Exosomes derived from iPSCs are being actively studied for their unique ability to influence cellular health and regenerative processes. Below are some frequently asked questions about their potential applications, with insights drawn from published scientific research.
Can iPSC exosomes help reduce cellular aging?
Yes. Fibroblasts, the connective tissue cells that produce collagen, tend to stop dividing as they age in long-term culture. This process can be tracked by markers such as β-galactosidase (β-gal). Published studies have shown that when aging fibroblasts are treated with iPSC exosomes, levels of β-gal are reduced. This suggests that iPSC exosomes may help maintain cell vitality and delay cellular senescence. (Ref. 1)
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Can iPSC exosomes protect fibroblasts from UV damage?
Yes. UV exposure can harm fibroblasts by reducing both their numbers and their ability to produce collagen. Studies demonstrate that fibroblasts treated with iPSC exosomes maintain their cell numbers even after 48 hours of UV exposure, highlighting a protective effect against UV-induced cellular damage. (Ref. 1)
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Can iPSC exosomes help maintain vascular structure under stress?
Yes. High blood sugar levels accelerate vascular aging, damaging blood vessel cells and disrupting their integrity. Research indicates that treating vascular cells with iPSC exosomes helps preserve cell numbers and maintain a healthy vascular structure, even under prolonged high-sugar conditions. (Ref. 2)
Can iPSC exosomes support cell proliferation?
Yes. As cells—including stem cells—age, they lose the ability to divide, and their growth slows down with repeated culture. Research demonstrates that treatment with iPSC exosomes can restore this proliferative capacity. Notably, iPSC exosomes have been shown to outperform MSC-derived exosomes in promoting cell growth. (Ref. 2, 3, 4)
