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REPROCELL Brand: Stemgent

Overview

The Stemgent brand is well known in the global stem cell research community. The brand has become associated with stem cell performance-qualified reagents and innovation after becoming the first company to launch a mRNA reprogramming kit for making iPSCs. Today, the organization is armed with broader capabilities and expertise, and has recently developed a third generation reprogramming technology (StemRNA 3rd Gen RNA Reprogramming) which is now available through iPSC reprogramming services. All of this, combined with complementary REPROCELL know-how from across the globe, uniquely positions the organization with a full-range of iPSC services including reprogramming, differentiation and expansion & characterization.

Stemgent’s customers include pharmaceutical and biotechnology companies, as well as top academic and government research institutions from all around the globe. Reprogramming technology and iPSC usage can also be made available for a variety of commercial applications with licenses available through REPROCELL Inc. (please inquire).

History

The Stemgent brand of REPROCELL has it origins in 2008 when the company was founded with headquarters established in Cambridge, MA, and a satellite office in San Diego, CA. The corporate business model was to commercialize research tools for induced pluripotent stem cell (iPSC) research, including reprogramming technologies and stem cell reagents. It was acquired by REPROCELL in 2014, and Stemgent resources have since relocated to the headquarters of REPROCELL USA, located in Beltsville, MD in August 2017. Stemgent’s reputation was built on cutting-edge mRNA-based iPSC reprogramming technology and a portfolio of stem cell–qualified reagents including small molecules (Stemolecule™) and protein factors (StemFactor™) to facilitate reprogramming and stem cell growth & maintenance.

Timeline

2016Stemgent merges operations with BioServe (Beltsville, MD) to become part of REPROCELL USA Inc.
2014Stemgent iPS cell business unit is acquired by REPROCELL company (Japan)
2010Stemgent held the first commercially available iPS training course at the National Institute of Health facility
2010Stemgent and Miltenyi Biotec announced partnership for co-development and worldwide sale of stem cell research products
2010Stemgent launches custom iPS cell reprogramming services
2009Stemgent is voted as one of the Top 25 up-and-coming biotechnology companies by a prominent global publishing organization
2008Stemgent is founded, offering the first set of research tools focused on cellular reprogramming

Stemgent Product Sub-Brands

StemRNA™StemRNA is a brand of Stemgent for our mRNA-based reprogramming technology and kits, and the cells derived from iPS Cells generated using this technology. StemRNA reprogramming technology offers vector-free, rapid, high-efficiency reprogramming of fibroblasts and blood and urine cells to generate clinically relevant iPS cells ready for differentiation.
StemAb™StemAB is a brand of Stemgent for our portfolio of antibodies targeted against stem cell-specific pluripotency markers. StemAB antibodies are validated for use a variety of applications including FACS and immunofluorescence microscopy staining. StemAB antibodies are useful for monitoring the quality of iPS cells and ES Cells after reprogramming or isolation.
StainAlive™StainAlive is a brand of Stemgent for a series of specially prepared StemAb antibody products that are non-toxic and sterile. This allows for their use in live cell cultures to ascertain surface marker expression. The StainAlive series of antibodies are all directed against stem cell pluripotency markers. Hence, use of these antibodies is helpful for determining the extent of reprogramming in a given experiment.
Stemfect™

Stemfect is a brand of Stemgent. The Stemfect RNA Transfection Kit is a proprietary mixture of lipid components is specifically designed for in vitro RNA transfection. This kit has been shown to deliver mRNA, siRNA and miRNA with greater than or equal to 90% transfection efficiency into a range of cell types with greater than 95% viability.

Stemfactor™Stemfactor is a brand of Stemgent for a series of growth factors, cytokines and other purified proteins that are reagents useful for stem cell reprogramming, maintenance or differentiation. Stemfactors are high quality reagents sourced from suppliers that have been validated by REPROCELL for products that have superior performance in stem cell applications.
Stemolecule™

Stemolecule is a brand of Stemgent for a series of small molecules that are reagents useful for stem cell reprogramming, maintenance or differentiation. Most Stemolecule such as Y27632 and CHIR99021 are enzyme inhibitor. Stemolecules are high quality reagents sourced from suppliers that have been validated by REPROCELL for products that have superior performance in stem cell applications.

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