- Clinical Stem Cell Services
- GMP iMSC & MSC Production Service
GMP iMSC & MSC Manufacturing for Cell Therapy
End-to-end GMP manufacturing of iPSC-derived MSCs (iMSCs) and primary MSCs, including cell sourcing, expansion, and Master Cell Bank (MCB) generation.
GMP iMSC Manufacturing
Generate GMP iMSC MCBs from REPROCELL StemRNA™ Clinical iPSC Seed Clones or your own iPSC line.
- GMP iMSC MCB generation
- Scalable iMSC expansion
- Custom manufacturing workflows
- Integration with clinical iPSC and gene-editing services
Primary MSC Manufacturing
Access custom GMP manufacturing for primary MSCs through our European CDMO partner, Histocell.
- Autologous and allogeneic MSC manufacturing
- Adipose- and bone marrow-derived MSCs
- MCB and Working Cell Bank (WCB) generation
- MSC expansion and differentiation
- MSC-derived secretome and exosome production
Ready-to-Use GMP MSCs
Access off-the-shelf GMP bone marrow-derived MSCs through Cellcolabs.
- Healthy, screened donors
- GMP manufactured
- Available for immediate use
- Multiple lots available
Multiple Starting Points
Start with a StemRNA™ Clinical iPSC Clone, your own iPSC line, primary MSCs or sourced donor material.
From iPSC to iMSC MCB
Connect clinical iPSC sourcing, StemEdit Gene Editing, differentiation and GMP iPSC & iMSC MCB Manufacturing – REPROCELL USA through one coordinated development pathway.
USA & Europen GMP Manufacturing
Access GMP iPSC & iMSC MCB Manufacturing – REPROCELL USA, and GMP iPSC & MSC MCB Manufacturing – Histocell (Europe).
Global Regulatory Readiness
Manufacturing processes and quality documentation are designed to support cell therapy programs targeting FDA, EMA, and PMDA regulatory pathways.
Custom &
Off-the-shelf Options
Choose a custom GMP iMSC/MSC manufacturing program or ready-to-use GMP MSCs depending on your development strategy.
REPROCELL USA: Beltsville, Maryland
REPROCELL USA provides GMP-grade iPSC and iMSC MCB manufacturing at our Beltsville, Maryland facility:
- Closed, modular Cytocentric Xvivo system
- Class 100 (ISO 5) containment
- Complete with HEPA‑filtered environment
- Controlled environmental monitoring
The closed manufacturing system helps minimize contamination risk while providing a controlled environment for clinical cell manufacturing.
Histocell: Bilbao, Spain
Through our partnership with Histocell, we provide GMP manufacturing for iPSC and MSC cell therapy programs at its authorized facility in Bilbao, Spain:
- GMP ATMP manufacturing since 2011
- 350+ GMP batches manufactured
- Autologous and allogeneic manufacturing
- MCB and WCB manufacturing and storage
The facility supports flexible manufacturing from preclinical and clinical development toward commercial-scale production.
