Purchase product: USA Store
|Product Code||Pack Size||Price in
|Price in EMEA|
|04-0036||2 mg||USD $ 99.00||GBP £ 80.51||EUR € 91.39|
|04-0036-50||50 mg||USD $ 900.00||GBP £ 696.76||EUR € 790.84|
Prices do not include shipping and handling charges.
Wnt Inhibitor IWP-4 was identified in a high throughput screen for antagonists of the Wnt / β-catenin pathway. Wnt Inhibitor IWP-4 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, there by blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin1.
New 50 mg size now available.
Product Name: Stemolecule Wnt Inhibitor IWP-4
Catalog Number: 04-0036
Size: 2 mg
Alternate Name(s): 2-(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
Chemical Formula: C23H20N4O3S3
Molecular Weight: 496.62
CAS Number: 686772-17-8
Purity: Greater than 96 % by HPLC analysis
Formulation: White solid
Solubility: This molecule is reported to be soluble in DMSO at 1.2 mM.
Reconstitution: For a 1.2 mM concentrated stock solution of Wnt Inhibitor IWP-4, reconstitute the compound by adding 3.36 mL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For use in cell culture, keep the total DMSO concentration less than 0.1%.
Storage and Stability: Store powder at 4 °C protected from light. Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at − 20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.
Quality Control: The purity of Wnt Inhibitor IWP-4 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of Wnt Inhibitor IWP-4 was tested on mouse embryonic stem cells.
Stem Cell Reagents
3D Cell Culture
Zara Puckrin, BSc / 8 June 2021
Zara Puckrin, BSc / 31 May 2021
Lydia Costello, PhD / 25 May 2021
21 June 2021
24 May 2021
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