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REPROCELL’s
Landing Pad Technology

What Is "Landing Pad" Technology?

“Landing Pad” technology creates a predefined genomic docking site that enables rapid and precise insertion of therapeutic genes into engineered cells. Instead of rebuilding the entire knock-in workflow for every new genetic payload, researchers can reuse the established landing pad to efficiently add or exchange genes, saving time and reducing associated lab costs.

Rather than relying on random genomic integration, REPROCELL installs a reusable Landing Pad into validated genomic safe harbour loci such as AAVS1 and CLYBL. These sites support stable gene expression while minimizing disruption to endogenous cellular functions.

The result is a modular, plug-and-play engineering system that simplifies and accelerates development of advanced cell therapies while supporting consistent and reproducible gene expression.

Landing Pad Technology

Benefits of Landing Pad Technology

✓ Reduced Timelines and Project Costs
Avoid rebuilding knock-in workflows from scratch for each new genetic payload, helping accelerate development and reduce associated lab costs.

✓ Precise Genomic Integration
Therapeutic payloads into validated safe harbor sites for controlled and reproducible expression.

✓ Stable Long-Term Expression
Avoid variability commonly associated with random integration methods.

✓ Plug-and-Play Flexibility
Rapidly exchange or add new genetic payloads without redesigning the entire engineering workflow.

✓ License-free
Reducing IP and commercialization barriers for research and therapeutic development

✓ Translationally Focused
Built to support research, preclinical, and future GMP-compatible workflows.

Designed for Advanced Cell Therapy Development

REPROCELL’s Landing Pad platform supports integration of:

  • CAR constructs for CAR-T and CAR-NK development

  • Immune-modulating proteins such as CD47

  • Reporter genes including mCherry/mNeonGreen and Luciferase

  • Safety switches 

  • Multiplex engineering strategies for hypoimmune cell therapies

By combining Landing Pad Technology with hypoimmune iPSC engineering as a service- StemEdit and off-the-shelf hypoimmune lines, REPROCELL enables development of scalable off-the-shelf allogeneic cell therapy platforms.

Example Applications

Application Use Case
CAR-T / CAR-NK Engineering Stable CAR insertion into safe harbour loci
Hypoimmune Cell Therapies Immune-evasive engineered iPSCs
Safety Switch Engineering Controlled elimination of therapeutic cells
Reporter Cell Lines Functional assays and tracking
Synthetic Biology Modular payload integration

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