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iMatrix-111 Hepatoblast-Like Epithelial Cell Culture Substrate

NP892-071 / NP892-072

Brand: iMatrix™ by Matrixome®

iMatrix-111 is a highly purified and refined product of human recombinant laminin-111 (E8 fragment) expressed by CHO-S cells. Laminin 111 supports the survival, proliferation, and differentiation of many different cell types in vitro. However, its distribution after birth is restricted to only a few tissues, such as the brain and kidney. 


Note: prices shown do not include shipping and handling charges.

Product code Pack size The Americas   UK, Europe, Middle East, Africa
(USD)   UK (GBP) Europe (EUR)

NP892-071
NP892-072

175 μg × 2 tubes
175 μg × 6 tubes

$ 684.00
$ 1,708.00

 

£ 674.47
£ 1,686.16

€ 787.78
€ 1,969.44

  USA store  
The Americas
Product code Pack size USD

NP892-071
NP892-072

175 μg × 2 tubes
175 μg × 6 tubes

$ 684.00
$ 1,708.00

USA store
UK, Europe, Middle East, Africa
Product code Pack size UK (GBP)

NP892-071
NP892-072

175 μg × 2 tubes
175 μg × 6 tubes

£ 674.47
£ 1,686.16

Europe (EUR)

NP892-071
NP892-072

175 μg × 2 tubes
175 μg × 6 tubes

€ 787.78
€ 1,969.44


imatrix-111

iMatrix-111's features make it an ideal matrix for some cell culture applications:

  • Xeno-free formulation / CHO-S cell bioproduction
  • Easy to use (liquid format)
  • E8-fragments retain integrin binding specificity and capacity, and display higher potency than natural Laminin-221

iMatrix-111 is a highly purified and refined product of human recombinant laminin-111 (E8 fragment) expressed by CHO-S cells. Laminin 111 supports the survival, proliferation, and differentiation of many different cell types in vitro. However, its distribution after birth is restricted to only a few tissues, such as the brain and kidney. Many of the cultivated cell types would not encounter this protein naturally in vivo and it is advisable to match your specific cell type to the laminin naturally expressed by this cell, improving the cell culture. During development, Riechert’s membrane supporting the extraembryonic trophoblasts express laminin 111. Reichert’s membrane is essential for epiblast differentiation, which is essential for the formation of the three embryonic germ layers by pluripotent cells in the inner cell mass.

In the adult, laminin α1 chain expression is relatively restricted and is only present in some epithelial basement membranes, and primarily found in tissues such as the eye, liver, and kidney, whereas hardly expressed at all in endothelial, adipose, nervous, or muscle tissues.

Specifications

Product Name: iMatrix-111 Cell Culture Substrate

Catalog Numbers:

  • NP892-071
  • NP892-072

Sizes:

  • NP892-071 — 2 × 175 µg
  • NP892-072 — 6 × 175 µg

Molecular Weight: 150 kDa

Purity: > 95 % pure

Formulation: Purified Laminin-111 E8 proteolytic fragment

Storage and Stability: Store at 4 °C and protect from light exposure. Stable for 2 years from manufacturing date.

Quality Control: Activity: Kd for integrin binding

Sterility: Sterile

Notice To Purchaser: REPROCELL is a licensed distributor of Matrixome cell culture substrates to the global market.

Recommended Usage: iMatrix-111 is suitable for use as a substrate for culture of various cell types.

Concentration: 500 µg/mL

Source: CHO-S cell expression

Manufacturer: Matrixome Corporation (Japan)

Documents

Safety Data Sheets:

Product Flyer: