Stemolecule™ ec23

SRP002 / SRP002-2

Brand: Stemgent™

Purchase product: USA Store

Product Code Pack Size Price in
The Americas
Price in EMEA
SRP002 5 mg USD $ 68.00 GBP £ 38.00 EUR € 45.50
SRP002-2 2 × 5 mg
USD $ 136.00 GBP £ 76.00 EUR € 91.00

Prices do not include shipping and handling charges.


ec23 is a pan-RAR receptor agonist that is stable and maintains the same biological activity as ATRA (all trans retinoic acid). ATRA is well known for its ability to regulate cell differentiation. However, retinoids such as ATRA are excellent chromophores and efficiently absorb light and isomerise. This is not a desirable property for cell culture reagents where consistency and reliability of a molecule is important for robust, reproducible results.

REPROCELL routinely test the stability of the our synthetic compounds in line with their development as stable alternatives to known biological molecules. The structural stability of ec23 and ATRA were examined by NMR during prolonged exposure to light. ATRA shows significant isomerisation and degradation whereas ec23 remains completely intact.

Robust induction of neurogenesis by ec23

The synthetic retinoid, ec23 is a potent inducer of pluripotent stem cell differentiation. Human pluripotent stem cells exposed to either 10 uM ec23 or ATRA form populations of terminally differentiated neurons. Immunocytochemical staining for neurofilament-200 was performed on differentiated cultures and the number of positive cells quantified. Results show that ec23 is a more potent inducer of neurogenesis than ATRA. In direct comparison to ATRA, synthetic retinoid ec23 induces larger numbers of neural cells with less variability and with the added advantage of compound stability.

Synthetic retinoid ec23 is also a potent inducer of neurogenesis by adult neuroprogenitor cells. Rat adult hippocampal progenitor cells (AHPCs) exposed to either 1 uM ec23 or ATRA differentiate into neural cell types. Differentiation induced by exposure to ec23 was consistent and reproducible.

Human EC cells exposed to either ec23 or ATRA form populations of terminally differentiated neurons after 21 days. Immunocytochemical staining for neurofilament-200 was performed on differentiated cultures.


Product Name: Stemolecule ec23

Catalog Number: SRP002


  • 2 × 5 mg (SRP002-2)
  • 5 mg (SRP002)

Alternate Name(s): 4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylethynyl) benzoic acid

Chemical Formula: C23H24O2

Molecular Weight: 332 g/mol

CAS Number: 104561-41-3

Purity: Greater than 99% by HPLC analysis

Formulation: Off-white solid

Solubility: Reconstitute in DMSO to the desired concentration. For reconstitution instructions please reference product specifications sheet.

Storage and Stability: Store powder at ≤20 °C. Following reconstitution, store in aliquots at −20 °C. Stock solutions are stable for 6 months when stored as directed.

Quality Control: The purity of ec23 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry.


  1. Christie VB; Barnard JH; Batsanov AS; Bridgens CE; Cartmell EB; Collings JC; Maltman DJ; Redfern CPF; Marder TB; Przyborski S; Whiting A. Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Org Biomol Chem 6: 3497 (2008).

Additional Publications