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‹ Product Catalog

Products for 3D Cell Culture

Three-dimensional (3D) cell culture has grown in interest for tissue engineering and drug discovery applications by providing a more physiologically relevant cellular structure. 3D culture allows cells to interact in all directions with their surrounding cellular and extracellular neighbours.

REPROCELL offers a variety of 3D cell culture technologies to support a range of experimental designs, from skin models to cancer invasion to in vivo implantation to embryoid body formation.

Alvetex 12-well insert

Alvetex® – by REPROCELL®

REPROCELLʼs Alvetex brings a new dimension to your research capabilities, delivering more in vivo-like results over two-dimensional monolayer cultures. Comprised of highly porous cross-linked polystyrene, Alvetex has been adapted to fit a variety of conventional cell-culture plasticware formats. We have extensive protocols and application notes covering a wide variety of cell types.

Alvetex provides:

  • Genuine 3D cell culture
  • Ideal geometry for 3D culture
  • Easy transfer from 2D culture
  • Stability for long-term studies
  • Requires no specialized equipment

❯ Alvetex 3D Cell Culture Systems

❯ Alvetex Advanced Tissue Bioengineering

Alvetex Scaffold microscopic structure (SEM)

Scanning electron micrograph (SEM) image of Alvetex Scaffold.

Alvetex Scaffold in 96 well plate format

Alvetex Scaffold in 96 well plate format.

Alvetex Advanced bioengineered full thickness human skin

Full-thickness human skin model grown on the  Alvetex Advanced tissue bioengineering system.

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Alvetex Advanced 15 mm modular inserts containing Alvetex Scaffold, in insert holder.

AteloCell® Atelocollagen – by Koken®

Collagen is an extracellular matrix found in the dermis, ligaments, bones, etc., and accounts for approximately 30% of the total protein in the human body. AteloCell atelocollagen, from Koken, Ltd., Is comprised of peptides formed by peptidase treatment of native collagen.

AteloCell atelocollagen forms a wide variety of physical forms, and it is bio-absorbable, making it ideal for combined in vitro – in vivo studies. AteloCell has been widely used for studies involving nerves, bone and connective tissue.

❯ AteloCell Atelocollagen

Atelocollagen Honeycomb Sponge

AteloCell Honeycomb Sponge

Atelocollagen membrane (transparent)

AteloCell membrane (transparent)

EZSPHERE™ – by Asahi Glass Corporation®

EZSPHERE™ microfabricated vessels, from Asahi Technical Glass Co., Ltd, are created by lasers to have multiple, regularly-spaced, precisely controlled microwells of 200-1400 µm diameter and 100-400 µm depth etched into the bottom of a traditionally-sized culture dish. The plates and microwells are coated with a proprietary polymer coating to minimize protein binding.

These plates are ideal for forming uniformly-sized microaggregates, such as Embryoid Bodies (EBs).

EZSPHERE dishes are formatted for 6-, 24-, and 96-well microplate, as well as a variety of culture dishes.

❯ EZSPHERE microwell dishes and plates

EZSPHERE microwells

EZSPHERE microwells

EZSPERE - EB formation

EB formaton on EZSPHERE