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Stemolecule™ SB431542

04-0010 / 04-0010-05 / 04-0010-10

Brand: Stemgent™

SB421542 is an inhibitor of the transforming growth factor-beta 1 (TGF-β1) activin receptor-like kinases (ALKs).


Note: prices shown do not include shipping and handling charges.

Product code Pack size The Americas   UK, Europe, Middle East, Africa
(USD)   UK (GBP) Europe (EUR)

04-0010
04-0010-05
04-0010-10

5 mg
5 mg in solution (10 mM)
10 mg

$ 104.00
$ 115.00
$ 177.00

 

£ 80.48
£ 89.34
£ 136.57

€ 91.35
€ 101.40
€ 155.01

  USA store  
The Americas
Product code Pack size USD

04-0010
04-0010-05
04-0010-10

5 mg
5 mg in solution (10 mM)
10 mg

$ 104.00
$ 115.00
$ 177.00

USA store
UK, Europe, Middle East, Africa
Product code Pack size UK (GBP)

04-0010
04-0010-05
04-0010-10

5 mg
5 mg in solution (10 mM)
10 mg

£ 80.48
£ 89.34
£ 136.57

Europe (EUR)

04-0010
04-0010-05
04-0010-10

5 mg
5 mg in solution (10 mM)
10 mg

€ 91.35
€ 101.40
€ 155.01


Stemolecule-04-0010

SB431542 is an inhibitor of the transforming growth factor-β 1 (TGFβ1) activin receptor-like kinases (ALKs). It is a selective and potent inhibitor of ALK-4, -5 and -7. SB431542 inhibits endogenous activin and TGFβ signaling without affecting more divergent BMP signaling utilizing ALK-1, -2, -3, and -61,2. SB431542 stimulates proliferation, differentiation, and sheet formation of endothelial cells derived from embryonic stem cells3.

Specifications

Product Name: Stemolecule SB431542

Catalog Number: 04-0010-base

Size:

  • 10 mg (Cat. No. 04-0010-10)
  • 5 mg (Cat. No. 04-0010)
  • 5 mg at 10 mM in DMSO (04-0010-05)

Alternate Name(s): 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide

Chemical Formula: C22H16N4O3

Molecular Weight: 384.4

CAS Number: 301836-41-9 (anhydrous)

Purity: Greater than 98 % by HPLC analysis

Formulation: White solid

Solubility: Reconstitute in DMSO to the desired concentration. For reconstitution instructions please reference product specifications sheet.

Storage and Stability: Store powder at 4 °C protected from light. Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at −20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.

Quality Control: The purity of SB431542 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of SB431542 was tested on mouse embryonic stem cells.

Documents

Specification Sheets:

Safety Data Sheets:

References

  1. Matsuyama, S., Iwadate, M., Kondo, M., Saitoh, M., Hanyu, A., Shimizu, K., Aburatani, H., Mishima, H.K., Imamura, T., Miyazono, K., Miyazawa, K. SB-431542 and Gleevec inhibit transforming growth factor-β-induced proliferation of human osteosarcoma cells. Cancer Res 63: 7791-7798 (2003).
  2. Laping, N.J., Grygielko, E., Mathur, A., Butter, S., Bomberger, J., Tweed, C., Martin, W., Fornwald, J., Lehr, R., Harling, J., Gaster, L., Callahan, J.F., and Olson, B.A. Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542. Mol Pharmacol 62: 58-64 (2002).
  3. Inman, G.J., Nicolás, F.J., Callahan, J.F., Harling, J.D., Gaster, L.M., Reith, A.D., Laping, N.J., and Hill, C.S. SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 62: 65-74 (2002).
  4. Watabe, T., Nishihara, A., Mishima, K., Yamashita, J., Shimizu, K., Miyazawa, K., Nishikawa, S., and Miyazono, K. TGFβ receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. J Cell Biol 163: 1303-1311 (2003).

Additional Publications