iMatrix-511 is a highly purified and refined laminin-511 E8 fragments, produced in CHO cells.
iMatrix-511 features make it an ideal matrix for pluripotent stem cell culture:
Laminin is localized to the basement membrane, and plays a key role in cell adhesion and proliferation. Laminin-511 (α5, β1 laminin) binds to integrin α6β1 to promote cell signaling. Laminin-511 provides an ideal matrix for the proliferation of a wide variety of cell types including stem and iPS cells.
iMatrix-511 is functionally equivalent to iMatrix-511 SILK (Cat. No. NP892-021). The only difference is the expression system used for bioproduction. The iMatrix-511 SILK product is produced in recombinant silkworm cocoon, while iMatrix-511 is produced in CHO-S cells. Both are E8 fragments that have been purified using the same processes.
iMatrix-SILK Stem Cell Culture Substrate
Purified Laminin-511 E8 proteolytic fragment
Storage and Stability
Store at 4 °C and protect from light exposure. Stable for 2 years from manufacturing date.
Integrin binding Kd < 10 nM
Notice To Purchaser
REPROCELL is a licensed distributor of Matrixome cell culture substrates to the global market.
iMatrix-511 SILK is suitable for use as a substrate for culture of various cell types, including ES/iPS cells.
Matrixome Corporation (Japan)