SynFire® Induced Neurons

SynFire is a brand name for iPSC-derived Neurons

SynFire neurons from Neucyte Labs are pure and ready-to-use iPSC-derived glutamatergic or GABAergic induced neurons (iNs) and astroglia. This platform most closely resembles real human neurobiology observed in primary cultures, providing the ability to effectively study the function of human neurons in vitro.

Advantages of SynFire iNs

• Real Human Biology – These cells more closely resemble real human biology than alternatives such as common animal models or other iPSC-based systems.

• Rapid and Homogeneous Maturation – SynFire iNs develop mature synaptic network activity within 3-4 weeks. These iNs show synchronous bursting phenotypes similar to rodent primary cultures.

• Reliable, Robust, and Ready-to-Use Cultures – This differentiation approach results in a highly defined in vitro system with lot-to-lot consistency that provides reproducible results.

• Flexible Modular System – The user can control subtype seeding densities and ratios to customize cultures to specific projects. Custom kit configurations are available.

Applications of SynFire iNs

Applications of SynFire iNs include a range of neurobiological and functional research outputs, such as:

• In vitro neural disease modeling
• Neuronal cell-based assays
• Neural subtype-specific biochemistry
• Target ID and validation in biologically relevant tissue
• Neural cytotoxicity (apoptosis, mitochondrial activity, etc.)
• Cell Stress tests
• Neural network physiology assessment (MEA)
• Seizurogenic potential testing
• Neurite outgrowth and morphology evaluation
• Mechanism of Action prediction by gene expression profiling

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