Stemolecule™ PD0325901

04-0006 / 04-0006-10 / 04-0006-02

Brand: Stemolecule™

PD03225901 inhibits mitogen-activated protein kinase (MAPK/ERK kinase or MEK) and demonstrates potential antineoplastic activity.

CAS Number: 391210-10-9

Alternate Name(s):

N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide

Currency:

Product name	Catalog number	Pack size	Price	Price (USD)	Price (GBP)	Price (EUR)
Stemolecule™ PD0325901 (2 mg)	04-0006	2 mg	(select above)	$ 276.00	£ 227.00	€ 266.00
Stemolecule™ PD0325901 (10 mg)	04-0006-10	10 mg	(select above)	$ 1081.00	£ 885.00	€ 1034.00
Stemolecule™ PD0325901 (2 mg in solution (10 mM))	04-0006-02	2 mg in solution (10 mM)	(select above)	$ 324.00	£ 266.00	€ 311.00

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Note: prices shown do not include shipping and handling charges.

Product Information

PD0325901 is a small molecule targeting mitogen-activated protein kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation^1,2. Along with the ALK5 inhibitor SB431542, PD0325901 has also been shown to increase the efficiency of reprogramming human primary fibroblasts into induced pluripotent stem (iPS) cells³.

Stemolecule PD0325901 is also available as a 10 mM DMSO Stock Solution in DMSO (2 mg in 414.8 μl) (Cat. No. 04-0006-02).

Stemgent and the Stemolecule brand name are trademarks of REPROCELL Inc., Japan.

Product Name: Stemolecule PD0325901

Catalog Number: 04-0006

Size

2 mg (Cat. No. 04-0006)
10 mg (Cat. No. 04-0006-10)
2 mg solution in 10 mM DMSO (2 mg in 414.8 μl)(Cat. No. 04-0006-02)

Alternate Name(s): N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide

Chemical Formula: C₁₆H₁₄F₃IN₂O₄

Molecular Weight: 482.19

CAS Number: 391210-10-9

Purity: Greater than 95 % by HPLC analysis

Formulation: Pale purple solid

Solubility: Reconstitute in DMSO to the desired concentration. For reconstitution instructions please reference product specifications sheet.

Storage and Stability: Store powder at 4 °C protected from light. Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at −20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.

Quality Control: The purity of PD0325901 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. No acute cytotoxicity was observed in mouse embryonic stem cells following a 6 hour exposure to 1 nM — 100µm of PD0325901.

Handling: Before opening, briefly centrifuge the vial to ensure full recovery of sample. Aliquotting the stock solution is recommended to avoid repetitive freeze-thaw cycles. For cell culture, the media should be prewarmed prior to adding the reconstituted compound. Note: for most cells, the maximum tolerance to DMSO is less than 0.5%.