Through an extensive array of ex vivo human tissue assays, 3D models and stem cells, REPROCELL is able to provide invaluable human safety data for your compound early in the development cycle. REPROCELL is the only GLP laboratory undertaking tests using human fresh functional tissues.
The benefits of undertaking safety testing in human tissues are many. When carried out in conjunction with the ICH S7A core battery, our data can provide an unparalleled indication of clinical safety and even reduce the number of animals required for in vivo experimentation. More importantly though, our data can help reduce the number of late stage failures as ‘go’ or ‘no go’ decisions can be made with confidence based on human responses.
In addition to the positive effect on cost and time to clinic, human safety data adds significant value for investors and potential partners.
Routine safety assays conducted by REPROCELL include:
Condition | Tissue | Technique |
Blood pressure | Human subcutaneous resistance arteries | Vessel diameter – wire myography |
Myocardial infarction or angina | Human coronary artery | Vessel diameter – wire myography |
Diarrhoea or constipation | Human colon Human gall bladder |
Fluid transport – Ussing chambers Gut motility – Organ baths Gall bladder contractility – Organ baths |
Cardiac contractility | Human ventricular trabeculae | Electrical field stimulation – Organ baths |
Human heart
Force of contraction measured in organ baths
Comparisons between human and animal data are often vital, as safety in animals does not always mean safety in humans. REPROCELL can conduct comparative pharmacology studies across the main preclinical species, generating data on your compounds in humans and animals.
The graph below shows the differences in responsiveness of bronchi from various species to a range of bronchoconstrictors. No species accurately predicts human responses.
Predictive Drug Discovery Assay Services
Online Resources
22-25 March 2021 / Virtual Meeting
We are participating in Europe’s largest Springtime Biotech Partnering Digital Event. Please schedule a virtual meeting with us!
REPROCELL
Products
Services
© 2021 REPROCELL Inc. All rights reserved.
REPROCELL Inc. 日本語 MetLife Shin-yokohama 381, Bldg. 9F, 3-8-11 Shin-yokohama, Kohoku-ku, Yokohama, Kanagawa 222-0033, Japan
REPROCELL USA Inc. 9000 Virginia Manor Road, Suite 207, Beltsville, 20705, USA
REPROCELL Europe Ltd. Thomson Pavilion, Todd Campus, West of Scotland Science Park, Acre Road, Glasgow, G20 0XA, United Kingdom
Bioserve Biotechnologies (India) PVT Ltd. Unit: D4-D7, 1st Floor, Industrial Estate, Moula Ali, Medchal-Malkajgiri Dist., Hyderabad-500040, Telangana, India