Stemolecule™ SB431542
04-0010 / 04-0010-10 / 04-0010-05
Brand: Stemolecule™
SB421542 is an inhibitor of the transforming growth factor-beta 1 (TGF-?1) activin receptor-like kinases (ALKs).
CAS Number: 301836-41-9 (anhydrous)
Alternate Name(s):
- 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
Currency:
| Product name | Catalog number | Pack size | Price | Price (USD) | Price (GBP) | Price (EUR) |
|---|---|---|---|---|---|---|
| Stemolecule™ SB431542 (5 mg) | 04-0010 | 5 mg | (select above) | $ 135.00 | £ 110.00 | € 129.00 |
| Stemolecule™ SB431542 (10 mg) | 04-0010-10 | 10 mg | (select above) | $ 229.00 | £ 188.00 | € 220.00 |
| Stemolecule™ SB431542 (5 mg in solution (10 mM)) | 04-0010-05 | 5 mg in solution (10 mM) | (select above) | $ 151.00 | £ 123.00 | € 144.00 |
Note: prices shown do not include shipping and handling charges.
Product Information
SB431542 is an inhibitor of the transforming growth factor-β 1 (TGFβ1) activin receptor-like kinases (ALKs). It is a selective and potent inhibitor of ALK-4, -5 and -7. SB431542 inhibits endogenous activin and TGFβ signaling without affecting more divergent BMP signaling utilizing ALK-1, -2, -3, and -61,2. SB431542 stimulates proliferation, differentiation, and sheet formation of endothelial cells derived from embryonic stem cells3.
Stemolecule SB431542 is also available as a 10 mM DMSO Stock Solution in DMSO (5 mg in 1.3 ml) (Cat. No. 04-0010-05).
Stemgent and the Stemolecule brand name are trademarks of REPROCELL Inc., Japan.
Product Name: Stemolecule SB431542
Catalog Number: 04-0010-base
Size:
- 10 mg (Cat. No. 04-0010-10)
- 5 mg (Cat. No. 04-0010)
- 5 mg at 10 mM in DMSO (5 mg in 1.3 ml) (04-0010-05)
Alternate Name(s): 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
Chemical Formula: C22H16N4O3
Molecular Weight: 384.4
CAS Number: 301836-41-9 (anhydrous)
Purity: Greater than 97 % by HPLC analysis
Formulation: White solid
Solubility: Reconstitute in DMSO to the desired concentration. For reconstitution instructions please reference product specifications sheet.
Storage and Stability: Store powder at 4 °C protected from light. Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at −20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.
Quality Control: The purity of SB431542 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of SB431542 was tested on mouse embryonic stem cells.
Specification Sheets:
Safety Data Sheets:
- Matsuyama, S., Iwadate, M., Kondo, M., Saitoh, M., Hanyu, A., Shimizu, K., Aburatani, H., Mishima, H.K., Imamura, T., Miyazono, K., Miyazawa, K. SB-431542 and Gleevec inhibit transforming growth factor-β-induced proliferation of human osteosarcoma cells. Cancer Res 63: 7791-7798 (2003).
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- Watabe, T., Nishihara, A., Mishima, K., Yamashita, J., Shimizu, K., Miyazawa, K., Nishikawa, S., and Miyazono, K. TGFβ receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. J Cell Biol 163: 1303-1311 (2003).
Additional Publications
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