting “Multiple scattering in scanning helium microscopy”

Lambrick S, Vozdecky L, Bergin M, Halpin J E, MacLaren D A, Dastoor P C, Przyborski S A, et al.
University of Cambridge, Apollo Repository
31 January 2020
DOI: 10.17863/CAM.48316

Micropatterning Method for Porous Materials Using the Difference of the Glass Transition Temperature between Exposed and Unexposed Areas of a Thick-Photoresist

Hidetaka Ueno, Kiichi Sato, Kou Yamada and Takaaki Suzuki
Micromachines
2020. 11(1), 54.
DOI: 10.3390/mi11010054

Could 3D models of cancer enhance drug screening?

Virginia Brancato, Joaquim Miguel Oliveira, Vitor Manuel Correlo, Rui Luis Reis, Subhas C.Kunduab
Biomaterials
26 December 2019.
DOI: 10.1016/j.biomaterials.2019.119744

Metastatic-niche labelling reveals parenchymal cells with stem features

Luigi Ombrato, Emma Nolan, Ivana Kurelac, Antranik Mavousian, Victoria Louise Bridgeman, Ivonne Heinze, Probir Chakravarty, Stuart Horswell, Estela Gonzalez-Gualda, Giulia Matacchione, Anne Weston, Joanna Kirkpatrick, Ehab Husain, Valerie Speirs, Lucy Collinson, Alessandro Ori, Joo-Hyeon Lee and Ilaria Malanchi
Nature
volume 572, pages 603-608 (2019)
DOI: 10.1038/s41586-019-1487-6

Emulsion templated scaffolds manufactured from photocurable polycaprolactone

Betül Aldemir Dikici, Colin Sherborne, Gwendolen C.Reilly, Frederik Claeyssens
Science Direct
26 June 2019
DOI: 10.1016/j.polymer.2019.05.023

Engineering a Multilayered Skin Equivalent: The Importance of Endogenous Extracellular Matrix Maturation to Provide Robustness and Reproducibility

Lydia Costello, Nicola Fullard, Mathilde Roger, Steven Bradbury, Teresa Dicolandrea, Robert Isfort, Charles Bascom, Stefan Przyborski
Skin Tissue Engineering
31 May 2019
DOI: 10.1007/978-1-4939-9473-1_9

Osteogenic differentiation of human adipose-derived stem cells in 3D conditions - comparison of spheroids and polystyrene scaffolds

Rumiński S, Kalaszczyńska I, Długosz A, Lewandowska-Szumieł M.
Eur Cell Mater
17 May 2019
DOI: 10.22203/eCM.v037a23

CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer

Letizia Porcelli, Rosa Maria Iacobazzi, Roberta Di Fonte, Simona Serratì, Angelica Intini, Antonio Giovanni Solimando, Oronzo Brunetti, Angela Calabrese, Francesco Leonetti, Amalia Azzariti and Nicola Silvestris
Cancers 2019, 11, 330
7 March 2019
DOI: 10.3390/cancers11030330

Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections

Jocelyn R Grunwell, Vincent D Giacalone, Susan Stephenson, Camilla Margaroli, Brian S Dobosh, Milton R Brown, Anne M Fitzpatrick and Rabindra Tirouvanziam
Nature – Scientific Reports 9, Article number: 2874 (2019)
27 February 2019
DOI: 10.1038/s41598-019-39726-w

Bioengineering the microanatomy of human skin

Mathilde Roger, Nicola Fullard, Lydia Costello, Steven Bradbury, Ewa Markiewicz, Steven O'Reilly, Nicole Darling, Pamela Ritchie, Arto Määttä, Iakowos Karakesisoglou, Glyn Nelson, Thomas von Zglinicki, Teresa Dicolandrea, Robert Isfort, Charles Bascom, Stefan Przyborski
Journal of Anatomy
10 February 2019
DOI: 10.1111/joa.12942

A multifunctional drug nanocarrier for efficient anticancer therapy

Carmen Teijeiro-Valiño, Ramon Novoa-Carballal, Erea Borrajo, Anxo Vidal, Marta Alonso-Nocelo, Maríade la Fuente Freire, Pedro P Lopez-Casas, Manuel Hidalgo, Noémi Csaba, María José Alonso
Journal of Controlled Release.
28 January 2019.
DOI: 10.1016/j.jconrel.2018.12.002

Preparation of 3D porous hydroxyapatite cell scaffolds using polystyrene templates under biomimetic conditions

Kazutoshi IIJIMA, Ayako IIZUKA, Ryo SUZUKI, Hitomi UENO-YOKOHATA3, Nobutaka KIYOKAWA, Mineo HASHIZUME
Journal of the Ceramic Society of Japan 126 [11] 956-958 2018
November 2018
DOI: 10.2109/jcersj2.18144

Glioblastoma’s Next Top Model: novel culture systems for brain cancer radiotherapy research

Seamus P Caragher, Anthony J Chalmers MD/PhD, Natividad Gomez-Roman PhD
Cancers 2018, 2018100697
30 October 2018
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Regulation of human glioma cell migration, tumor growth, and stemness gene expression using a Lck targeted inhibitor

J P Zepecki, K M Snyder, M M Moreno, E Fajardo, A Fiser, J Ness, A Sarkar, S A Toms and N Tapinos
Oncogene
23 October 2018
DOI: 10.1038/s41388-018-0546-z

Transcription factor programming of human ES cells generates functional neurons expressing both upper and deep layer cortical markers

Giedre Miskinyte, Marita Grønning Hansen, Emanuela Monni, Matti Lam, Johan Bengzon, Olle Lindvall, Henrik Ahlenius, Zaal Kokaia
ACS Omega 2018, 3 (8), pp 10180-10187
11 October 2018
DOI: 10.1371/journal.pone.0204688

Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Electrospun Silica Nonwoven Fabrics

Kazutoshi Iijima, Shohei Ishikawa, Kohei Sasaki, Mineo Hashizume, Masaaki Kawabe, and Hidenori Otsuka
ACS Omega 2018, 3 (8), pp 10180-10187
30 August 2018
DOI: 10.1021/acsomega.8b01139

The tyrosine phosphorylated pro-survival form of Fas intensifies the EGF-induced signal in colorectal cancer cells through the nuclear EGFR/STAT3-mediated pathway

Ngoc Ly Ta, Krittalak Chakrabandhu, Sébastien Huault and Anne-Odile Hueber
Scientific Reports volume 8, Article number: 12424 (2018)
20 August 2018
DOI:10.1038/s41598-018-30804-z

Host-pathogen-interaction reconstituted in 3-dimensional cocultures of mucosa and C. albicans

Mrs Romina Buchs, Mr Bruno Lehner, Dr Phillippe Meuwly, Prof Bruno Schnyder
Tissue Engineering Part C: Methods
14 June 2018
DOI: 10.1089/ten.TEC.2018.0042

Frontline Science: Pathological conditioning of human neutrophils recruited to the airway milieu in cystic fibrosis

Osric A Forrest, Sarah A Ingersoll, Marcela K Preininger, Julie Laval, Dominique H Limoli, Milton R Brown, Frances E Lee, Brahmchetna Bedi, Ruxana T Sadikot, Joanna B Goldberg, Vin Tangpricha, Amit Gaggar, Rabindra Tirouvanziam
Journal of Leukocyte Biology
09 May 2018
DOI: 10.1002/JLB.5HI1117-454RR

Differentiation Patterns of Immortalized Human Meibomian Gland Epithelial Cells in Three-Dimensional Culture

Nagayoshi Asano, Ulrike Hampel, Fabian Garreis, Antje Schröder, Martin Schicht, Christian M Hammer, Friedrich Paulsen
Investigative Ophthalmology and Visual Science, Vol.59, 1343-1353
March 2018
DOI: 10.1167/iovs.17-23266

Development of a microfluidic perfusion 3-dimensional cell culture system

Dong Hyeok Park, Hyeong Jin Jeon, Moon Jeong Kim, Xuan Don Nguyen, Karl Morten and Jeung Sang Go
Journal of Micromechanics and Microengineering
17 January 2018
DOI: 10.1088/1361-6439/aaa877

Substrate Microarchitecture Shapes the Paracrine Crosstalk of Stem Cells with Endothelial Cells and Osteoblasts

Francisco Martín-Saavedra, Lara Crespo, Clara Escudero-Duch, Laura Saldaña, Enrique Gómez-Barrena and Nuria Vilaboa
Scientific Reports 7 Article number: 15182
9 November 2017
DOI: 10.1038/s41598-017-15036-x

Paracrine interactions between mesenchymal stem cells and macrophages are regulated by 1,25-dihydroxyvitamin D3

Laura Saldaña, Gema Vallés, Fátima Bensiamar, Francisco José Mancebo, Eduardo García-Rey and Nuria Vilaboa
Scientific Reports 7, Article number: 14618
3 November 2017
doi:10.1038/s41598-017-15217-8

Effect of_the Scaffold Microenvironment on Cell Polarizability and Capacitance Determined by Probabilistic Computations

Pazmino Betancourt B, Florczyk S, Simon M, Juba D, Douglas JF, Keyrouz W, Bajcsy P, Lee C, Simon CG
Biomedical Materials
26 October 2017
DOI: 10.1088/1748-605X/aa9650

Increased sphingosine-1-phosphate production in response to osteocyte mechanotransduction

Cale Dobrosak, Jonathan H Gooi
J. Bone Reports
16 October 2017
DOI: 10.1016/j.bonr.2017.10.002

Revisiting the Road Map of Medullary Thymic Epithelial Cell Differentiation

Michel C, Miller CN, Küchler R, Brors B, Anderson MS, Kyewski B, Pinto S
J Immunol. pii: ji1700203
9 October 2017
doi: 10.4049/jimmunol.1700203

Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein

Ansari N, Ho PW, Crimeen-Irwin B, Poulton IJ, Brunt AR, Forwood MR, Divieti Pajevic P, Gooi JH, Martin TJ, Sims NA
J Bone Miner Res
15 September 2017
DOI: 10.1002/jbmr.3291

A Bioinformatics 3D Cellular Morphotyping Strategy for Assessing Biomaterial Scaffold Niches

S Florczyk, M Simon, D Juba, S Pine, S Sarkar, D Chen, P Baker, S Bodhak, A Cardone, M Brady, P Bajcsy, C G Simon
ACS Biomater Sci Eng
31 August 2017
DOI: 10.1021/acsbiomaterials.7b00473

Galectin-1 from conditioned medium of three-dimensional culture of adipose-derived stem cells accelerates migration and proliferation of human keratinocytes and fibroblasts

MH Kim, WH Wu, JH Choi, JH Kim, JH Jun, Y Ko and JH Lee MD
Wound Repair and Regeneration
30 August 2017
DOI: 10.1111/wrr.12579

SHH signalling mediates astrocyte crosstalk with neurons to confer neuroprotection

Ugbode CI, Smith I, Whalley BJ, Hirst WD, Rattray M
J Neurochem
9 May 2017
doi: 10.1111/jnc.14064

Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells

Niu N, Mercado-Uribe I, Liu J
Oncogene
24 April 2017
DOI: 10.1038/onc.2017.72

Osteocyte secreted factors inhibit skeletal muscle differentiation

Wood CL, Divieti Pajevic P, Gooi JH
Bone Reports. p74-80.
6 June 2017
DOI: 10.1016/j.bonr.2017.02.007

Inhibition of glioblastoma dispersal by the MEK inhibitor PD0325901

Shannon S, Jia D, Entersz I, Beelen P, Yu M, Carcione C, Carcione J, Mahtabfar A, Vaca C, Weaver M, Shreiber D, Zahn JD, Liu L, Lin H, Foty RA
BMC Cancer. 17(1):121.
10 February 2017
doi: 10.1186/s12885-017-3107-x

A robust and reproducible human pluripotent stem cell derived model of neurite outgrowth in a three-dimensional culture system and its application to study neurite inhibition

Clarke KE, Tams DM, Henderson AP, Roger MF, Whiting A, Przyborski SA
Neurochem Int. pii: S0197-0186(16)30507-1
20 December 2016
DOI: 10.1016/j.neuint.2016.12.009

Synthesis of Near-Infrared Fluorescent Two-Photon-Absorbing Fluorenyl Benzothiadiazole and Benzoselenadiazole Derivatives

Sheng Yao, Bosung Kim, Xiling Yue, Maria Y. Colon Gomez, Mykhailo V. Bondar, and Kevin D. Belfield
ACS Omega, 2016, 1 (6), pp 1149-1156
7 December 2016
DOI: 10.1021/acsomega.6b00289

A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses

Natividad Gomez-Roman, Katrina Stevenson, Lesley Gilmour, Graham Hamilton and Anthony J Chalmers
Neuro Oncology
30 August 2016
DOI: 10.1093/neuonc/now164

Bcl-xL is an oncogenic driver in colorectal cancer

Scherr AL, Gdynia G, Salou M, Radhakrishnan P, Duglova K, Heller A, Keim S, Kautz N, Jassowicz A, Elssner C, He YW, Jaeger D, Heikenwalder M, Schneider M, Weber A, Roth W, Schulze-Bergkamen H, Koehler BC
Cell Death Dis. 7(8):e2342
18 August 2016
DOI: 10.1038/cddis.2016.233

The dual role of asporin in breast cancer progression

Simkova D, Kharaishvili G, Korinkova G, Ozdian T, Suchánková-Kleplová T, Soukup T, Krupka M, Galandakova A, Dzubak P, Janikova M, Navratil J, Kahounova Z, Soucek K, Bouchal J
Oncotarget
7 July 2016
DOI: 10.18632/oncotarget.10471

TDP-43 regulates endogenous retrovirus-K viral protein accumulation

Manghera M, Ferguson-Parry J, Douville RN
Neurobiol Dis. 94:226-36
October 2016
DOI: 10.1016/j.nbd.2016.06.017

Influence of Matrices on 3D-Cultured Prostate Cancer Cells’ Drug Response and Expression of Drug-Action Associated Proteins

Edmondson R, Adcock AF, Yang L
Public Library of Science. PloS ONE 11(6):e0158116
28 June 2016
DOI: 10.1371/journal.pone.0158116

Structural Analysis of Three-dimensional Human Neural Tissue derived from Induced Pluripotent Stem Cells

Patrick Terrence Brooks, Mikkel Aabech Rasmussen and Poul Hyttel
J Stem Cell Res Ther 6:4
2016
DOI: 10.4172/2157-7633.1000337

Astrocytes Grown in Alvetex Three Dimensional Scaffolds Retain a Non-reactive Phenotype

Ugbode CI, Hirst WD, Rattray M
Neurochem Res. 41(8):1857-67
21 April 2016
doi: 10.1007/s11064-016-1911-3

3D Reconstruction of the Human Airway Mucosa In Vitro as an Experimental Model to Study NTHi Infections

Pasquale Marrazzo, Silvia Maccari, Annarita Taddei, Luke Bevan, John Telford, Marco Soriani, Alfredo Pezzicoli
Public Library of Science. PLoS ONE
April 21, 2016
DOI: 10.1371/journal.pone.0153985

Comparison of the Osteogenic Potential of Mineral Trioxide Aggregate and Endosequence Root Repair Material in a 3-dimensional Culture System

Rifaey HS, Villa M, Zhu Q, Wang YH, Safavi K, Chen IP
J Endod. 2016 42(5):760-5
16 March 2016
DOI: 10.1016/j.joen.2016.02.001

Preclinical evaluation of the AR inhibitor enzalutamide in triple-negative breast cancer cells

Caiazza F, Murray A, Madden SF, Synnott NC, Ryan EJ, O’Donovan N, Crown J, Duffy MJ
Endocr Relat Cancer. 2016 Apr; 23(4):323-34
1 March 2016
DOI: 10.1530/ERC-16-0068.

Oxygen-sensing scaffolds for 3-dimensional cell and tissue culture

James Jenkins, Ruslan I Dmitriev, Karl Morten, Kieran W McDermott, Dmitri B Papkovsky
Acta Biomaterialia
31 January 2015
DOI: 10.1016/j.actbio.2015.01.032

Novel Three Dimensional Human Endocervix Cultures respond to 28-day hormone treatment

Sevim Yildiz Arslan, Yanni Yu, Joanne E. Burdette, Mary Ellen Pavone, Thomas J Hope, Teresa K Woodruff, J Julie Kim
Endocrinology
30 Jan 2015
DOI: 10.1210/en.2014-1840

Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices

Emma J Davies, Meng Dong, Matthias Gutekunst, Katja Närhi, Hanneke JAA van Zoggel, Sami Blom, Ashwini Nagaraj, Tauno Metsalu, Eva Oswald, Sigrun Erkens-Schulze, Juan A Delgado San Martin, Riku Turkki, Stephen R Wedge, Taija M af Hällström, Julia Schueler, Wytske M van Weerden, Emmy W Verschuren, Simon T Barry, Heiko van der Kuip and John A Hickman
Nature-Scientific Reports 5, Article number: 17187 (2015)
9 December 2015
DOI: 10.1038/srep17187

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Lara Stevanato, Caroline Hicks, John D. Sinden
Journal of Visualized Experiments (98), e52410
12 April 2015
DOI: 10.3791/52410

Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways

Gabriela Martínez-Revollar, Erika Garay, Dolores Martin-Tapia, Porfirio Nava, Miriam Huerta, Esther Lopez-Bayghen, Noemí Meraz-Cruz, José Segovia, Lorenza González-Mariscal
Experimental Cell Research. 339(1) pages 67-80
15 November 2015
DOI: 10.1016/j.yexcr.2015.10.006

Neuronal-glial populations form functional networks in a biocompatible 3D scaffold

Imogen Smith, Marcus Haag, Christopher Ugbode, Daniel Tams, Marcus Rattray, Stefan Przyborski, Angela Bithell, Benjamin J Whalley
J Neuroscience Letters
19 October 2015
DOI: 10.1016/j.neulet.2015.10.044

A Novel Fully Humanized 3D Skin Equivalent to Model Early Melanoma Invasion

David S Hill, Neil D P Robinson, Matthew P Caley, Mei Chen, Edel A O’Toole, Jane L Armstrong, Stefan Przyborski, and Penny E Lovat
Molecular Cancer Therapeutics.
1 September 2015
DOI: 10.1158/1535-7163.MCT-15-0394

Dexamethasone-Mediated Activation of Fibronectin Matrix Assembly Reduces Dispersal of Primary Human Glioblastoma Cells

S Shannon, C Vaca, D Jia, I Entersz, et al.
Public Library of Science. PloS ONE, 2015
18 August 2015
DOI: 10.1371/journal.pone.0135951

A method for the evaluation of thousands of automated 3D stem cell segmentations

Bajcsy P, Simon M, Florczyk SJ, Simon CG Jr, Juba D, Brady MC.
J Microsc. 260(3):363-76
13 August 2015
DOI: 10.1111/jmi.12303

Two and three dimensional graphene substrates to magnify osteogenic differentiation of periodontal ligament stem cells

Han Xie, Tong Cao, José Viana Gomes, Antônio Hélio Castro Neto, Vinicius Rosa
Carbon. Volume 93
November 2015
DOI: 10.1016/j.carbon.2015.05.071

The Wnt-inhibitor Sclerostin is Up-regulated by Mechanical Unloading in Osteocytes in vitro

Jordan M Spatz, Marc N Wein, Jonathan H Gooi, Yili Qu, Jenna L Garr, Shawn Liu, Kevin J Barry, Yuhei Uda, Forest Lai, Christopher Dedic, Mercedes Balcells-Camps, Henry M Kronenberg, Philip Babij, Paola Divieti Pajevic
Journal of Biological Chemistry
7 May 2015
DOI: 10.1074/jbc.M114.628313

Increased survival and exocytosis of toxic primary granules by neutrophils in an in vitro model of Cystic Fibrosis airway disease (INC6P.310)

Osric Forrest, Sarah Ingersoll, Marcela Preininger, Julie Laval, Milton Brown and Rabindra Tirouvanziam
Journal of immunology vol.194 (1 Supplement) 192.12.
1 May 2015

Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple negative breast cancer cells

F Caiazza, P M McGowan, M Mullooly, A Murray, N Synnott, N O’Donovan, L Flanagan, C J Tape, G Murphy, J Crown and M J Duffy
British Journal of Cancer
26 May 2015
DOI: 10.1038/bjc.2015.163

Human neural stem cell-derived cultures in three-dimensional substrates form spontaneously functional neuronal networks

Imogen Smith, Vasco Silveirinha, Jason L Stein, Luis de la Torre-Ubieta, Jonathan A Farrimond, Elizabeth M Williamson and Benjamin J Whalley
Journal of Tissue Engineering and Regenerative Medicine
25 February 2015
DOI: 10.1002/term.2001

Assessing Na⁺/H⁺exchange and cell effector functionality in metastatic breast cancer

Schammim Ray Amith, Jodi Marie Wilkinson, Larry Fliegel
J Biochimie Open. 6. 2 (2016) 16-23
27 January 2015
DOI: 10.1016/j.biopen.2016.01.001

Imaging oxygen in neural cell and tissue models by means of anionic cell-permeable phosphorescent nanoparticles

Ruslan I Dmitriev, Sergey M Borisov, Alina V Kondrashina, Janelle MP Pakan, Ujval Anilkumar, Jochen H M Prehn, Alexander V Zhdanov, Kieran W McDermott, Ingo Klimant, Dmitri B Papkovsky
Cellular and Molecular Life Sciences (2015) 72:367-381
January 2015
DOI: 10.1007/s00018-014-1673-5

Development of positive control tissue for in situ hybridisation using Alvetex scaffolds

Christa MacDonald, David Benjamin Finlay, Anower Jabed, Michelle Glass, E Scott Graham
Journal of Neuroscience Methods
30 December 2014
DOI: 10.1016/j.jneumeth.2014.09.006

Topographical cues regulate the crosstalk between MSCs and macrophages

Gema Vallés, Fátima Bensiamar, Lara Crespo, Manuel Arruebo, Nuria Vilaboa, Laura Saldaña
Biomaterials
October 28, 2014
DOI: 10.1016/j.biomaterials.2014.10.028

Pan-Bcl-2 Inhibitor Obatoclax Delays Cell Cycle Progression and Blocks Migration of Colorectal Cancer Cells

Bruno Christian Koehler, Anna-Lena Scherr, Stephan Lorenz, Christin Elssner, Nicole Kautz, Stefan Welte, Dirk Jaeger, Toni Urbanik, Henning Schulze-Bergkamen
Public Library of Science. Plos ONE 9(9): e106571.
5 September 2014
DOI: 10.1371/journal.pone.0106571

Chondrogenic potential of human articular chondrocytes and skeletal stem cells: A comparative study

Siwei Li, Bram G Sengers, Richard OC Oreffo and Rahul S Tare
Journal of Biomaterials Applications
20 August 2014
DOI: 10.1177/0885328214548604

Morphology and functions of astrocytes cultured on water-repellent fractal tripalmitin surfaces

Wei-wei Hu, Zhe Wang, Shan-shan Zhang, Lei Jiang, Jing Zhang, Xiangnan Zhang, Qun-fang Lei, Hyun-Joo Park, Wen-jun Fang, Zhong Chen
Biomaterials 2014
2 June 2014
DOI: 10.1016/j.biomaterials.2014.05.026

The role of high cell density in the promotion of neuroendocrine transdifferentiation of prostate cancer cells

Zuzana Pernicová, Eva Slabáková, Radek Fedr, Šárka Šimečková, Josef Jaroš, Tereza Suchánková, Jan Bouchal, Gvantsa Kharaishvili, Milan Král, Alois Kozubík and Karel Souček
Molecular Cancer 2014, 13:113
20 May 2014
DOI: 10.1186/1476-4598-13-113

The effects of microRNAs on human neural stem cell differentiation in two- and three-dimensional cultures

Lara Stevanato and John D Sinden
Stem Cell Research and Therapy 2014, 5:49
11 April 2014
DOI: 10.1186/scrt437

Small molecule phosphorescent probes for O₂ imaging in 3D tissue models

Ruslan I Dmitriev, Alina V Kondrashina, Klaus Koren, Ingo Klimant, Alexander V Zhdanov, Janelle MP Pakan, Kieran W McDermott and Dmitri B Papkovsky
Biomaterials Science
28 January 2014
DOI: 10.1039/c3bm60272a

Hanging drop: An in vitro air toxic exposure model using human lung cells in 2D and 3D structures

Faye F Liu, Cheng Peng, Beate I Escher, Emmanuelle Fantino, Cindy Giles, Stephen Were, Lesley Duffy, Jack C. Ng
Journal of Hazardous Materials
15 October 2013
DOI: 10.1016/j.jhazmat.2013.01.027

Beyond Cell Death - Antiapoptotic Bcl-2 Proteins Regulate Migration and Invasion of Colorectal Cancer Cells In Vitro

Bruno Christian Koehler, Anna-Lena Scherr, Stephan Lorenz, Toni Urbanik, Nicole Kautz, Christin Elssner, Stefan Welte, Justo Lorenzo Bermejo, Dirk Jäger, Henning Schulze-Bergkamen
Public Library of Science. PLoS ONE 8(10): e76446
3 October 2013
DOI: 10.1371/journal.pone.0076446

Effect of PEG Surface Conformation on Anticancer Activity and Blood Circulation of Nanoemulsions Loaded with Tocotrienol-Rich Fraction of Palm Oil

Alaadin Alayoubi, Saeed Alqahtani, Amal Kaddoumi, Sami Nazzal
The AAPS Journal
30 August 2013
DOI: 10.1208/s12248-013-9525-z

Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity

Sheena Pinto, Chloé Michela, Hannah Schmidt-Glenewinkel, Nathalie Harder, Karl Rohr, Stefan Wild, Benedikt Brorse, and Bruno Kyewskia
PNAS.
26 August 2013
DOI: 10.1073/pnas.1308311110

Epidermal-like architecture obtained from equine keratinocytes in three-dimensional cultures

Ruchi Sharma, Safia Z Barakzai, Sarah E Taylor, F Xavier Donadeu
Journal of Tissue Engineering and Regenerative Medicine
30 July 2013
DOI: 10.1002/term.1788

Targeting of Beta Adrenergic Receptors Results in Therapeutic Efficacy against Models of Hemangioendothelioma and Angiosarcoma

Jessica M Stiles, Clarissa Amaya, Steven Rains, Dolores Diaz, Robert Pham, James Battiste, Jaime F Modiano, Victor Kokta, Laura E Boucheron, Dianne C Mitchell, Brad A Bryan
Public Library of Science. PLoS ONE 8(3): e60021
28 March 2013
DOI: 10.1371/journal.pone.0060021

Characterization of liver specific functions of upcyte® hepatocytes grown in 3D and co-cultured with upcyte® endothelial cells

Dähn C, Hewitt N, Maltman D, Talas G, Przyborski S, Heinz S, Nörenberg A, Scheller K, Braspenning J
Z Gastroenterol, 2012; 50 - P2_05
2012
DOI: 10.1055/s-0031-1295802

Generation of proliferating human hepatocytes using upcyte® technology: characterisation and applications in induction and cytotoxicity assays

Alexandra Burkard, Caroline Dähn, Stefan Heinz, Anne Zutavern, Vera Sonntag-Buck, Daniel Maltman, Stefan Przyborski, Nicola J. Hewitt, and Joris Braspenning
Xenobiotica
October 2012
DOI: 10.3109/00498254.2012.675093

The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells

Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, McEvoy A, Dinsdale D, Condorelli F, Brandner S, Campanella M, Grose R, Jones C, Salomoni P
Oncogene
23 April 2012
DOI: 10.1038/ocn.2012.111

Rat primary hepatocytes show enhanced performance and sensitivity to acetaminophen during three-dimensional culture on a polystyrene scaffold designed for routine use

Schutte M, Fox B, Baradez M, Devonshire A, Minguez J, Bokhari M, Przyborski S, Marshall D
Assay and Drug Development Technologies
October 2011
DOI: 10.1089/adt.2011.0371

Dysregulated TRK signalling is a therapeutic target in CYLD defective tumours

Rajan N, Elliott R, Clewes O, Mackay A, Reis-Filho JS, Burn J, Langtry J, Sieber-Blum M, Lord CJ, Ashworth A
Oncogene
13 October 2011
DOI: 10.1038/onc.2011.133

Adipose tissue-derived stem cells display a proangiogenic phenotype on 3D scaffolds.

Neofytou EA, Chang E, Patlola B, Joubert LM, Rajadas J, Gambhir SS, Cheng Z, Robbins RC, Beygui RE
Journal Biomedical Materials Research Part A
1 September 2011
DOI: 10.1002/jbm.a.33113

Alvetex: Polystyrene scaffold technology for routine three dimensional cell culture.

Knight E, Murray B, Carnachan R, Przyborski SA
Methods in Molecular Biology (2011), 695, 323-40.
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Validation of reference gene stability for APAP hepatotoxicity studies in different in vitro systems and identification of novel potential toxicity biomarkers

Bridget C Fox, Alison S Devonshire, Maaike E Schutte, Carole A Foy, Jesus Minguez, Stefan Przyborski, Daniel Maltman, Maria Bokhari, Damian Marshall
Toxicology In Vitro, Volume 24, Issue 7, October 2010, Pages 1962-1970
October 2010
doi:10.1016/j.tiv.2010.08.007

Developments in three dimensional cell culture technology aimed at improving the accuracy of in vitro analyses

Maltman D, Przyborski SA
Biochemical Society Transactions (2010), 38(4), 1072-5
August 2010
DOI: 10.1042/BST0381072

Emulsion-templated porous polymers as scaffolds for three dimensional cell culture: effect of synthesis parameters on scaffold formation and homogeneity

Carnachan RJ, Bokhari M, Maatta A, Cameron NR, Przyborski SA

Journal or Materials Chemistry
12 Jul 2007
DOI: 10.1039/B707499A

Culture of HepG2 liver cells on three dimensional polystyrene scaffolds enhances cell structure and function during toxicological challenge

Bokhari M, Carnachan R, Cameron NR, Przyborski SA
Journal of Anatomy (2007), 211, 567-76.
15 August 2007
DOI: 10.1111/j.1469-7580.2007.00778.x

Effect of synthesis parameters on emulsion-templated porous polymer formation and evaluation for 3D cell culture scaffolds

Bokhari M, Carnachan R, Przyborski SA, Cameron NR
Journal of Materials Chemistry (2007), 17, 4088-4094
12 July 2007
DOI: 10.1039/B707499A

Novel cell culture device enabling three-dimensional cell growth and improved cell function

Bokhari M, Carnachan R, Cameron NR, Przyborski, SA
Biochemical and Biophysical Research Communications (2007), 354, 1095-1100
6 January 2007
DOI: 10.1016/j.bbrc.2007.01.105

Tailoring the morphology of emulsion-templated porous polymers

Carnachan RJ, Bokhari M, Przyborski SA, Cameron NR
Soft Matter (2006), 2, 608-616
23 May 2006
DOI: 10.1039/B603211G

Porous polymers by emulsion templating

Barbetta A, Carnachan RJ, Smith KH, Zhao C, Cameron NR, Kataky R, Hayman M, Przyborski SA, Swan M
Macromolecular Symposia, 226, 203-211.
20 June 2005
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Growth of human stem cell-derived neurons on solid three dimensional polymers

Hayman MW, Smith KH, Cameron NR, Przyborski SA
Journal of Biochemical and Biophysical Methods (2005), 62, 231-240
31 March 2005
DOI: 10.1016/j.jbbm.2004.12.001

Enhanced neurite outgrowth by human neurons grown on solid three-dimensional scaffolds

Hayman MW, Smith KH, Cameron NR, Przyborski SA
Biochemical and Biophysical Research Communications (2004), 314, 483-488.
6 February 2004
DOI: 10.1016/j.bbrc.2003.12.135