3D Neurite Outgrowth Model
By measuring neurite outgrowth you can assess the effects of your test articles on neurite formation or toxicity. Our translational neurite outgrowth model combines our award-winning Alvetex scaffold technology with iPSC-derived human neurons to produce a mature, neuronal network that develops dense synaptic connections.
Developed in partnership with the University of Durham, REPROCELL’s iPSC-derived StemRNA™ Neuro cells - available as healthy wild-type and Alzheimer Disease patient-derived (presenilin 2 mutation) - are used to assess pathological changes in vitro. This system is compatible with many physiological and pathological ECM coatings (laminin, CSPGs), known pathway inhibitors, and therapeutic lead compounds.
- Measure inhibition and recovery of neurite outgrowth
- Use iPSC-derived StemRNA™ Neuro cells derived from healthy or Alzheimer Disease donors
- Explore pathological changes in functional human cells in vitro
- Assess physiological and pathological ECM coatings, known pathway inhibitors, and test articles
Immunocytochemistry analysis showing neurites in our 3D outgrowth model.