StemEdit Gene Editing
License-free CRISPR Platform
AI-designed tools for stem cell engineering, hypoimmune cell development and translational research
AI-designed tools for stem cell engineering, hypoimmune cell development and translational research

StemEdit combines REPROCELL’s clinically aligned StemRNA™ iPSC technology with AI-designed OpenCRISPR-1™ (OC-1) editing tools to enable precise, reproducible, and scalable genome engineering workflows without licensing restrictions.
License-free
Precise Genomic Integration
Translationally Focused
High on-target editing efficiency
OC-1, licensed from Profluent Bio, forms the foundation of REPROCELL's StemEdit platform. REPROCELL has expanded the platform beyond the core nuclease by developing integrated gene editing products, engineered cell lines, and custom genome engineering services, providing a comprehensive, license-free solution for stem cell research and translational development.
*StemEdit is provided without licensing requirements for the editing platform. Customers remain responsible for ensuring freedom to operate for their specific therapeutic targets and intended commercial applications.

Clinical & Research Projects
Custom gene editing services for iPSCs and mammalian cells including knockouts, knock-ins, multiplex editing, and hypoimmune engineering.

Part of StemEdit Service
Precise insertion of therapeutic genes into engineered cells. Reuse an established landing pad to efficiently add or exchange genes, saving time and reducing lab costs.

Research Use
Ready-to-use, hypoimmune iPSC and iMSC lines with B2M and CIITA knockouts. Ideal for allogeneic cell therapy research and off-the-shelf applications.

Ready for Your Laboratory
AI-designed OpenCRISPR-1 (OC-1) protein delivers strong editing activity, SpCas9-like on-target performance, and reduced off-target effects.
StemEdit Gene Editing Service is REPROCELL’s AI-designed gene editing platform for advanced stem cell engineering, supporting both research and translational cell therapy applications. Combining StemRNA™ Clinical iPSC Seed Clones with OpenCRISPR-1 (OC-1) technology from Profluent Bio, StemEdit enables high-efficiency genome editing with reduced off-target effects in mammalian cells, including iPSCs, HEK, CHO, and primary cells.
REPROCELL also offers StemEdit OC-1 Protein for high-efficiency gene editing directly in your lab. Designed using AI-trained protein language models, OC-1 delivers strong editing activity, SpCas9-like on-target performance, and compatibility with base editing workflows for precise genome engineering applications.
StemEdit supports custom gene editing services, hypoimmune cell engineering, and Landing Pad Technology, a modular platform for precise, reproducible insertion or exchange of therapeutic genes. REPROCELL also offers ready-to-use StemEdit B2M & CIITA knockout hypoimmune iPSCs and iPSC-derived mesenchymal stem cells (iMSCs) designed for allogeneic cell therapy and regenerative medicine research.
Hypoimmune cell engineering
B2M and CIITA knockout generation
Custom iPSC engineering
Landing Pad integration
Therapeutic transgene insertion
Disease model development
Regenerative medicine research
Allogeneic cell therapy workflows
Stem cell engineering
Translational genome editing
Webinar: HypoImmune iPS Cell Engineering and Genome Modification
Dr Yongming Luke Ren
Stem Cell Scientist, REPROCELL, Beltsville, MD
StemEdit License-Free Gene Editing Solutions
Resource
Webinar
Resources
Latest in Gene Editing
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Discover the innovative StemEdit OC-1 Protein, a generative AI-designed gene-editing enzyme that enhances genome engineering with improved safety and efficiency.
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AI-Designed CRISPR Enables Hypoimmune iPSC Engineering for Off-the-Shelf Cell Therapy
REPROCELL's StemEdit platform enables the creation of hypoimmune iPSCs for scalable off-the-shelf cell therapies, reducing immune rejection and enhancing patient access.
04 June 2026
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