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StemEdit Gene Editing
License-free CRISPR Platform

AI-designed tools for stem cell engineering, hypoimmune cell development 
and translational research

stemedit-ai-gene-editing-platform

StemEdit combines REPROCELL’s clinically aligned StemRNA™ iPSC technology with AI-designed OpenCRISPR-1™ (OC-1) editing tools to enable precise, reproducible, and scalable genome engineering workflows without licensing restrictions. 

Key Benefits 

✓ License-free


✓ Precise Genomic Integration

✓ Translationally Focused

✓High on-target editing efficiency 

OC-1 , licensed from Profluent Bio, forms the foundation of REPROCELL's StemEdit platform. REPROCELL has expanded the platform beyond the core nuclease by developing integrated gene editing products, engineered cell lines, and custom genome engineering services, providing a comprehensive, license-free solution for stem cell research and translational development.

*StemEdit is provided without licensing requirements for the editing platform. Customers remain responsible for ensuring freedom to operate for their specific therapeutic targets and intended commercial applications. 

Find the right solution for your research or
cell therapy development program

StemEdit Services Featured Image Brighter

StemEdit Gene Editing Service
Clinical & Research Projects

Custom gene editing services for iPSCs and mammalian cells including knockouts, knock-ins, multiplex editing, and hypoimmune engineering.

Landing Pad Featured Image Brighter

Landing Pad Technology
Part of StemEdit Service

Precise insertion of therapeutic genes into engineered cells. Reuse an established landing pad to efficiently add or exchange genes, saving time and reducing lab costs.

StemEdit KO lines

StemEdit
B2M & CIITA KO Lines
Research Use

Ready-to-use, hypoimmune iPSC and iMSC lines with B2M and CIITA knockouts. Ideal for allogeneic cell therapy research and off-the-shelf applications.

OC-1 DArker Image

StemEdit
OC-1 Protein
Ready for Your Laboratory

AI-designed OpenCRISPR-1 (OC-1) protein delivers strong editing activity, SpCas9-like on-target performance, and reduced off-target effects.

StemEdit Platform Overview

Gene Editing Services

StemEdit Gene Editing Service is REPROCELL’s AI-designed gene editing platform for advanced stem cell engineering, supporting both research and translational cell therapy applications. Combining StemRNA™ Clinical iPSC Seed Clones with OpenCRISPR-1 (OC-1) technology from Profluent Bio, StemEdit enables high-efficiency genome editing with reduced off-target effects in mammalian cells, including iPSCs, HEK, CHO, and primary cells.

StemEdit OC-1 Protein

REPROCELL also offers StemEdit OC-1 Protein for high-efficiency gene editing directly in your lab. Designed using AI-trained protein language models, OC-1 delivers strong editing activity, SpCas9-like on-target performance, and compatibility with base editing workflows for precise genome engineering applications.

Advanced Cell Engineering

StemEdit supports custom gene editing services, hypoimmune cell engineering, and Landing Pad Technology, a modular platform for precise, reproducible insertion or exchange of therapeutic genes. REPROCELL also offers ready-to-use StemEdit B2M & CIITA knockout hypoimmune iPSCs and iPSC-derived mesenchymal stem cells (iMSCs) designed for allogeneic cell therapy and regenerative medicine research.

Supported Applications

  • Hypoimmune cell engineering

  • B2M and CIITA knockout generation

  • Custom iPSC engineering

  • Landing Pad integration

  • Therapeutic transgene insertion

 

  • Disease model development

  • Regenerative medicine research

  • Allogeneic cell therapy workflows

  • Stem cell engineering

  • Translational genome editing

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