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Clinical Stem Cell Services

GMP MSC production service for your clinical application

REPROCELL and our experienced partner, Histocell, can help with your next clinical MSC project.

Why MSCs?

Mesenchymal Stem Cells (MSCs), also known as Mesenchymal Stromal Cells, have received a lot of interest, both as direct therapeutic agents and for their potential to differentiate into clinically relevant somatic cell types and tissues. More than 1000 clinical trials using MSCs in a wide variety of therapeutic areas have been reported.

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Use of MSCs for Clinical Projects. MSCs can be isolated from a variety of tissues, including bone marrow, adipose tissue, and cord blood or placenta. These MSCs can be purified and expanded in the laboratory to generate sufficient cells for development of a cell therapy. Expanded MSCs can be differentiated to a variety of tissues for therapeutic applications, including cartilage, muscle, and bone.

MSCs can be isolated from multiple sources and possess the ability for self-renewal and multi-lineage differentiation (above). Further, primary MSCs can migrate toward sites of injury and tumor microenvironments, making them attractive for use as a drug delivery vehicle for targeted therapies.

All factors secreted by MSCs, including paracrine substances and exosomes (extracellular vesicles), can be isolated and harvested. The MSC secretome has been shown to promote immune modulation and tissue modulation during various applications in regenerative medicine therapy.

Also available:

❯ Clinical grade ready-to-use MSCs

❯ Research grade MSCs and products for MSC research

Our CDMO Partner, Histocell

Our GMP projects are performed in collaboration with Histocell, a CDMO and clinical-stage biopharmaceutical company based in Spain. Histocell is registered with the European Medicines Agency (EMA) for manufacturing clinical-grade cell products in compliance with GMP guidelines.

❯ About Histocell – our GMP cell manufacturing partner

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Our MSC-related services

  • Isolation and expansion of autologous or allogeneic adult adipose-derived MSCs
  • Expansion of autologous and allogeneic adult bone marrow MSCs
  • Mesodermal Trilineage differentiation of MSCs (chondrocytes, osteocytes, myocytes)
  • Production and characterization of cell-derived products like secretome and exosomes

We provide all regulatory QC specified by the EMA or FDA, and all the required documentary support for the GMP product.

FAQs

❯ Frequently Asked Questions about Clinical MSCs

We can also help with your Research MSC Project

R&D lab – GMP-like production and QC

  • Fully equipped Molecular biology and cell culture lab including
    • Cytofluorometry
    • Spectrophotometry
    • Immunohistochemistry
  • Suitable for general R&D projects
  • Provides a GMP-like tech-transfer phase
  • Uses Quality Control similar to cell therapy drugs

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Ask our experts about our GMP MSC production service

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