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StemEdit Gene Editing
AI-designed gene editing tools and services for stem cell engineering, hypoimmune iPSC development, and translational research. 

StemEdit combines REPROCELL’s clinically aligned StemRNA™ iPSC technology with OpenCRISPR-1™ (OC-1), an AI-designed genome editing nuclease licensed from Profluent Bio, to enable precise, reproducible, and scalable genome engineering.

Building on OC-1, REPROCELL has developed an integrated platform of gene editing products, engineered iPSC lines, and custom genome editing services for stem cell research and translational development.

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Find the right solution for your program

Explore gene editing services, engineered cell lines and genome editing tools for research and
translational development.

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StemEdit Gene Editing Service 


Clinical & Research Projects

Custom gene editing services for iPSCs and mammalian cells including knockouts, knock-ins, multiplex editing, and hypoimmune engineering.

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Landing Pad
Technology


Part of StemEdit Service

Precise insertion of therapeutic genes into engineered cells. Reuse an established landing pad to efficiently add or exchange genes, saving time and reducing lab costs.

StemEdit KO lines

StemEdit
B2M & CIITA KO Lines


Research Use

Ready-to-use, hypoimmune iPSC and iMSC lines with B2M and CIITA knockouts. Ideal for allogeneic cell therapy research and off-the-shelf applications.

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StemEdit
OC-1 Protein


Ready for Your Laboratory

AI-designed OpenCRISPR-1 (OC-1) protein delivers strong editing activity, SpCas9-like on-target performance, and reduced off-target effects.

Key Benefits

✓

License-Included
Gene Editing Service & Hypoimmune Cell Lines

✓

Precise Genomic Integration

✓

Translationally Focused

✓

High on-target editing efficiency

Supported Applications

Cell & Genome Engineering

  • Hypoimmune cell engineering

  • B2M and CIITA knockout generation

  • Custom iPSC engineering

  • Landing Pad integration

  • Therapeutic transgene insertion 

 

Research & Translational Applications

  • Disease model development

  • Allogeneic cell therapy workflows

  • Translational genome editing 

StemEdit Licensing 

StemEdit products and services are offered under different licensing frameworks.

StemEdit Hypoimmune iPSCs &
Gene Editing Services

✓ License included
Research • Clinical • Commercial

The applicable license for research, clinical, and commercial use is included with eligible off-the-shelf Hypoimmune iPSC lines and StemEdit Gene Editing Services. No separate or additional license is required, subject to the applicable terms of use and service agreement.

StemEdit OC-1 Protein

! Separate commercial license required
Research & GMP formats available

StemEdit OC-1 Protein is available in Research and GMP formats. Commercial use requires a separate commercial-use agreement with Profluent Bio. Please contact REPROCELL for further information.

Please note: Users remain responsible for ensuring compliance with applicable third-party intellectual property covering guide RNAs, delivery methods, and downstream applications.

Related StemEdit Resources

StemEdit Pages

Featured Webinar

Watch video on YouTube

Webinar: HypoImmune iPS Cell Engineering and Genome Modification

Dr Yongming Luke Ren
Stem Cell Scientist, REPROCELL, Beltsville, MD

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StemEdit License-Free Gene Editing Solutions

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