Stemolecule™ Y27632
04-0012 / 04-0012-10 / 04-0012-02
Brand: Stemolecule™
Y27632 is an inhibitor of Rho-associated kinase (ROCK) which is widely used to enhance survival of dissociated PSCs. It is common to supplement cell culture medium with 10 µM of ROCK Inhibit or during cell passage or while establishment of spheroids during the first 24 hours.
- Y-27632
- (1R,4R)-4-((R)-1-aminoethyl)-N-(pyridine-4-yl)cyclohexanecarboxamide dihydrochloride
Currency:
| Product name | Catalog number | Pack size | Price | Price (USD) | Price (GBP) | Price (EUR) |
|---|---|---|---|---|---|---|
| Stemolecule™ Y27632 (2 mg) | 04-0012 | 2 mg | (select above) | $ 172.00 | £ 140.00 | € 164.00 |
| Stemolecule™ Y27632 (10 mg) | 04-0012-10 | 10 mg | (select above) | $ 675.00 | £ 552.00 | € 646.00 |
| Stemolecule™ Y27632 (2 mg solution in DMSO (10 mM)) | 04-0012-02 | 2 mg (10 mM) | (select above) | $ 191.00 | £ 155.00 | € 182.00 |
Note: prices shown do not include shipping and handling charges.
Product Information
Y27632 is a cell-permeable small molecule Rho-associated kinase (ROCK) inhibitor1. Y27632 has been found to prevent apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency2. This molecule has also been shown to enhance survival during the transplantation of ES cell-derived neural precursors3. Y27632 in combination with Pifithrin-u significantly improves cell recovery after cryopreservation4.
Stemolecule Y27632 is also available as a 10 mM DMSO Stock Solution in DMSO (2 mg in 624.4 μl) (Cat. No. 04-0012-02).
Y27632 is widely used in naive stem cell protocols5, such as the 5i/L/A/ protocol.
Stemgent and the Stemolecule brand name are trademarks of REPROCELL Inc., Japan.