3D Tissue Models and Microphysiological Systems Using Alvetex®
For more than 15 years REPROCELL’s CSO, Professor Stefan Przyborski, has harnessed our award-winning Alvetex 3D scaffold technology to test pharmaceutical compounds in skin, liver, and neuronal tissues. By combining the human relevance of our iPSC-derived cell lines with Alvetex technology, our team can develop custom microphysiological systems to meet your research needs.
Because human cells exist in three dimensions (3D) in vivo, culturing them in a two-dimensional (2D) format results in loss of form and function. Bio-engineered 3D tissue models have repeatedly demonstrated a more accurate response to drugs, chemicals, and cosmetics than their 2D counterparts because:
- They more closely mimic human tissue micro-anatomy
- They are more phenotypically accurate e.g. maintenance of CYP450 activity in 3D in comparison with 2D culture
- They allow you to interrogate the mechanisms of action of your compound with confidence
