StemEdit OC-1 Protein
03-0020
Brand: StemEdit
StemEdit OC-1 Protein is a recombinant, AI-designed gene editing protein engineered for efficient and precise genome modification. Designed as an alternative to conventional Cas nucleases, OC-1 protein provides high editing efficiency and low off-target activity to support genome engineering research.
Currency:
| Product name | Catalog number | Pack size | Price | Price (USD) | Price (GBP) | Price (EUR) |
|---|---|---|---|---|---|---|
| StemEdit OC-1 Protein | 03-0020 | 10 μg | (select above) | $ 600.00 | £ 565.00 | € 660.00 |
Note: prices shown do not include shipping and handling charges. To get a quote, make an inquiry.
Product Information
The first AI-designed Cas alternative protein.
StemEdit OC-1 (OpenCRISPR-1™) Protein is an AI-designed gene editing protein developed as an alternative to conventional Cas nucleases. It was devised using large protein language models (LLMs) pre-trained on millions of naturally occurring CRISPR–Cas sequences to learn the underlying principles of functional genome editors.1 These models were then fine-tuned specifically on CRISPR–Cas data to guide generation toward proteins with the structural and functional characteristics of Cas9-like nucleases, creating novel gene editors far outside the range of sequences found in nature. OC-1 was identified from millions of sequences based on its strong editing activity, on-target efficiency comparable to traditional SpCas9, and reduced off-target effects in human cells, making it well-suited for genome engineering applications in stem cell and cell therapy research.
Find out about the science behind the OC-1 protein in our recent blog post.
Applications
- Knock-in of large gene fragments (e.g., reporters, regulatory elements)
- Knock-in of biallelic mutations for disease models or functional studies
- Knock-out of single or multiple genes
StemEdit OC-1 Protein is intended for Research Use Only. For clinical therapeutic gene editing projects, please contact our (StemEdit) service team to learn more about our genome engineering capabilities.
Check out our ready-to-use Hypoimmune Cell Lines, made using StemEdit OC-1 Protein.
Figure. StemEdit OC-1 Protein was assayed for gene editing activity using a test guide RNA and a target cell, and the data were analyzed using the ICE App (https://ice.editco.bio/#/). This assay showed that this batch of OC-1 achieved 80% indel formation, demonstrating robust gene editing activity.
Stemgent and the StemEdit brand name are trademarks of REPROCELL Inc., Japan. OpenCRISPR-1 is a trademark of Profluent Bio, Inc.