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|Product Code||Pack Size||Price in
|Price in EMEA|
|04-0014||2 mg||USD $ 119.00||GBP £ 92.13||EUR € 104.57|
|04-0014-10||10 mg||USD $ 399.00||GBP £ 353.03||EUR € 400.69|
Prices do not include shipping and handling charges.
A83-01 is a selective inhibitor of the transforming growth factor-β (TGFβ) type I receptor ALK5, the Activin/Nodal receptor ALK4, and the nodal receptor ALK71. This molecule is more potent than SB431542 in its inhibition of ALK4, 5, and 7, and only weakly inhibits ALK1, 2, 3, and 6. A83-01 inhibits the TGFβ-induced epithelial-to-mesenchymal transition (EMT) via the inhibition of Smad2 phosphorylation2.
Product Name: Stemolecule A83-01
Catalog Number: 04-0014
Chemical Formula: C25H19N5S
Molecular Weight: 421.52
CAS Number: 909910-43-6
Purity: Greater than 98% by HPLC analysis
Formulation: Pale yellow solid
Solubility: A83-01 is soluble in DMSO at 50 mM.
Storage and Stability: Store powder at 4 °C protected from light. Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at −20 °C. The effect of storage of stock solutions should be verified for each application.
Quality Control: The purity of A83-01 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. No acute cytotoxicity was observed in mouse embryonic stem cells following a 6 hour exposure to 1 nM - 100 µM A83-01.
Stem Cell Reagents
3D Cell Culture
Zara Puckrin, BSc / 8 June 2021
Zara Puckrin, BSc / 31 May 2021
Lydia Costello, PhD / 25 May 2021
21 June 2021
24 May 2021
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