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Stemolecule™ Wnt Inhibitor IWP-4

04-0036 / 04-0036-50

Brand: Stemolecule

Wnt Inhbitor IWP-4 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity.

CAS Number: 686772-17-8
Alternate Name(s):
  • 2-(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide


Product name Product code Pack size Price (USD) Price (GBP) Price (EUR)
Stemolecule™ Wnt Inhibitor IWP-4 04-0036 2 mg $ 120.00 £ 99.00 € 115.00
Stemolecule™ Wnt Inhibitor IWP-4 04-0036-50 50 mg $ 1,092.00 £ 886.00 € 1,046.00

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Product Information

Wnt Inhibitor IWP-4 was identified in a high throughput screen for antagonists of the Wnt / β-catenin pathway. Wnt Inhibitor IWP-4 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, there by blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin1.

New 50 mg size now available.


Stemgent and the Stemolecule brand name are trademarks of REPROCELL Inc., Japan.

Product Name: Stemolecule Wnt Inhibitor IWP-4

Catalog Number: 04-0036

Size: 2 mg

Alternate Name(s): 2-(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide

Chemical Formula: C23H20N4O3S3

Molecular Weight: 496.62

CAS Number: 686772-17-8

Purity: Greater than 96 % by HPLC analysis

Formulation: White solid

Solubility: This molecule is reported to be soluble in DMSO at 1.2 mM.

Reconstitution: For a 1.2 mM concentrated stock solution of Wnt Inhibitor IWP-4, reconstitute the compound by adding 3.36 mL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For use in cell culture, keep the total DMSO concentration less than 0.1%.

Storage and Stability: Store powder at 4 °C protected from light. Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at − 20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.

Quality Control: The purity of Wnt Inhibitor IWP-4 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of Wnt Inhibitor IWP-4 was tested on mouse embryonic stem cells.

Specification Sheets:

Safety Data Sheets:

  1. Chen, B., Dodge, M.E., Tang, W., Lu, J., Ma, Z., Fan, C.W., Wei, S., Hao, W., Kilgore, J., Williams, N.S., Roth, M.G., Amatruda, J.F., Chen, C., and Lum, L. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 5: 100-107 (2009).

Additional Publications