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Alvetex Advanced Tissue Bioengineering System - hero

Alvetex® Advanced Tissue Bioengineering System

Alvetex® Advanced is REPROCELL’s next-generation 3D tissue platform, designed for scientists who need biologically relevant, reproducible models such as skin for testing pharmaceuticals, cosmetics, chemicals, and devices. Powered by our proven Alvetex® scaffold technology, it creates the most accurate engineered human tissue available on the market.

Overview

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Alvetex Advanced Tissue Bioengineering System - overview 1

Why Alvetex Advanced?

  • Biologically-Accurate Tissue Models
    Flexible scaffold design enables creation of advanced 3D human tissue, such as skin, that closely mimics native tissue.
  • Easy Topical Application
    Direct access to the epidermal/barrier surface allows simple testing of creams, chemicals, devices, or measurement probes.
  • Leak-Free Innovation
    A unique tissue seal between compartments minimises leakage and eliminates “edge effects” — especially useful for barrier assays.
  • Non-Invasive Functional Readouts
    Compatible with standard skin barrier and physiology measurements, including pH, TEWL, TEER, water loss, and dye penetration.
  • Seamless Lab Integration
    Inserts can be transferred between standard and custom plate formats without disrupting cultures.
  • Customisable Handles & Interfaces
    Interchangeable handles allow precise control of insert depth, medium volume, and air-liquid interface positioning.
  • Flexible Incubation Options
    Models can be maintained in single wells using commercial plates or REPROCELL’s custom deep-well formats.

AVP022__1

  • AVP022-6 — 6 inserts, 1 holder & lid
  • AVP022-12 — 12 inserts, 2 holders & lids
  • AVP022-24 — 24 inserts, 4 holders & lids
  • AVP022-48 — 48 inserts, 8 holders & lids
  • AVP022-60 — 60 inserts, 10 holders & lids
  • AVP022-96 — 96 inserts, 16 holders & lids

Alvetex Advanced 15 mm modular inserts enable long term 3D culture. Designed for greater flexibility needed for advanced tissue bioengineering, cells grown in Alvetex Advanced modular inserts can receive media nutrients from above and below the membrane.

The Alvetex membrane is housed within a specially designed insert providing a tight seal around its perimeter, enabling the construction of tight tissue models and barrier testing.

AVP022 drawing 2

Packs contain multiple units of 6× Alvetex Advanced 15 mm modular inserts inside a 6-well holder with lid. (The 6-well holder and lid can also be purchased separately as AVP031 (see below).) Alvetex Advanced 15 mm modular inserts contain Alvetex Scaffold membranes. Each unit is sterile blister packed.

AVP022 drawing 3 all

AVP022__3

The insert holder (also available separately as AVP031) can support 6 Alvetex Advanced modular inserts and is designed such that the culture medium beneath is separated from the upper side of the insert, reducing the risk of media contamination during interactions with the surface of the bioengineered model. The insert holder  fits into the single welled plates (AVP027, AVP028 or AVP029), deep 6 well plate (AVP026) and most common commercial 6 well plates.


Handles for Alvetex® Advanced modular inserts

Handles for Alvetex® Advanced modular inserts are for pairing with other items from the Advanced modular plasticware range. The different handle sizes (low, medium, high) enable users to choose the depth of the models during culture and therefore directly influence the volume of cell culture media required.

Low handles (AVP023)

AVP023__01

  • AVP023-12 — 12 low handles
  • AVP023-24 — 24 low handles
  • AVP023-48 — 48 low handles
  • AVP023-60 — 60 low handles
  • AVP023-96 — 96 low handles

Medium handles (AVP024)

AVP024__01

  • AVP024-12 — 12 medium handles
  • AVP024-24 — 24 medium handles
  • AVP024-48 — 48 medium handles
  • AVP024-60 — 60 medium handles
  • AVP024-96 — 96 medium handles

High handles (AVP025)

AVP025__1

  • AVP025-12 — 12 high handles
  • AVP025-24 — 24 high handles
  • AVP025-48 — 48 high handles
  • AVP025-60 — 60 high handles
  • AVP025-96 — 96 high handles

AVP023 AVP024 ADP025 drawing 1
Handles of different lengths allow the user to control the height of the Alvetex Advanced modular insert within the culture plate, providing greater control of media volumes and capability for growth and the air-liquid interface.

AVP023 drawing 1
  • AVP026-5 — 5 deep plates 6-well, with lid
  • AVP026-10 — 10 deep plates 6-well, with lid
  • AVP026-15 — 15 deep plates 6-well, with lid

AVP026__1

 

Designed for the Alvetex® Advanced 3D tissue bioengineering system but useful for a wide variety of cell culture applications, our highly versatile Advanced deep plates 6 well give the researcher more flexibility by reducing the required number of culture media changes. Supplied with lid.

AVP026 drawing 1

Advanced deep plates 6 well needs to be paired with 6-well holder for Alvetex® Advanced modular inserts (AVP030 or AVP031), or Alvetex® Advanced insert holders (AVP023, AVP024, and/or AVP025). 

The insert holder can support 6 Alvetex Advanced modular inserts (AVP022) and is designed such that the culture medium beneath is separated from the upper side of the insert, reducing the risk of media contamination during interactions with the surface of the bioengineered model. AVP031 fits into the single welled plates (AVP027, 028 or 029), deep 6 well plate (AVP026) and most common commercial 6 well plates.


Advanced Single Well Plates (50 ml / 75 ml / 125 ml)

Designed for the Alvetex® Advanced 3D tissue bioengineering system, our Advanced single well plates (AVP027 / AVP028 / AVP029) enable several 3D bioengineered tissue models to share the same culture media. (Supplied with lid.)

Advanced deep plates need to be paired with 6-well holder for Alvetex® Advanced modular inserts (AVP030 or AVP031). AVP031 also requires Alvetex® Advanced insert holders (AVP023, AVP024, and/or AVP025).

Advanced Single Well Plates 50 ml, With Lid (AVP027)

AVP027__1

  • AVP027-5 — 5 deep plates 50 ml, with lid
  • AVP027-10 — 10 deep plates 50 ml, with lid
  • AVP027-15 — 15 deep plates 50 ml, with lid

AVP027 drawing 1

Advanced Single Well Plates 75 ml, With Lid (AVP028)

AVP028__1

  • AVP028-5 — 5 deep plates 75 ml, with lid
  • AVP028-10 — 10 deep plates 75 ml, with lid
  • AVP028-15 — 15 deep plates 75 ml, with lid

AVP028 drawing 1

Advanced Single Well Plates 125 ml, With Lid (AVP029)

AVP029__1

  • AVP029-5 — 5 deep plates 125 ml, with lid
  • AVP029-10 — 10 deep plates 125 ml, with lid
  • AVP029-15 — 15 deep plates 125 ml, with lid

AVP029 drawing 1

  • AVP030-2 — 2 handle holders
  • AVP030-4 — 4 handle holders
  • AVP030-10 — 10 handle holders

Designed for use with Advanced deep well plates (AVP027, AVP028 or AVP029), paired with Alvetex® Advanced modular well insert handles (low AVP023, medium AVP024, or high AVP025). 

AVP030__1
AVP030 drawing 2
  • AVP031-1 — 1 × 6-well holders, with lid
  • AVP031-2 — 2 × 6-well holders, with lid
  • AVP031-10 — 10 × 6-well holders, with lid

Designed for 6 Alvetex Advanced modular inserts (without handles), for enabling researchers to easily move bioengineered tissue models between different format plates with minimal disruption. This holder also provides a layer of separation between the surface of the model and the media source below—useful during the topical application of test compounds/flora to skin models without contaminating the media. 

 

AVP031__1
AVP031 drawing 1