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Human-Relevant Skin Research Starts with the Right Model

Whether you're developing new therapies, investigating skin biology or assessing biological responses, reliable answers start with a relevant model. REPROSKIN™ is a full-thickness human skin equivalent designed to provide physiologically relevant data while offering the flexibility required for modern skin research.

Talk to a REPROSKIN specialist

REPROSKIN in insert cutaway cartoon draft 4

Above: Alvetex® Advanced insert cut-away showing REPROSKIN™ full thickness human skin model.

Custom Built to Reflect Real Human Skin

REPROSKIN™ recreates key structural and functional features of native human skin, providing a versatile platform for skin research and therapeutic evaluation.

icon 1 - Enable advanced studies

Enable advanced studies

Perform tape stripping, imaging and other surface-access experiments.

icon 2 - Long-term culture capability

Long-term culture capability

Maintain tissue for extended studies 
and repeat experiments.

icon 3 - Robust barrier function

Robust barrier function

Assess barrier integrity with TEWL,
dye penetration and more.

icon 4 - Accessible skin surface

Accessible skin surface

Ideal for topical application, dosing and environmental exposure studies.

Meet REPROSKIN™

A Human-Relevant Model for Skin Research

REPROSKIN is a full-thickness human skin equivalent designed to replicate key structural and functional features of native skin. Combining epidermal and dermal compartments within a controlled in vitro system, the model provides a biologically relevant platform for investigating skin biology, evaluating therapeutics and assessing biological responses.

H&E staining demonstrating the full-thickness architecture of REPROSKIN, including a differentiated epidermis and fibroblast-populated dermal compartment.

Alvetex-Advanced_scene-4

REPROSKIN is constructed using REPROCELL's proprietary Alvetex® Advanced technology, which supports the formation of a robust three-dimensional dermal compartment. This unique platform promotes physiologically relevant tissue architecture while enabling the flexibility required for advanced skin research applications.

Alvetex Scaffold skin model

Above: Illustration of the REPROSKIN full-thickness skin model.

Generate Data with Greater Confidence

Traditional 2D systems often fail to capture the complexity of human skin. REPROSKIN provides:

  • ✓ Full-thickness skin architecture
  • ✓ Accessible surface for topical and environmental exposure studies
  • ✓ Long-term culture capability
  • ✓ Reproducible and controlled experimental conditions

REPROSKIN production workflow 4

Two Ways to Access REPROSKIN™

Purchase REPROSKIN™

For teams that want:

  • Immediate access to tissues
  • Internal assay development
  • Full experimental control
  • Scalable in-house testing
Product Name Product Code Pack size

REPROSKIN™ Full Thickness Human Skin Equivalent

Designed to provide a physiologically relevant in vitro model for preclinical dermatology research, toxicity testing and mechanistic studies.

 RSK001-FT-6
RSK001-FT-12		 1 plate
2 plates

REPROSKIN™ Maintenance Media Kit

Contains EpiLife™ Medium, with 60 μM calcium (500ml) and Qkine recombinant human KGF (FGF7) 25 µg, required for routine maintenance and culture of REPROSKIN tissues at the air-liquid interface. (Also required but not included: 100 mg/mL ascorbic acid; 1.64 mM CaCl2.)

 RSK-MEDIA-01 1 kit

Work with our Scientists

For teams that need:

  • Contract research
  • Custom models (aged, wounded or pigmented)
  • Endpoint analysis
  • Data interpretation

Explore REPROSKIN™ services

Ask us about REPROSKIN

Not sure which option is right for you?

Our skin specialists can help identify the most appropriate model, study design or service offering based on your research objectives.