StemEdit OC-1 Protein
03-0020
Brand: StemEdit
StemEdit OC-1 Protein is a recombinant, AI-designed genome editing nuclease developed as a next-generation alternative to conventional Cas nucleases. It combines high editing efficiency with low off-target activity while enabling license-free genome engineering research, helping researchers simplify project planning and reduce intellectual property barriers.
Currency:
| Product name | Catalog number | Pack size | Price | Price (USD) | Price (GBP) | Price (EUR) |
|---|---|---|---|---|---|---|
| StemEdit OC-1 Protein | 03-0020 | 130 µg (10 µL) | (select above) | $ 600.00 | £ 565.00 | € 660.00 |
Note: prices shown do not include shipping and handling charges. To get a quote, make an inquiry.
Product Information
License-Free Genome Editing for Research
StemEdit OC-1 (OpenCRISPR-1™) Protein is an AI-designed gene editing protein developed as a license-free alternative to conventional Cas nucleases.
Why Choose StemEdit OC-1?
✔ License-Free for Research Use
No additional nuclease licensing required for research applications.*
✔ High Editing Efficiency
Robust genome editing performance across a wide range of cell types.
✔ Low Off-Target Activity
Designed for precise and reliable genome modification.
✔ AI-Designed Technology
Engineered using advanced AI-guided protein design for next-generation genome editing.
StemEdit OC-1 Protein was devised using large protein language models (LLMs) pre-trained on millions of naturally occurring CRISPR–Cas sequences to learn the underlying principles of functional genome editors.1 These models were then fine-tuned specifically on CRISPR–Cas data to guide generation toward proteins with the structural and functional characteristics of Cas9-like nucleases, creating novel gene editors far outside the range of sequences found in nature. OC-1 was identified from millions of sequences based on its strong editing activity, on-target efficiency comparable to traditional SpCas9, and reduced off-target effects in human cells, making it well-suited for genome engineering applications in stem cell and cell therapy research.
StemEdit OC-1 Protein is an open-source gene-editing tool that requires no license to use. Users remain responsible for ensuring compliance with applicable third-party intellectual property covering guide RNAs, delivery methods, and downstream applications.
Find out about the science behind the OC-1 protein in our recent blog post.
Applications
- Knock-in of large gene fragments (e.g., reporters, regulatory elements)
- Knock-in of biallelic mutations for disease models or functional studies
- Knock-out of single or multiple genes
StemEdit OC-1 Protein is intended for Research Use Only. For clinical therapeutic gene editing projects, please contact our (StemEdit) service team to learn more about our genome engineering capabilities.
See also:
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StemEdit Gene Edited iPSCs — Our hypoimmune iPSCs
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StemEdit Clinical Gene Editing Service — Our license-free editing services.
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Clinical Stem Cell Services — Clinical-grade iPSC solutions.
- StemRNA™ iPSCs — Research-grade iPSC collection.
Figure. StemEdit OC-1 Protein was assayed for gene editing activity using a test guide RNA and a target cell, and the data were analyzed using the ICE App (https://ice.editco.bio/#/). This assay showed that this batch of OC-1 achieved 80% indel formation, demonstrating robust gene editing activity.
Stemgent and the StemEdit brand name are trademarks of REPROCELL Inc., Japan. OpenCRISPR-1 is a trademark of Profluent Bio, Inc.